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Inglis et al. (2020): Effects of High-Dose Vitamin D Supplementation on Phase Angle and Physical Function in Patients with Prostate Cancer on ADT + (Placebo vitamin D weekly, over 24 weeks + all participants: daily multivitamin containing the RDA for vitamin D: 600 IU/day + 210 mg/day calcium and calcium supplements (800 mg/day))
Stratton et al. (2010): Oral Selenium Supplementation Has No Effect on Prostate- Specific Antigen Velocity in Men Undergoing Active Surveillance for Localized Prostate Cancer + (Placebo; Follow-up duration (mean (SD); median): 36.3 (20.7); 38.4 years)
Rao et al. (2014): The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study + (Povidone-iodine solution (diluted 1:100; 1ml Betadine, 100ml water), Mouthwash, 10ml twice daily Duration: 6 weeks)
Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy + (Propionyl-L-Carnitin (PLC) 2g daily + Acetyl-L-Carnitin (ALC) 2g daily + 100mg Sildenafil if required Duration: 4 month)
Stephenson et al. (2017): Partner-delivered reflexology: Effects on cancer pain and anxiety. + (Reading aloud by a partner/family member/friend (reading of own choice) Duration: 1x 30 minutes; And usual care)
Stephenson et al. (2000): The Effects of Foot Reflexology on Anxiety and Pain in Patients With Breast and Lung Cancer. + (Received reflexology first and then served as their own control. (1x 30 min), at least 48 h break, passive control/no intervention (1x 30 min))
Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment + (Reflex therapy by study partners who were trained 2x in a 30min. protocol for reflex therapy by reflexologists (duration: 30 min., study weeks 1-4: minimum requirement 1x/week, real average 1.1/week; SW 5-11: no requirements, average 0.6/week))
Stephenson et al. (2017): Partner-delivered reflexology: Effects on cancer pain and anxiety. + (Reflexotherapy of the Ingram method by a partner/family member who has received 15-30 minutes of instruction from a certified reflex therapist Duration: 1x 30 minutes; And usual care)
Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (Same form and frequency as in Vit. B arm (oral, 3 lactose capsules daily))
Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (Sativex® (Nabiximol, THC 27 mg/mL, CBD 25 mg/mL) via oral spray (self-applied by patient) * week 1: dose finding; week 2-5: stable dose, max. 10 sprays * first week mean number of sprays: 3.7, stabilized over 4 weeks (6.3 sprays per day))
Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (Sativex® (nabiximol, THC 27 mg/mL, CBD 25 … Sativex® (nabiximol, THC 27 mg/mL, CBD 25 mg/mL) via oral spray (self-applied by patient);week 1: dose finding; week 2-5: stable dose, max. 10 sprays* Part A: first week average number of sprays: 3.6; second week: 6.4* Part B: average daily number: 6.5k: 6.4 * Part B: average daily number: 6.5)
Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial + (Selenium tablet (Webber Naturals, Coquitlam, BC, Canada, 200 mcg) twice daily, from the starting day of HDC to 14 days after transplantation)
Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck + (Selenomethionine 3600 µg/m²(in 800 µg tablets) 2x daily 7 days before chemotherapy, during chemotherapy 1x daily, and daily for 3 weeks after chemotherapy)
Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy + (Sildenafil 100mg if required + Placebo Duration: 4 month)
Asfour et al. (2006): Effect of high-dose sodium selenite therapy on polymorphonuclear leukocyte apoptosis in non-Hodgkin's lymphoma patients + (Sodium selenite was administered on days 3–7 of the chemotherapy)
Khodabakhshi et al. (2019): Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study + (Standard diet (55% carbohydrates, 15% protein, and 30% fat))
Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial + (Stimulation of the reflex points 20 min. of the right foot and 10 min. of the left foot, 2x/week, 5 weeks in total), + chemoradiantherapy)
Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer + (Supplied by Genzyme as 2.5 μg soft gel cap … Supplied by Genzyme as 2.5 μg soft gel capsules,10 μg (i.e., four capsules of 2.5 μg) of doxercalciferol orally each day of the chemotherapy cycles before breakfast and at the same time,Duration: for 1-12 cycles of chemotherapy (each cycle: 28 days), median duration: 6 cyclescycle: 28 days), median duration: 6 cycles)
Hodgson et al. (2012): Reflexology versus Swedish Massage to Reduce Physiologic Stress and Pain and Improve Mood in Nursing Home Residents with Cancer: A Pilot Trial. + (Swedish Massage protocol was prespeciﬁed a … Swedish Massage protocol was prespeciﬁed and involved a combination of 10 minutes of light stroking and light pressure using the whole hand toplantar and dorsal surfaces and all tissue from the toes to the knee of each leg (20 minutes total). The Reﬂexology Intervention was based on the original Ingram method and useda combination of ﬁnger pivot and thumb walking techniquesto the base of the foot and the toes that correspond withreﬂex points. The sole, instep, and lateral aspects of the footwere stimulated 5 times, each foot for a total of 10 minutesper foot (20 minutes total). of 10 minutesper foot (20 minutes total).)
