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- Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial + (Breast cancer patients undergoing adjuvant radiotherapy after surgery)
- Zalat et al. (2020): Evaluation of the cardioprotective effects of l-carnitine and silymarin in cancer patients receiving anthracycline-containing chemotherapy + (Cancer patients receiving anthracycline chemotherapy in their protocol alone (without any cardioprotective agent), aged 20-60 years)
- Olsen et al. (2001): The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy + (Cancer patients undergoing radiotherapy)
- Dias et al. (2015): The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study + (Cancer patients, age ≥ 18 years, chemotherapy with cisplatin)
- Braik et al. (2014): Randomized trial of vitamin B6 for preventing hand-foot syndrome from capecitabine chemotherapy + (Cancer requiring capecitabine therapy; nev … Cancer requiring capecitabine therapy; never received capecitabine before; performance status of 0 to 2, according to the Eastern Cooperative Oncology Group (ECOG) classifcation; ife expectancy longer than 6 months; not being on vitamin B supplements; no prior HFS; no contraindication to chemotherapy (ie, patient had adequate bone marrow function, including an absolute neutrophil count > 1,500 cells/L and a platelet count > 100,000/L); adequate renal function (as indicated by a serum creatinine concentration < 1.5 mg/dL); adequate liver function (as indicated by a serum bilirubin concentration < 1.5 mg/dL, a transaminase level < 3 times the upper normal limit, and a serum albumin level > 2.5 mg/dL)pper normal limit, and a serum albumin level > 2.5 mg/dL))
- Arbabi-kalati et al. (2012): Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: A double-blind randomized clinical trial + (Chemotherapy treatment by a regimen with t … Chemotherapy treatment by a regimen with the same mucositis probability, including cyclophosphamide, doxorubicin, dacarbazine, gemcitabine, methotrexate, and 5-fluorouracil; Karnofsky performance status 60 or above; life expectancy equal to or more than 6 months; white blood cell (WBC) count equal to or more than 1500cell/ml platelet counts equal to greater than 100000 μLlet counts equal to greater than 100000 μL)
- Jeon et al. (2016): Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial + (Colon cancer patients aged 20 to 75 years, scheduled for elective laparoscopic colectomy under general anesthesia)
- Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy + (Completely functional erections before sur … Completely functional erections before surgery (corroborated by the partner and documented in the patient file), bilateral nerve-sparing radical retropubic prostatectomy (indicated on the surgical report) performed for pathologically proven organ-confined disease at least 6 months before screening, no adjuvant or neoadjuvant therapy for prostate cancer, no other treatment for ED before or after surgery, an undetectable postoperative prostate-specific antigen level, and involvement in a stable heterosexual relationship for at least 6 months before surgerynship for at least 6 months before surgery)
- Upadhyaya et al. (2017): Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differential thyroid cancer: A randomized-controlled trial + (Definite pathological diagnosis of differentiated thyroid cancer (DTC), presented to department for <sup>131</sup>I treatment)
- Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer + (Diagnosed with biopsy-proven Head-Neck-Cancer, treated with >4000-cGy intensity-modulated radiotherapy)
- Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (Diagnosed with cancer, may have received ≥ … Diagnosed with cancer, may have received ≥1 chemotherapy cycle, and were scheduled for at least three additional chemotherapy cycles, chemotherapy must have been given without concurrent radiation therapy or interferon and without planned interruption by radiation therapy or surgery, must have experienced nausea of any severity in any chemotherapy cycle before study enrollment, as well as scheduled to receive a 5-HT3 receptor antagonist (e.g., Zofran®, Kytril®, Navoban®, or Anzemet®) plus dexamathasone at all chemotherapy cycless dexamathasone at all chemotherapy cycles)
- Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients + (Diagnosed with noninflammatory breast cancer or carcinoma in situ and prescribed radiotherapy without concurrent chemotherapy at the University of Rochester Cancer Center)
- Fahimi et al. (2011): Evaluating the Effect of Zingiber Officinalis on Nausea and Vomiting in Patients Receiving Cisplatin Based Regimens + (Diagnosis of cancer and receiving cisplati … Diagnosis of cancer and receiving cisplatin-based regimens at least for two cycles of the chemotherapy, receiveing one of the standard antiemetic regimens [5-HT3 antagonist (granisetrone) and corticostreoid (hydrocortisone)], being able to swallow capsulesortisone)], being able to swallow capsules)
- Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial + (Diagnosis of head or neck cancer; age ≥18 years; Karnofsky performance > 70 (i.e. able to carry out normal activity and work))
- Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor + (Diagnosis of hematological tumor; white bl … Diagnosis of hematological tumor; white blood cell count 3–12×10<sup>9</sup>/l, platelet count ≥60×10<sup>9</sup> /l, absolute neutrophil count ≥10<sup>9</sup> /l; average score of the difficulty of mandibular impacted third molar extraction ≥14, patients had difficulties with tooth extraction; informed consent form signed by patientsd difficulties with tooth extraction; informed consent form signed by patients)
- Afonseca et al. (2013): Vitamin E for prevention of oxaliplatin-induced peripheral neuropathy: A pilot randomized clinical trial + (Eastern Cooperative Oncology Group (ECOG) … Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1, diagnosed with colorectal or gastric cancer and scheduled to receive oxaliplatin-based regimens (fluouracil, leucovarine and oxaliplatin, FLOX; 5-FU/leucovarine plus axaliplatine, FOLFOX; epirubicin, oxaliplatin and capecitabine EOX; and capecitabine plus oxaliplatin, XELOX) and capecitabine plus oxaliplatin, XELOX))
- Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation + (External beam radiotherapy treatment for head and neck cancer for the first time)
- Jacot et al. (2016): Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study + (Female patients with histologically confirmed primary early-stage breast cancer, treated in the last 12 months with adjuvant or neoadjuvant chemotherapy, and with an ECOG performance status of <2, vitamin D deficiency)
- Arslan et al. (2015): Oral Intake of Ginger for Chemotherapy-Induced Nausea and Vomiting Among Women With Breast Cancer + (Female with stage II or III breast cancer, … Female with stage II or III breast cancer, having received previous surgical treatment for breast cancer, currently receiving chemotherapy with adjuvant anthracycline (chemotherapy protocols: anthracycline, cyclophosphamide [Cytoxan®], doxorubicin [Adriamycin®], and 5-fluorouracil [Adrucil®]), receiving palonosetron-aprepitant antiemetic treatment, being at least in the second cycle of chemotherapy, and having experienced chemotherapy-induced nausea with a severity of 3 or higher during the previous cycles of 3 or higher during the previous cycles)
- Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer + (Female; over 18 years of age; newly diagnosed histologically proven early breast cancer (T1, T2 [<3 cm], N0, N1a, M0); received breast surgery; WHO status 0 or 1; willing to give written, informed consent; and able to complete questionnaires)
- Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients + (Females with approved ovarian cancer who underwent primary cytoreductive surgery, willingness to participate in the study.)
- Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial + (From 18 to 68 years, in complete remission of the disease and bone marrow (NCCN guidelines), with optimal kidney and liver functions)
- Dardano et al. (2012): The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with Iodine-131 + (Had undergone near-total thyroidectomy for DTC (differentiated thyroid cancer), at enrollment considered to be free of cancer metastases (serum thyroglubin level < 10ng/ml, negative anti-TG antibody titer and negative ultrasound neck examination)
- Halyard et al. (2007): Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4) + (Head and neck cancer patients scheduled to … Head and neck cancer patients scheduled to receive ≥2,000 cGy of external beam radiotherapy to ≥30% of the oral cavity; ≥18 years of age; life expectancy of ≥3 months (as determined by the physician’s judgment); Eastern Cooperative performance score of 0, 1, or 2; be able to take oral medications reliably and be alert and competent;</br>receiving amifostine and/or concomitant chemotherapy was allowednd/or concomitant chemotherapy was allowed)
- Najafizade et al. (2013): Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: A randomized placebo-controlled trial + (Head and neck cancers who were on schedule for radiotherapy with at least 2000 Gy ot >30% of oral cavity, with or without chemotherapy)
- Cruciani et al. (2012): L-Carnitine Supplementation for the Management of Fatigue in Patients With Cancer: An Eastern Cooperative Oncology Group Phase III, Randomized, Double-Blind, Placebo-Controlled Trial + (Hemoglobin ≥ 9 g/dL taken ≤ 4 weeks before registration)
- Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (Histological diagnosis of squamous cell ca … Histological diagnosis of squamous cell carcinoma of the oral cavity, the oropharynx, the hypopharynx, and/or the larynx; treated by radiotherapy alone, postoperative radiotherapy, radiochemotherapy alone, or postoperative radiochemotherapy; aged 18 to 80 years; no other cancer diagnosis in the past 5 years, except for basal cell and squamous cell carcinoma of the skinll and squamous cell carcinoma of the skin)
- Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (Histologically confirmed advanced stage tu … Histologically confirmed advanced stage tumor at any site, loss of >5% of ideal or preillness body weight in the previous 3 months with or without abnormal values of proinflammatory cytokines predictive of the onset of clinical cachexia, and a life expectancy ≥ 4 months, were eligible. Patients could be receiving concomitant antineoplastic chemotherapy or hormone therapy with palliative intent or supportive care.py with palliative intent or supportive care.)
