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List of results

Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis + (NI)
Ghoreishi et al. (2007): Effect of vitamin E on chemotherapy-induced mucositis and neutropenia in leukemic patients undergoing bone marrow transplantation + (NI)
Büntzel et al. (2010): Selenium Substitution During Radiotherapy of Solid Tumours - Laboratory Data from Two Observation Studies in Gynaecological and Head and Neck Cancer Patients + (NI)
Arslan et al. (2015): Oral Intake of Ginger for Chemotherapy-Induced Nausea and Vomiting Among Women With Breast Cancer + (NI)
Antunac et al. (2018): Vitamin D Supplementation and Survival in Metastatic Colorectal Cancer + (NI)
Wrbka et al. (1987): Unterstützung der Chemotherapie inoperabler Karzinome durch proteolytische Fermente + (NI)
Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy + (Neuropathy caused by other antineoplastic … Neuropathy caused by other antineoplastic treatment except paclitaxel, cisplatin or vinblastine; pre-existing diabetes mellitus and/or neuropathy caused by vitamin deficiency, infection, trauma, poisoning, oppression, ischemia, metabolic disorders; genetic neuropathy and/or peripheral sensory nerve dysfunction due to central nervous system lesions; use of other drug therapy for neuropathy in the last 30 days (such as nerve growth factor, amifostine reduced glutathione, vitamin E or B, glucocorticoids, ethosuximide, carbamazepine, gabapentin, sodium thiosulfate, glutamic acid, lamotrigine, α-fatty acid, lithium salt, lithium salt or magnesium salt); participation in other clinical trials in the past 30 days; out of control clinical problems (such as serious mental, nerve, cardiovascular and/or respiratory system disease); pregnant or lactating women; and poor compliance.During the trial, patients were withdrawn if serious adverse events occurred, and/or the patient became pregnant.urred, and/or the patient became pregnant.)
Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer + (No prior or concurrent treatment for prost … No prior or concurrent treatment for prostate cancer; patients with a PSA doubling time <3 months; use of lycopene, fish oil or any other dietary or nutritional supplement within 4 weeks of study entry; use of Finasteride, Dutasteride, Saw Palmetto or any other herbal/nutritional preparation indicated to affect hormone levels within 4 weeks of study entry; use of NSAIDs, COX-2 inhibitors and/or aspirin for more than 7 days over the 1 month prior to study; history of allergic reactions attributed to tomatoes, fish, soybean or olive oil, gelatin capsules, or compounds of similar chemical or biologic composition to lycopene (carotenoids) or fish oil; uncontrolled intercurrent illness including, but not limited to, ongoing infection, congestive heart failure, unstable angina pectoris, cardiac arrhythmia or psychiatric condition that would limit compliance with study requirementsould limit compliance with study requirements)
Dardano et al. (2012): The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with Iodine-131 + (Not treated with external radiotherapy, no other illness except thyroid carcinoma)
Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study + (Ongoing use of tube feedings or parenteral … Ongoing use of tube feedings or parenteral nutrition; edema or ascites; treatment with adrenal corticosteroids (except for short-term dexamethasone during the time of chemotherapy), androgens, progestational agents, or other appetite stimulants within the previous month; brain metastases; insulin-requiring diabetes; pregnancy or lactation or unwillingness to use oral contraceptives; anticipated alcohol or barbiturate use during the study period; poorly controlled hypertension or congestive heart failure; history of thromboembolic disease; mechanical obstruction of the alimentary tract, malabsorption, or intractable vomitingct, malabsorption, or intractable vomiting)
Najafizade et al. (2013): Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: A randomized placebo-controlled trial + (Oral candidiasis or other oral lesions (e.g., stomatitis, necrosis, and ulcers), cranial nerve injuries, and metabolic/endocrine disorders that may have effects on taste perception)
Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial + (Palliative indications for pelvic irradiation; existence of a colostomy; known intolerance to proteolytic enzyme preparations or to contents of the study medication; participation in other clinical studies within the last 30 days)
Margalit et al. (2012): Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study + (Participants who had undergone prostatectomy prior to radiation therapy or who had metastatic disease at the time of radiation therapy)
Panahi et al. (2012): Effect of Ginger on Acute and Delayed Chemotherapy-Induced Nausea and Vomiting: A Pilot, Randomized, Open-Label Clinical Trial + (Participation in another study with different drugs; history of bone marrow or stem cell transplantation; presence of respiratory, cardiovascular, liver, renal, metabolic, or gastrointestinal diseases; and history of motion sickness)
Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment + (Patient exclusion criteria were 1) diagnos … Patient exclusion criteria were 1) diagnosis of major mental illness in the medical record and verified by the recruiter, 2) residing in a nursing home, 3) bedridden, 4) currently receiving reg- ular reflexology, or 5) diagnoses of symptoms of deep vein thrombosis or painful foot neuropathy.Friend/family caregiver: Exclusion criterion was unwilling to perform a return demonstration of the protocol according to training procedures.protocol according to training procedures.)