Hodgson et al. (2012): Reflexology versus Swedish Massage to Reduce Physiologic Stress and Pain and Improve Mood in Nursing Home Residents with Cancer: A Pilot Trial. + (Swedish Massage protocol was prespeciﬁed a … Swedish Massage protocol was prespeciﬁed and involved a combination of 10 minutes of light stroking and light pressure using the whole hand toplantar and dorsal surfaces and all tissue from the toes to the knee of each leg (20 minutes total). The Reﬂexology Intervention was based on the original Ingram method and useda combination of ﬁnger pivot and thumb walking techniquesto the base of the foot and the toes that correspond withreﬂex points. The sole, instep, and lateral aspects of the footwere stimulated 5 times, each foot for a total of 10 minutesper foot (20 minutes total). of 10 minutesper foot (20 minutes total).)
Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (THC extract via oral spray (2.7 mg), dosage variable; Week 1: dose finding Week 2: stable dose, maximum of 8 sprays every 3 hours and 48 sprays in 24 hours: dose was determined by patients themselves)
Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (THC:CBD via oral spray (self-applied by patient, one dose 2.7mg THC and 2.5mg CBD) Week 1: dose finding Week 2: stable dose, maximum of 8 sprays every 3 hours and 48 sprays in 24 hours: dose was determined by patients themselves)
Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms + (The aloe vera solution consisted of 94.5% … The aloe vera solution consisted of 94.5% aloe juice, 5.0% pear juice concentrate, 0.4% lemon-lime flavor, and 0.1% citric acid.Patients were instructed to take a 20ml swish and swallow 4x daily, beginning on the first day and continuingthroughout the RT course.+ all patients were instructed to alleviate oral discomfort by rinsing daily with a baking soda mouth rinse, and swishing and swallowing Benadryl and nystatin combination mouthwashes and viscous lidocaine, as needed+ all patients: radiation dose 50-70 Gy at 1.8-2 Gy per dayadiation dose 50-70 Gy at 1.8-2 Gy per day)
Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms + (The aloe vera solution consisted of 94.5% … The aloe vera solution consisted of 94.5% water, 5.0% pear juice concentrate, 0.4% lemon-lime flavor, and 0.1% citric acid.Patients were instructed to take a 20ml swish and swallow 4x daily, beginning on the first day and continuingthroughout the RT course.+ all patients were instructed to alleviate oral discomfort by rinsing daily with a baking soda mouth rinse, and swishing and swallowing Benadryl and nystatin combination mouthwashes and viscous lidocaine, as needed+ all patients: radiation dose 50-70 Gy at 1.8-2 Gy per dayadiation dose 50-70 Gy at 1.8-2 Gy per day)
Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer. + (The foot reflexology was initiated during the evening on postoperative day 2 while patients are on PCA and between 1 and 3 hours after a dose of pain medication, day 3 after surgery and day 4 after surgery, duration: 20 min each))
Kessels et al. (2017): Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma A Randomized Clinical Trial + (The ointment was applied twice daily for six weeks by patients at home + all tumors were excised after eight weeks)
Kessels et al. (2017): Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma A Randomized Clinical Trial + (The ointment was applied twice daily for six weeks by patients at home + all tumors were excised after eight weeks)

Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study + (Three capsule containing soybean oil per day)
Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (Three capsule containing soybean oil per day)
Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (Three capsule containing soybean oil per day)
Lin et al. (2010): Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: subgroup analysis of a double-blind, randomized study + (Three capsule containing soybean oil per day)

Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial + (Three capsules of 10,000 IU Vitamin D3 weekly + all patients: 1200 mg of calcium plus 600 IU of vitamin D daily (‘‘standard supplementation’’) and Letrozole 2.5 mg PO daily)
Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial + (Three capsules of placebo weekly + all patients: 1200 mg of calcium plus 600 IU of vitamin D daily (‘‘standard supplementation’’) and Letrozole 2.5 mg PO daily)
Ertekin et al. (2004): Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study + (Three times daily at 8-hour intervals, cap … Three times daily at 8-hour intervals, capsules containing 50 mg zinc (Zinco 220 capsule),Duration was from first day of radiotherapy, during radiotherapy and for 6 weeks after treatment (including weekends and other times when interruption of radiotherapy was necessary)nterruption of radiotherapy was necessary))
