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- Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial + (Nabiximol via oral spray (self-applied by patient, one spray 2.7 mg THC and 2.5 mg CBD) Week 1: dose finding; week 2-5: stable dose Maximal number of sprays: 6-10 (medium dose))