Howells et al. (2011): Phase I randomised double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases - safety, pharmacokinetics and pharmacodynamics + (Patient were asked to refrain from large quantities of resveratrol-containing foods and drinks such as peanuts, grapes, mulberries and alcohol within 48 h of scheduled PK collection days, and the day of surgical resection.)
Minchom et al. (2014): An unblinded, randomised phase II study of platinum-based chemotherapy with vitamin B12 and folic acid supplementation in the treatment of lung cancer with plasma homocysteine blood levels as a biomarker of (...) + (Patients having an active infection, inability or unwillingness to take vitamin supplementation, had taken any vitamins within the past 28 days or receiving concomitant radical chemotherapy and radiotherapy or antiepileptic treatment)
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (Patients on coumadin or heparin for therapeutic anticoagulation, patients with a bleeding disorder, patients who hadn't had platelet count >100,000/μl before the baseline cycle)
Newling et al. (1995): Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group + (Patients receiving chronic medication with salicylate derivatives, oestrogens, sulphonamides, isoniazid and steroids)
Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial + (Patients receiving long-term methadone the … Patients receiving long-term methadone therapy for pain; major psychiatric or cardiovascular disorder; epilepsy; significant renal or hepatic impairment; pregnant, lactating or not using adequate contraception; patients, who had received or who were due to receive therapies expected to change the pain (such as radiotherapy, or chemotherapy or hormonal therapy); marijuana use, cannabinoid-based medications or rimonabant within 30 days of study entry, and unwilling to abstain for the duration of the studyg to abstain for the duration of the study)
Upadhyaya et al. (2017): Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differential thyroid cancer: A randomized-controlled trial + (Patients treated previously for any other … Patients treated previously for any other malignancies by chemotherapy and/or radio-therapy, other head and neck cancers, patients with xerostomia because of any other reasons, other systemic disorders, patients with any deleterious habits, and patients on medications such as anticholinergics, anti-histaminics, drugs causing xerostomia, and other known radioprotective agents, and patients who received 131I other than 100 mCi doseswho received 131I other than 100 mCi doses)
Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study + (Patients using other gingers or the other … Patients using other gingers or the other antiemetic medication such as NK1 receptor antagonist or long-acting 5HT3 receptor antagonists to current study treatment; patients with gut obstruction or brain or bowel metastasis, patients using anticoagulant medication, and patients with allergy to gingeration, and patients with allergy to ginger)
Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial + (Patients were excluded if they had a Karnofsky performance status under 70%)
Stephenson et al. (2017): Partner-delivered reflexology: Effects on cancer pain and anxiety. + (Patients were excluded if they had had sur … Patients were excluded if they had had surgery in the previous six weeks or had open skin wounds on the feet, foot tumors or foot metastases, radiation to the feet, radiation to the site of pain, or more than 50% loss of feeling because of peripheral neuropathy. Patients with symptoms of deep vein thrombosis required a medical consultation prior to study participation or prior to continuation in the study if symptoms developed during the study.dy if symptoms developed during the study.)
Yekta et al. (2012): Ginger as a miracle against chemotherapy-induced vomiting + (Patients were excluded if they were receiv … Patients were excluded if they were receiving multiple-day chemotherapy; receiving concurrent radiotherapy with high risk of causing emesis (ie, total body, hemi body, upper abdomen, and craniospinal radiation); taking therapeutic doses of warfarin, aspirin, or heparin; had a history of bleeding disorder(s) like severe thrombocytopenia; had an allergy to ginger or had taken it in the last week; had gastrointestinal disorders and cancers; and had other emesis-inducing diseases, such as hypertension, liver, and renal failure.Patients who forgot to take capsules ≥ 3 consecutive times; used other antiemetic drugs or therapeutic methods except the routine antiemetic; had severe gastrointestinal problems during the study; and refusal to continue participating in trial.efusal to continue participating in trial.)

Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms + (Patients who are unable to complete the study questionnaires.)

Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck + (Patients who underwent definitive surgery … Patients who underwent definitive surgery (anything beyond excisional biopsy), those with Stage IVc disease (nonregional metastatic disease), those with malignancy within the previous five years, prior radiotherapy, HIV or hepatitis C positivity, platinum hypersensitivity, inability to tolerate oral medications (in absence of feeding tube), symptomatic peripheral neuropathy, planned use of amifostine, and significant comorbidityof amifostine, and significant comorbidity)
Marx et al. (2017): The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial + (Patients who were scheduled to receive rad … Patients who were scheduled to receive radiotherapy during the study period, were pregnant or lactating, concurrently used other ginger-containing supplements or ingested large quantities of ginger, had a history of adverse reactions to ginger, and/or thrombocytopenia.ctions to ginger, and/or thrombocytopenia.)