Ertekin et al. (2004): Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study + (Three times daily at 8-hour intervals, emp … Three times daily at 8-hour intervals, empty capsules bought from the same medicine firm to be identical to the zinc sulfate capsules,Duration was from first day of radiotherapy, during radiotherapy and for 6 weeks after treatment (including weekends and other times when interruption of radiotherapy was necessary)nterruption of radiotherapy was necessary))
Paur et al. (2017): Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA + (Tomato products with 30 mg lycopene daily … Tomato products with 30 mg lycopene daily + 1 cup of green and black tea + 330ml pomegranate and grape juice + 200mg soy isoflavones + 200µg 1-selenemethionine + 3.13g n-3 fatty acids daily from 3 weeks before radiotherapy/surgery until radiotherapy/surgery for median (range)=22 (20-24) dayssurgery for median (range)=22 (20-24) days)
Paur et al. (2017): Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA + (Tomato products with 30 mg lycopene daily from 3 weeks before radiotherapy/surgery until radiotherapy/surgery for median (range)=21.5 (12-24) days)
Mansourian et al. (2015): The effect of "curcuma Longa" topical gel on radiation -induced oral mucositis in patients with head and neck cancer + (Topical turmeric gel (0.5%); Coat entire mouth with gel 3 times a day Start: day 0 radiotherapy Duration: entire radiotherapy (21 days))
Akiba et al. (2018): Vitamin D Supplementation and Survival of Patients with Non–small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial + (Two capsule form and identical in appearance and taste, containing sesame oil, gelatin derived from swine, and glycerin, for 12 months)
Akiba et al. (2018): Vitamin D Supplementation and Survival of Patients with Non–small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial + (Two capsules of vitamin D3 (total 1,200 IU/day), for 12 months)
Sontakke et al. (2003): Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study + (Two capsules, each containing 500 mg of gin- ger powder, orally, 2 ml of normal saline IV, 20 min prior to chemotherapy. Two capsules of ginger were repeated after 6 h of cancer chemotherapy.)
Keshavarzi et al. (2019): The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer + (Vaginal suppositories containing 1 mg of vitamin E plus 2 g of the base substance, every day before bedtime)
Keshavarzi et al. (2019): The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer + (Vaginal suppositories containing 2 g of the base substance plus 1000 IU of vitamin D (0.025 mg), every day before bedtime)
Keshavarzi et al. (2019): The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer + (Vaginal suppositories containing only 2 g of the base substance, every day before bedtime)
Minchom et al. (2014): An unblinded, randomised phase II study of platinum-based chemotherapy with vitamin B12 and folic acid supplementation in the treatment of lung cancer with plasma homocysteine blood levels as a biomarker of (...) + (Vit.B12: intramuscular, 1mg, before treatment and every 9 weeks until 3 weeks after last dose of chemotherapy Folic acid: oral, 400μg daily, start at least day seven days prior to chemotherapy, duration up to 3 weeks after chemotherapy)
Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial + (Vitamin D3 supplementation, 2000 IU/d, after surgery until the end of the trial)
Frankling et al. (2021): ‘Palliative-D’ - Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial + (Vitamin D3 oil drops (color and taste matched) 4000 IU/day, for 12 weeks)
Mansouri et al. (2016): The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial + (Washing mouthes with 5ml of aloe vera mouthwash (Saline, Cholorhexidine, and Nystatine) for 2 minutes 3 times a day and avoid eating and drinking for 30 minutes after that for 2 weeks.)
Mansouri et al. (2016): The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial + (Washing mouthes with 5ml of standard mouthwash (Saline, Cholorhexidine, and Nystatine) for 2 minutes 3 times a day and avoid eating and drinking for 30 minutes after that for 2 weeks.)
Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (Week 1: dose finding; week 2-5: stable dose, max. 10 sprays * Part A: first week average number of sprays: 3.6, second week: 6.4 * Part B: average daily number: 6.3)
Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer + (Worn for 5 days at a time from the day of the chemotherapy, inhaled deeply at least 3 times a day for 3 periods of 2 minutes each Start: Day 1 of chemotherapy)
Lyckholm et al. (2012): A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders + (Zinc dose was 220 mg orally twice daily (equivalent of 50 mg elemental zinc twice daily))
Ribeiro et al. (2017): Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer + (Zinc sulfate (154mg/capsule), which corresponded to 35mg of elemental zinc, a capsule after breakfast and dinner, which amounted to 70mg of elemental zinc per day)
Najafizade et al. (2013): Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: A randomized placebo-controlled trial + (Zinc sulfate capsules: 50 mg, three times a day, after meals, Duration of intervention: started with beginning of radiotherapy and continued one month after completion of irradiation)