- Ota et al. (2014): The effect of pyridoxine for prevention of hand-foot-syndrome in colorectal cancer patients with adjuvant chemotherapy using capecitabine: A randomized study + (Histologically confirmed colorectal cancer … Histologically confirmed colorectal cancer (adenocarcinoma); histological stage III colon cancer or rectosigmoid cancer resected with D2 or more lymph node dissection; age 20-80 years old; Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1; no prior chemotherapy or radiotherapy for target disease; oral intake is possible; preservation of primary organ function (white blood cell count ≥3,000 /mm3 and >12,000 /mm3, neutrophil count ≥1,500 /mm3, haemoglobin ≥9.0 g/dL, platelet count ≥100,000 /mm3; serum creatinine <1.5 mg/dL, serum total bilirubin <1.5 mg/dL, aspartate aminotransferase (ALT) <100 IU/L); able to start protocol treatment within 8 weeks of surgical procedurerotocol treatment within 8 weeks of surgical procedure)
- Vitale et al. (2020): ZeOxaNMulti Trial: A Randomized, Double-Blinded, Placebo-Controlled Trial of Oral PMA-Zeolite to Prevent Chemotherapy-Induced Side Effects, in Particular, Peripheral Neuropathy + (Histologically confirmed diagnosis of cancer, at least 18 years of age, oxaliplatin chemotherapy, and adequate hematologic parameters to allow chemotherapy)
- Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + (Histologically proven advanced lung cancer … Histologically proven advanced lung cancer, gastrointestinal tract tumor, breast cancer or</br>brain glioblastoma; measurable neoplastic lesions; progression on classical chemotherapy, radiotherapy or endocrine therapy or poor clinical conditions precluding chemotherapy; patients were eligible after at least 1 month from the last chemotherapy course; life expectancy <6 monthsotherapy course; life expectancy <6 months)
- Ertekin et al. (2004): Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study + (Histologically proven cancer of the head and neck (Karnofsky’s performance status ≥70) who were to receive curative radiotherapy or chemoradiotherapy)
- Lissoni et al. (2009): A Randomized Study of Chemotherapy versus Biochemotherapy with Chemotherapy plus Aloe arborescens in Patients with Metastatic Cancer + (Histologically proven metastatic cancer; histological diagnosis of lung cancer or gastrointestinal tumour; measurable lesions)
- Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial + (Histologically proven, advanced and irresectable adenocarcinoma of the pancreas (UICC Stage IV), had a Karnofsky performance status of >60)
- Mondal et al. (2014): Comparative study among glutamine, acetyl-L-carnitine, vitamin-E and methylcobalamine for treatment of paclitaxel-induced peripheral neuropathy + (Histology proven evidence of carcinomas of … Histology proven evidence of carcinomas of lung, breast and ovary and would be treated with 1<sup>st</sup> line or 2<sup>nd</sup> line chemotherapeutic drugs, patients receiving paclitaxel either as first line or second line chemotherapeutic drug, either as a single agent or in combinations and with baseline clinical evaluation negative for any existing peripheral neuropathy; when paclitaxel is administered as second like drug, the exact details of previous chemotherapeutic agents would be necessary; those who have already received platinum, vincristine would be included provided no peripheral neuropathy is detected at the time of enrollmentded no peripheral neuropathy is detected at the time of enrollment)
- Akiba et al. (2018): Vitamin D Supplementation and Survival of Patients with Non–small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial + (Histopathologically diagnosed as having NS … Histopathologically diagnosed as having NSCLC (adenocarcinoma, squamous cell carcinoma, adenosquamous carcinoma, or large cell lung carcinoma); with stage IA to IIIA; aged 20 to 75 years at entry; diagnosed and operated at any one of four Jikei University Hospitals at Shimbashi, Kashiwa, Chofu, and Katsushika; with tumor totally resected; discharged without major complications; and could visit the Jikei University Hospitals (Tokyo, Japan) and be followed-up for as long as possibleand be followed-up for as long as possible)
- Rastelli et al. (2011): Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial + (Hormone receptor positive invasive nonmeta … Hormone receptor positive invasive nonmetastatic breast cancer (Stage I-IIIB), had completed at least 8 weeks of anastrozole as adjuvant therapy prior to study entry, and were experiencing new or worsening musculoskeletal pain unrelated to any history of trauma;</br>serum 25OHD level between 10 and 29 ng/ml, serum calcium B10.3 mg/dl, and 24 h urine calcium excretion B250 mg/g creatinineine calcium excretion B250 mg/g creatinine)
- Moslemi et al. (2014): Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial + (Karnofsky’s performance status ≥70, receiving curative radiotherapy or chemoradiotherapy, planned treatment was at least 6000cGy total radiation dose of external beam radiotherapy to at least one third of the oral cavity)
- Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer + (Low-burden prostate cancer; choosing activ … Low-burden prostate cancer; choosing active surveillance for disease management; histologically documented prostate adenocarcinoma; extended pattern biopsy within 2 years of enrollment with a Gleason sum six or lower with no pattern four or five; no more than 33% of biopsy cores positive for cancer; no more than 50% of the length of a tumor core involved by carcinoma; three serum prostate-specific antige (PSA) levels done at least 2 weeks apart over the year prior to randomization; all PSA levels <10 ng/ml; life expectancy >3 months; ECOG (Eastern Cooperative Oncology Group) performance score <2Cooperative Oncology Group) performance score <2)
- Stephenson et al. (2000): The Effects of Foot Reflexology on Anxiety and Pain in Patients With Breast and Lung Cancer. + (Lung or breast cancer, 21 years or older; Patients who speak english and give informed consent)
- Sontakke et al. (2003): Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study + (Malignancy confirmed by histopathology, co … Malignancy confirmed by histopathology, combination chemotherapy including cyclophosphamide, occurrence of at least 2 episodes of vomiting in previous chemotherapy cycle and age above 18 years.</br>All patients received cyclophosphamide 500-1000 mg I.V. in combination with other chemotherapeutic agents.nation with other chemotherapeutic agents.)
- Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (Men with histopathologically or cytologica … Men with histopathologically or cytologically proven metastatic adenocarcinoma of the prostate with evidence of progression (the development of new metastatic lesions or rising PSA) despite standard hormonal management (orchiectomy, gonadotropin-releasing hormone agonist or antagonist including withdrawal of antiandrogens, if applicable; 6 weeks for bicalutamide, 4 weeks for flutamide or nilutamide) were eligible;</br>serum PSA ≥ 5.0 ng/mL, serum testosterone level ≤ 50 ng/dL, Eastern Cooperative Oncology Group performance status ≤ 2, life expectancy ≥ 3 months, age ≥ 18 years, patient agreement to use adequate contraception, and patient ability to give informed consent. patient ability to give informed consent.)
- Margalit et al. (2012): Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study + (Men, 40 to 84 years old at baseline (1982), who received radiation therapy)
- Mansourian et al. (2015): The effect of "curcuma Longa" topical gel on radiation -induced oral mucositis in patients with head and neck cancer + (Minimum age of 18 years, presence of head … Minimum age of 18 years, presence of head and neck cancer, minimum radiation dose of 50 Gy (the least dose resulting in mucositis), the ability of patient to use topical gel (by his/her or examiner’s report), minimally 50% of patient’s oral cavity in radiation field (according to the radiotherapist’s opinion)according to the radiotherapist’s opinion))
- Cruciani et al. (2009): L-Carnitine Supplementation in Patients with Advanced Cancer and Carnitine Deficiency: A Double-Blind, Placebo-Controlled Study + (Moderate to severe fatigue, a Karnofsky Pe … Moderate to severe fatigue, a Karnofsky Performance Status (KPS) score 14 of 50 or more, and carnitine deficiency; carnitine deficiency was defined as free carnitine less than 35 µmol/L for males or less than 25 µmol/L for females (normal range 35-67 and 25-55, respectively), or an acyl-carnitine ratio of more than 0.4 (acylcarnitine ratio 0.4 total acyl-carnitine - free acyl-carnitine/free acyl-carnitine)- free acyl-carnitine/free acyl-carnitine))
- Barton et al. (1998): Prospective evaluation of vitamin E for hot flashes in breast cancer survivors + (Must have had hot flashes for at least 1 m … Must have had hot flashes for at least 1 month with a frequency of at least 14 times per week. Women had to have a life expectancy of 6 months or more and a performance status of O or 1 on the Eastern Cooperative Oncology Group scale; use of the antiestrogen tamoxifen was allowed of the antiestrogen tamoxifen was allowed)
- Muecke et al. (2014): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology: follow-up analysis of the survival data 6 years after cessation of randomization + (NA)
- Muecke et al. (2013): Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology-a subgroup analysis of a multicenter, phase III trial + (NA)
- Gorgu et al. (2013): The effect of zinc sulphate in the prevention of radiation induced oral mucositis in patents with head and neck cancer + (NI)
- Ghoreishi et al. (2007): Effect of vitamin E on chemotherapy-induced mucositis and neutropenia in leukemic patients undergoing bone marrow transplantation + (NI)
- Rao et al. (2014): The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study + (NI)