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List of results

Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study + (Pregnancy or lactation, nausea or vomiting … Pregnancy or lactation, nausea or vomiting prior to chemotherapy administration, presence of conditions that may cause nausea or vomiting (e.g., brain metastasis, bowel obstruction, hepatitis, or recent abdominal or pelvic irradiation within 1 week), bleeding diathesis, allergy to ginger, or concomitant treatment with other chemotherapy.omitant treatment with other chemotherapy.)
Ota et al. (2014): The effect of pyridoxine for prevention of hand-foot-syndrome in colorectal cancer patients with adjuvant chemotherapy using capecitabine: A randomized study + (Pregnant or lactating, or planning to beco … Pregnant or lactating, or planning to become pregnant; history of hypersensitivity or severe adverse reaction to fluoropyrimidines; serious concurrent disease (including interstitial pneumonia, pulmonary fibrosis, intestinal paralysis, ileus, poorly controlled diabetes, liver cirrhosis or hepatitis (type B or C), poorly controlled hypertension, history of myocardial infarction or unstable angina within past 6 months); active multiple primary cancer (disease-free less than 5 years); concurrent infectious disease; judged to be unsuitable for participation in the clinical study by the investigator for any other reasony by the investigator for any other reason)
Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial + (Presence of distant metastases; a previous history of salivary gland disorders, collagen tissue disease, diabetes, previous 131I therapy, or external radiation to the head or neck; or difficulty drinking a large amount of water.)
Pace et al. (2003): Neuroprotective Effect of Vitamin E Supplementation in Patient Treated With Cisplatin Chemotherapy + (Previous chemotherapeutic treatment or regimens including other neurotoxic drugs associated with cisplatin)
Pace et al. (2010): Vitamin E neuroprotection for cisplatin neuropathy + (Previous chemotherapeutic treatment or regimens including other neurotoxic drugs associated with cisplatin)
Lissoni et al. (2009): A Randomized Study of Chemotherapy versus Biochemotherapy with Chemotherapy plus Aloe arborescens in Patients with Metastatic Cancer + (Previous chemotherapy; brain metastasis; double tumour; lack of tolerance to polychemotherapy due to performance status, age or comorbidities)
Ertekin et al. (2004): Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study + (Previous history of autoimmune or chronic … Previous history of autoimmune or chronic inflammatory disease, radiotherapy and cytotoxic chemotherapy had previously been administered, use of medicine with the aim of mucositis prophylaxis, less than one-third of buccal mucosa was in the radiotherapy region, patient refused entryradiotherapy region, patient refused entry)
Salehi et al. (2015): Effect of Vitamin E on Oxaliplatin-induced Peripheral neuropathy Prevention: A Randomized Controlled Trial + (Previous history of peripheral neuropathy … Previous history of peripheral neuropathy or symptomatic peripheral neuropathy at entry into the study, received other chemotherapy regimens, currently receiving anticoagulants, platelet aggregation inhibitors, opioids, anticonvulsants, tricyclic antidepressants, and previous history of hemorrhagic strokeand previous history of hemorrhagic stroke)
Dale et al. (2001): Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects + (Previous history of radiation therapy, chemotherapy or surgery; WHO performance index below 70%; uncontrolled systematic diseases)
Arbabi-kalati et al. (2012): Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: A double-blind randomized clinical trial + (Previous or simultaneous radiotherapy in the head and neck region, including the nasopharynx, oropharynx, and larynx; previous head and neck surgery due to malignancy; use of dentures; pregnancy; infection)
Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (Previous radiotherapy for head and neck cancer, double cancers, diabetes mellitus)
Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer + (Previous radiotherapy in the head or neck area; functional disorders of the bone marrow, liver or kidneys; allergy to aloe)
Lin et al. (2010): Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: subgroup analysis of a double-blind, randomized study + (Previous radiotherapy of the head and neck; diabetes)
Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study + (Previous radiotherapy of the head and neck; diabetes mellitus)
Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (Previous radiotherapy of the head and neck; diabetes mellitus)
Puataweepong et. al (2009): The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: a double-blind placebo-controlled study + (Previous radiotherapy; allergies to aloe; diabetes mellitus; HIV)
Braik et al. (2014): Randomized trial of vitamin B6 for preventing hand-foot syndrome from capecitabine chemotherapy + (Previous treatment for HFS; hypersensitivity to pyridoxine; immunosuppression or positive human immunodefciency virus (HIV) serology)
Sangthawan et al. (2013): A randomized double-blind, placebo-controlled trial of zinc sulfate supplementation for alleviation of radiation-induced oral mucositis and pharyngitis in head and neck cancer patients + (Previously diagnosed with cancer, had other concomitant cancers, distant metastases or recurrent cancer, had undergone prior radiation therapy or chemotherapy, or had received drug containing zinc)
Scher et al. (2011): Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer + (Prior cytotoxic chemotherapy (except estra … Prior cytotoxic chemotherapy (except estramustine monotherapy), bone-seeking radioisotope therapy, prior untreated CNS involvement, or malignancy other than prostate cancer (except adequately treated basal or squamous cell skin cancer or any other cancer from which the individual had been disease free for > 5 years), history of hypercalcemia or vitamin D toxicity, active uncontrolled infection, symptomatic peripheral neuropathy of grade > 2, or hypersensitivity to any treatment component;use of calcium supplements higher than 500 mg and pharmacologic doses of vitamin D or its derivatives (> 400 U or 10 μg) vitamin D or its derivatives (> 400 U or 10 μg))