Azizi et al. (2015): Efficacy of Topical and Systemic Vitamin E in Preventing Chemotherapy-induced Oral Mucositis + (Patients who were supposed to receive head and neck radiotherapy as part of their treatment, patients who were taking anticoagulant therapy, as some studies have shown that vitamin E may increase the bleeding tendency.)
Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients + (Patients who: had bilateral breast cancer; … Patients who: had bilateral breast cancer; previous radiation to the chest or breast area; diagnosis of inflammatory breast cancer; breast reconstruction and/or expanders prior to RT; were taking anti-coagulant therapy (warfarin, coumadin or heparin) or antiepidermal growth factor receptor (EGFR) therapy or were receiving partial breast irradiationswere receiving partial breast irradiations)
Villani et al. (2016): Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial + (Patients with Karnofsky Performance Status >2, previous exposure to neurotoxic therapies, and/or risk factors for neuropathy onset (diabetes mellitus, chronic alcoholism))
Zalat et al. (2020): Evaluation of the cardioprotective effects of l-carnitine and silymarin in cancer patients receiving anthracycline-containing chemotherapy + (Patients with a history of heart failure, … Patients with a history of heart failure, arrhythmia, history of cardiac catheterizations or, history of angina, uncontrolled hypertension and uncontrolled diabetes, patients with impaired liver function tests, previous anthracycline-containing regimens and any cardiotoxic chemotherapy regimens, previous history of chest wall irradiation. Brain metastasis, pregnant patients, and patients who refused informed consent, patients who could not be sampled serially, or had bypass surgery, which precluded sampling throughout their hospital stayed sampling throughout their hospital stay)
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study + (Patients with a history of hypothyroidism, … Patients with a history of hypothyroidism, depression, or any other psychiatric disorder, anemia, prior antineoplastic treatment, or the inability to understand and sign an informed consent form.Patients who could be harmed by the stimulating properties of guarana, such as those with a history of insomnia, angina, or any cardiovascular disease, uncontrolled hypertension, or neurologic disorders.led hypertension, or neurologic disorders.)
Da Costa et al. (2009): Effectiveness of Guarana (Paullinia cupana) for Postradiation Fatigue and Depression Results of a Pilot Double-Blind Randomized Study + (Patients with a previous history of radiat … Patients with a previous history of radiation therapy, anemia, or clinical depression.Patients who were unable to grant informed consent or those who had medical contraindindications for the use of guarana (because of its psychostimulant effect) such as uncontrolled hypertension)effect) such as uncontrolled hypertension))
Vinzenz et al. (1992): Die Therapie der radiogenen Mukositis mit Enzymen + (Patients with an existing pregnancy; younger than 18 years or older than 80 years; patients with a known intolerance to the enzyme preparation)
Stephenson et al. (2000): The Effects of Foot Reflexology on Anxiety and Pain in Patients With Breast and Lung Cancer. + (Patients with cancer who reported no anxie … Patients with cancer who reported no anxiety on the VAS were excluded. Patients who had surgery within the past six weeks, open skin wounds on their feet, a foot tumor or foot metastasis, or radiation treatment to the feet also were excluded. Patients who received radiation to the site of pain were excluded. Patients with dementia or peripheral neuropathy also were excluded to ensure their responses were accurate. Patients who had recent surgery were excluded to differentiate chronic cancer- related pain from acute surgical paincer- related pain from acute surgical pain)
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (Patients with chronic diseases that could … Patients with chronic diseases that could induce fatigue, such as chronic renal failure, fibromyalgia, chronic anemia, and untreated hypothyroidism or with problems in the oral mucosa unrelated to the cancer. Patients with untreated depression and anxiety.nts with untreated depression and anxiety.)
