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- Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial + (Evaluation of acute toxicity was done by t … Evaluation of acute toxicity was done by the radiation oncologist together with the patient in an interview. Diarrhea was assessed by increase of stools per day. Vomiting was assessed by frequency per day. Nausea was assessed by decrease of food intake.The fatigue syndrome was assessed by loss of activity.syndrome was assessed by loss of activity.)