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- Hoopfer et al. (2015): Three-arm randomized phase III trial: Quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy + ('''Perceived Symptoms''' The participants scored the severity of dryness, itchiness, burning, and pain using a 6-point Likert tool Patient symptom inventory: 0=none/not present; 1=mild; 2=discomfort; 3=distressing; 4=horrible; 5=excruciating)