Kottschade et al. (2011): The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase 3 clinical trial + (Prior exposure to neurotoxic, not have had … Prior exposure to neurotoxic, not have had any of the following conditions: coronary artery disease, congestive heart failure, diabetes (requiring pharmacologic intervention), head or neck cancers, or a history of a hemorrhagic stroke, pregnant or nursing women, concomitant use of anticoagulants, platelet aggregation inhibitors, opioids, anticonvulsants, tricyclic antidepressants, other neuropathic pain medication agents, or vitamin E, not have been receiving radiationtamin E, not have been receiving radiation)
Gujral et al. (2001): Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers + (Prior radiation therapy; patients with distant metastasis, Kornovsky Index <70; altered hematological or biochemical parameters)
Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial + (Radical mastectomy)
Özdelikara et al. (2017): The Effect of Reflexology on Chemotherapy-induced Nausea, Vomiting, and Fatigue in Breast Cancer Patients + (Radiotherapy)
Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial + (Radiotherapy in the past year; food allergy; hypersensitivity to benzydamine, NSAIDs, or aloe; existing lesions in the oral cavity)

Olsen et al. (2001): The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy + (Radiotherapy of the brain or for gynaecological cancers)

Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) + (Received previous aromatase inhibitor trea … Received previous aromatase inhibitor treatment, had a history of rheumatoid arthritis, hypercalcemia or were taking excluded medications, unwilling to discontinue other oral supplements containing D3 and/or calcium;patients with osteoporosis in some cases; patients with osteoporosis in some cases)
Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer + (Receiving hospice care at intake, residing … Receiving hospice care at intake, residing in a nursing home or similar care facility, being bedridden, regularly using CAM similar to those used in the protocol (e.g., reflexology, foot massage, pedicure with massage), and participating in an experimental chemotherapy protocol. in an experimental chemotherapy protocol.)
Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial + (Receiving prior treatment for advanced or metastatic disease; taking 2000 IU/d or greater of vitamin D3, had symptomatic genitourinary stones within the past year, or were taking thiazide diuretics.)
Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial + (Receiving prior treatment for advanced or metastatic disease; taking 2000 IU/d or greater of vitamin D3, had symptomatic genitourinary stones within the past year, or were taking thiazide diuretics.)
Nasser et al. (2017): Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients + (Scleroderma, large breast with an inter-field of more than 25cm, or prior radiotherapy to the same breast, indication to lymph node irradiation)
Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer + (Second malignancy within 5 years (excludin … Second malignancy within 5 years (excluding basal or squamous cell carcinoma of the skin treated curatively); brain metastasis; nephrolithiasis within 10 years; chronic hypercalcemia (i.e., serum calcium >1.0 mg/dL the upper limit of normal); chronic gastrointestinal disease (i.e., malabsorption, surgery affecting absorption, and chronic ulcerative colitis); urinary protein >4 g/24 h; urinary calcium ≥500 mg/24 h; active angina, New York Heart Association class II–IV heart failure, or history of myocardial infarction within 6 month; uncontrolled infection; or hypersensitivity to polysorbate 80, use of digitalis, thiazide diuretics, calcium supplements, anticonvulsants, fluoride, and lithium was not allowed, use of steroids was permitted unless taken for prostate cancer;treatment with suramin, strontium, or other therapeutic radioisotopesor radiotherapy within 4 weeksutic radioisotopesor radiotherapy within 4 weeks)
Heggie et al. (2002): A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue + (Self-reported allergy to aloe vera; breast infection; indication for nodal irradiation)
Mansouri et al. (2016): The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial + (Suffering from any other underlying diseas … Suffering from any other underlying diseases; being addicted to cigars, tobacco and opioiddrugs; having a history of sensitivity to aloe vera; developing any kind of sensitivity to any material during the study; developing any acute condition during the study; and unwillingness to continue participation in the studyess to continue participation in the study)
Freedland et al. (2020): A Randomized Controlled Trial of a 6-month low carbohydrate intervention on disease progression in men with recurrent prostate cancer: Carbohydrate and Prostate Study 2 (CAPS2) + (Symptomatic metastatic disease; anticipati … Symptomatic metastatic disease; anticipation of needing secondary prostate cancer therapy within the next 6 months; current use of weight loss medications or enrollment in a diet/weight loss program; current therapy aimed at lowering testosterone levels (including GnRH agonist/antagonist; prior bilateral orchiectomy; oral anti-androgens, or 5-alpha reductase inhibitors; testosterone replacement was allowed but treatment should be stable during the entire study); already consuming an low carbohydrate diet; being vegetarian/vegan; weight loss >5% of body weight in the last 6 months based on self-report; medical comorbidities that in the opinion of the investigator limits the patient’s ability to complete the studys the patient’s ability to complete the study)
Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients + (The exclusion criteria included allergy to ginger, history of chemotherapy, history of other malignancy in women, reception of vitamin E and omega-3 before or concurrent with chemotherapy, chemotherapy intolerance and patients with stage 4 ovarian cancer.)
Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population? + (Those already receiving (or who had receiv … Those already receiving (or who had received in the past two months or who were intending to receive during the period of the study) either aromatherapy massage or reflexology from any practitioner and those unable to receive the intervention due to contraindications or precautions for either therapy.cations or precautions for either therapy.)
Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial + (Tumors that were not resectable by surgery, serious post-operative complications before starting supplementation, pathological diagnosis other than epithelial carcinoma (such as malignant lymphoma and sarcoma), and pathological stage 0 or IV)
Hoopfer et al. (2015): Three-arm randomized phase III trial: Quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy + (Uncontrolled diabetes; uncontrolled eating … Uncontrolled diabetes; uncontrolled eating disorders; acquired immunodeficiency syndrome, active lupus or scleroderma; known allergy to pure aloe; inability to complete the screening and informed consent procedures before receiving a total of 10 Gy of radiationre receiving a total of 10 Gy of radiation)
Cruciani et al. (2009): L-Carnitine Supplementation in Patients with Advanced Cancer and Carnitine Deficiency: A Double-Blind, Placebo-Controlled Study + (Uncontrolled or severe cardiovascular, pul … Uncontrolled or severe cardiovascular, pulmonary, or renal disease; current treatment with either chemotherapy or radiation therapy; encephalopathy or psychiatric disorder sufficient to compromise adherence to study methods or data collection; history of stroke, seizure, or primary or metastatic brain tumor; fewer than 60 days of concurrent use of recombinant erythropoietin, and known sensitivity to carnitineoietin, and known sensitivity to carnitine)
Keshavarzi et al. (2019): The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer + (Unwillingness to participate in the study, vaginal infection, estrogen therapy in the last 8 weeks, idiopathic vaginal bleeding, and disease recurrence based on the diagnosis recorded in the patient’s file)
Barton et al. (2013): The use of Ginkgo biloba for the prevention of chemotherapy-related cognitive dysfunction in women receiving adjuvant treatment for breast cancer, N00C9 + (Use of Ginkgo biloba in the last 6 months; antithrombotic therapy; significant concomitant diseases, e.g. diabetes)
Paur et al. (2017): Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA + (White blood cells outside normal reference … White blood cells outside normal reference window; Hb < 11 g/dL; prior endocrine treatment; <5 year life-expectancy; ECOG score >1; incontinence/urinary retention; critical comorbidity (e.g. cardiovascular disease, chronic obstructive pulmonary disease, insulin dependent diabetes mellitus, vasculitis, inflammatory bowel syndrome or other conditions with potential influence on radiation therapy)ions with potential influence on radiation therapy))
Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial + (With baseline serum corrected total calcium >10.5 mg/dl, phosphorous >4.5 mg/dl, magnesium >2.5 mg/dl, nephrolithiasis in the past 5 years, calcitriol therapy in the previous 30 days, hypersensitivity or inability to take oral calcitriol)
Ribeiro et al. (2017): Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer + (With liver, kidney, or chronic inflammator … With liver, kidney, or chronic inflammatory autoimmune diseases; with active infectious diseases; who were undergoing therapy with immunosuppressants; who were on vitamin or mineral supplementation; who had been on chemo- or radiation therapy in the previous 12 months; and who had been diagnosed as cognitively impairedhad been diagnosed as cognitively impaired)
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (Women of child-bearing age and patients with a mechanical obstruction to feeding, medical treatments inducing significant changes in patient metabolism or body weight, and a history of thromboembolism.)
Salihah et al. (2016): The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting + (Women with other malignancies, allergies to ginger, perfumes or cosmetics or who were undergoing concurrent radiotherapy)
Moslemi et al. (2014): Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial + (concurrent disease (diabetes mellitus, hyp … concurrent disease (diabetes mellitus, hypertension, autoimmunedisorder, chronic infllammation, cardiac disease, etc.), previously administration of cytotoxic chemotherapy or radiotherapy, patients refusal, infection of mouth and systemic infection and patients with interruption in the treatmentatients with interruption in the treatment)
Afonseca et al. (2013): Vitamin E for prevention of oxaliplatin-induced peripheral neuropathy: A pilot randomized clinical trial + (previous history of peripheral neuropathy … previous history of peripheral neuropathy or with symptomatic peripheral neuropathy at entry into the study. We also excluded patients who had received other chemotherapy regimens (except 5-fluorouracil alone) and those currently receiving gabapentin, carbamazepine, amitriptyline, amifostine or multivitaminsamitriptyline, amifostine or multivitamins)