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List of results

• Sanaati et al. (2016): Effect of Ginger and Chamomile on Nausea and Vomiting Caused by Chemotherapy in Iranian Women with Breast Cancer  + (Not separated by arm: - general weakness + discontinuation of chemotherapy (n=7) - further participation refused (n=6) - non-completion of questionnaires (n=6) - death (n=1))
• Toma et al. (2003): β-carotene supplementation in patients radically treated for stage I-II head and neck cancer: Results of a randomized trial  + (Not separated by arm: 3/4 (no further information obtained after randomization), 1/4 (randomized twice))
• Toma et al. (2003): β-carotene supplementation in patients radically treated for stage I-II head and neck cancer: Results of a randomized trial  + (Not separated by arm: 3/4 (no further information obtained after randomization), 1/4 (randomized twice))
• Fahimi et al. (2011): Evaluating the Effect of Zingiber Officinalis on Nausea and Vomiting in Patients Receiving Cisplatin Based Regimens  + (Not seperated by arm, overall: due to lack of compliance, n=1 due to pruritus and gastrointestinal complaints)
• Fahimi et al. (2011): Evaluating the Effect of Zingiber Officinalis on Nausea and Vomiting in Patients Receiving Cisplatin Based Regimens  + (Not seperated by arm, overall: due to lack of compliance, n=1 due to pruritus and gastrointestinal complaints)
• Pace et al. (2003): Neuroprotective Effect of Vitamin E Supplementation in Patient Treated With Cisplatin Chemotherapy  + (Not seperated by arm: interrupted treatment after two or three cycles because of disease progression n=18)
• Puataweepong et. al (2009): The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: a double-blind placebo-controlled study  + (One patient in the placebo arm discontinued the test solution due to unfavorable taste and was reported as a non-compliance.)
• Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck  + (Patient complained of "bad taste" and withdrew from the trial)
• Salehi et al. (2015): Effect of Vitamin E on Oxaliplatin-induced Peripheral neuropathy Prevention: A Randomized Controlled Trial  + (Patient decision n=1 Other medical problem n=1)
• Salehi et al. (2015): Effect of Vitamin E on Oxaliplatin-induced Peripheral neuropathy Prevention: A Randomized Controlled Trial  + (Patient decision n=2 Other medical problems n=1)
• Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study  + (Patient refusal and/or toxicity (41%, respectively); patient death (26%, respectively))
• Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study  + (Patient refusal and/or toxicity (45%, respectively); patient death (22%, respectively))
• Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study  + (Patient refusal and/or toxicity (58%, respectively); patient death (15%, respectively))
• Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial  + (Patient was non-adherent)
• Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients  + (Patient-initiated n=1, Ineligibility n=1, … Patient-initiated n=1, Ineligibility n=1, Non-compliance n=1</br></br>Overall reasons for n=5: </br>* patient-reported hot flashes (1/5)</br></br>* undisclosed personal reasons (1/5)</br></br>* ineligibility due to concurrent participation in another RT intervention trial (1/5)</br></br>* and noncompliance with study procedures (2/5) noncompliance with study procedures (2/5))
• Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients  + (Patient-initiated n=1, Non-compliance n=1 … Patient-initiated n=1, Non-compliance n=1</br></br>Overall reasons for n=5:</br></br>* patient-reported hot flashes (1/5)</br></br>* undisclosed personal reasons (1/5)</br></br>* ineligibility due to concurrent participation in another RT intervention trial (1/5)</br></br>* and noncompliance with study procedures (2/5) noncompliance with study procedures (2/5))
• Sangthawan et al. (2015): Effects of zinc sulfate supplementation on cell-mediated immune response in head and neck cancer patients treated with radiation therapy  + (Personal reasons)
• Rao et al. (2014): The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study  + (Personal reasons)
• Gujral et al. (2001): Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers  + (Personal reasons (n=1))
• Gujral et al. (2001): Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers  + (Personal reasons (n=1); died after the end of radiation (n=2))
• Henning et al. (2015): Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy  + (Personal reasons (n=3); surgery cancellation (n=1))
• Henning et al. (2015): Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy  + (Personal reasons (n=3); surgery cancelled (n=2); caffeine reactions (n=2))
• Cruciani et al. (2009): L-Carnitine Supplementation in Patients with Advanced Cancer and Carnitine Deficiency: A Double-Blind, Placebo-Controlled Study  + (Phase 1: n=1 death, n=2 deteriorations, n=2 with low fatigue Phase 2: no reasons given)
• Cruciani et al. (2009): L-Carnitine Supplementation in Patients with Advanced Cancer and Carnitine Deficiency: A Double-Blind, Placebo-Controlled Study  + (Phase 1: n=2 death, n=3 deteriorations, n=1 diarrhea, n=1 missed follow-up Phase 2: no reasons given)
• Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer.  + (Postoperative complications)

• Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy  + (Protocol violation n=2, Insufficient therapeutic effect n=2)

• Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy  + (Protocol violations)
• Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy  + (Protocol violations n=4, Insufficient therapeutic effect n=1)
• Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…)  + (Reason (n): Withdrawn consent (17) Serious adverse event (4) Other exclusion criterion (1) Death (4) Loss to follow-up (1) Other protocol violation (2))
• Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…)  + (Reason (n): Withdrawn consent (20) Serious adverse event (3) Other exclusion criterion (1) Death (8) Loss to follow-up (3))
• Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…)  + (Reason (n): Withdrawn consent (8) Serious adverse event (4) Other exclusion criterion (2) Death (1))
• Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial  + (Reasons not seperated by arm: 11x decease … Reasons not seperated by arm: </br>11x deceased, 9x other illness, 8x nausea, 5x excessive demands, 2x diarrhea, 7x other reasons, 2x Omega-3-FA intake, 1x uncooperative behavior when taking carnitine on the part of the patient</br></br>Drop-out rates and reasons: No difference between arms.s and reasons: No difference between arms.)
• Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial  + (Reasons not seperated by arm: 11x decease … Reasons not seperated by arm: </br>11x deceased, 9x other illness, 8x nausea, 5x excessive demands, 2x diarrhea, 7x other reasons, 2x Omega-3-FA intake, 1x uncooperative behavior when taking carnitine on the part of the patient</br></br>Drop-out rates and reasons: No difference between arms.s and reasons: No difference between arms.)
• Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer  + (Reasons: * delayed chemotherapy > 2 weeks: n = 3 * time problem: n = 1 * decline further study participation: n = 3)
• Salihah et al. (2016): The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting  + (Reasons: * delayed chemotherapy > 2 weeks: n = 3 * time problem: n = 1 * decline further study participation: n = 3)
• Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer  + (Reasons: * delayed chemotherapy > 2 weeks: n = 3 * very mild dizziness: n = 1 * decline further study participation: n = 4)
• Salihah et al. (2016): The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting  + (Reasons: * delayed chemotherapy > 2 weeks: n = 3 * very mild dizziness: n = 1 * decline further study participation: n = 4)
• Pace et al. (2010): Vitamin E neuroprotection for cisplatin neuropathy  + (Received less than 300mg cumulative dose)
• Pace et al. (2010): Vitamin E neuroprotection for cisplatin neuropathy  + (Received less than 300mg cumulative dose)
• Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial  + (Reduced thrombocyte values)
• Sangthawan et al. (2015): Effects of zinc sulfate supplementation on cell-mediated immune response in head and neck cancer patients treated with radiation therapy  + (Refused the radiation therapy)
• Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial  + (Refused to swallow capsules n = 1 Epileptic seizure grade 4, discontinued therapy n = 1)
• Pace et al. (2003): Neuroprotective Effect of Vitamin E Supplementation in Patient Treated With Cisplatin Chemotherapy  + (Reported n=2 suspended Vitamin E supplementation after 1 month, Not seperated by arm: interrupted treatment after two or three cycles because of disease progression n=18)
• Moslemi et al. (2014): Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial  + (Sever mucositis and interruption of treatment)
• Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial  + (Showed distant metastases on posttherapy scans)
• Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial  + (Showed distant metastases on posttherapy scans)
• Kasseroller et al. (2003): Efficacy and tolerability of proteolytic enzymes as an anti-inflammatory agent in lymphoedema after axillary dissection due to mammary cancer  + (Side effects)
• Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies  + (Side effects (n = 29, 14.6%), consent withdrawn (n = 8, 4%), death (n = 25, 68%))
• Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies  + (Side effects (n = 38, 19%); consent withdrawn (n = 19, 9.5%); death (n = 20, 10%))
• Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial  + (Side effects (n=20); consent withdrawn (n=4); progression of the disease (n=7))
• Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain  + (Side effects (n=35); consent withdrawn (n = 13); death (n=27))