Mondal et al. (2014): Comparative study among glutamine, acetyl-L-carnitine, vitamin-E and methylcobalamine for treatment of paclitaxel-induced peripheral neuropathy + (Patients with co‑morbidities like diabetes … Patients with co‑morbidities like diabetes, autoimmune diseases which include lupus, rheumatoid arthritis, kidney disease, liver disease and thyroid (hypothyroidism, tested pre‑enrollment by thyroid‑stimulating hormone, T4, T3) and with infections like hepatitis C and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV)/AIDS (all patients would undergo laboratory confirmation for shingles, hepatitis B, C and HIV/AIDS (at any Voluntary Confidential Counselling and Testing Centre, India) prior to inclusion in study), spinal cord injuries, peripheral vascular disorders known to be associated with peripheral neuropathy; uncontrolled diabetes or compromised cardiac function or any other major organ dysfunctions, other than cancer, which would require curtailment of full doses of paclitaxel at 175 mg/m2, 3 weekly regimensat 175 mg/m2, 3 weekly regimens)
Jeon et al. (2016): Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial + (Patients with history of allergy to systemic opioids, substance use disorder, coagulopathy, chronic opioid use, sleep apnea, and analgesic use within 24 h)
Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy + (Patients with history of ginger hypersensitivity, pregnancy or breast-feeding, and previous chemotherapy; patients with access to aprepitant or fosaprepitant; patients with poor blood values (e.g. AST, ALT, creatinine))
Sontakke et al. (2003): Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study + (Patients with maligancies of GIT, nausea and vomiting due to reasons other than chemotherapy, hypertension and renal or liver insufficiency)
Muecke et al. (2010): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology + (Patients with metastatic disease, diarrhea before radiotherapy, radiochemotherapy, or supplementation of selenium before radiotherapy, as well as patients who had undergone previous pelvic radiotherapy)
Sanaati et al. (2016): Effect of Ginger and Chamomile on Nausea and Vomiting Caused by Chemotherapy in Iranian Women with Breast Cancer + (Patients with multiple-day chemotherapy; r … Patients with multiple-day chemotherapy; receiving concurrent radiotherapy with high risk of causing emesis (i.e., total body, hemi body, upper abdomen, and craniospinal radiation); taking therapeutic doses of warfarin, aspirin, or heparin; had a history of bleeding disorder(s) like severe thrombocytopenia; had an allergy to ginger or chamomile or had taken it in the last week; had gastrointestinal disorders and cancers; and had other emesis-inducing diseases, such as hypertension, liver, and renal failure. Further exclusion of patients who met the following criteria: forgotten to take capsules ≥3 consecutive times; used other antiemetic drugs or therapeutic methods except the routine antiemetic; had severe gastrointestinal problems during the study; and refusal to continue participating in trial.efusal to continue participating in trial.)
Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer + (Patients with other malignancies, being allergic to ginger, perfumes or cosmetics or patients undergoing concurrent radiotherapy)
Emami et al. (2014): Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of green tea in preventing acute gastrointestinal complications due to radiotherapy + (Patients with past history of irradiation; diarrhea before the beginning of pelvic irradiation, taking another drug for treatment of diarrhea during the study, unwilling to participate in the study at any time)
Mayne et al. (2001): Randomized Trial of Supplemental beta-Carotene to Prevent Second Head and Neck Cancer + (Patients with prior upper aerodigestive tract cancers within the past 5 years, or with synchronous cancers of the esophagus or lung)
Van Zandwijk et al. (2000): EUROSCAN, a Randomized Trial of Vitamin A and N-Acetylcysteine in Patients With Head and Neck Cancer or Lung Cancer + (Patients with recurrent disease, synchronous multiple tumors, previous malignant disease, abnormal liver or renal function, hypertriglyceridemia, hypercholesterolemia, diabetes mellitus, hypertension, and recent or active peptic ulcer)
Khodabakhshi et al. (2019): Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study + (Patients with significant cardiac, renal or neurologic comorbidities, or an active state of malnutrition, diabetes, pregnancy, and Karnofsky index less than 70)
Bossi et al. (2017): A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high-dose cisplatin + (Patients with symptomatic brain metastases … Patients with symptomatic brain metastases; - scheduled to receive or having received, in the past 4 weeks, radiotherapy to upper abdomen or craniospinal region; - emesis or significant nausea within 24h before the first HEC cycle; - coagulation disorders or current therapy with oral anticoagulants; - planned surgery during the study period or within 2 weeks after its conclusion; - prior seizures; - cannabinoids or current/past drug or alcohol abuse; - use of other investigational drug(s) within 30 days before study entry or during the study; - any relevant condition potentially interfering with study evaluation; - known hypersensitivity to ginger or any components of the product.o ginger or any components of the product.)
Fallahi et al. (2013): Does vitamin E protect salivary glands from I-131 radiation damage in patients with thyroid cancer? + (Patients with xerostomia, previous salivar … Patients with xerostomia, previous salivary gland dysfunction, salivary stone or tumor, those who had undergone head and neck radiotherapy previously, who had known rheumatological diseases such as Sjögren’s disease, who had been administered 131I earlier, who had known liver disease, had taken drugs influencing salivary gland function, such as antihistaminic agents, beta-blockers, atropine, benzodiazepines, tricyclic antidepressants, and antipsychotic drugs in the past 2 weekspressants, and antipsychotic drugs in the past 2 weeks)
Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial + (People who had other types of cancer, whos … People who had other types of cancer, whose cancer recurred before the treatment, who had mental and psychiatric diseases, and who had contraindications for foot massage (such as disseminated edema, a pacemaker, a history of myocardial infarction, uncontrolled hypertension, active gout, deep vein thrombosis history, gallbladder or kidney stones, acute infection, fever, or a fracture or wound on the feet)fever, or a fracture or wound on the feet))