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List of results

• Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain  + (Quality of life at baseline and 14-21 days after)
• Cohen et al. (2018): Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial  + (Quality of life via mental and physical functionality, including energy level/fatigue)
• Newling et al. (1995): Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group  + (Randomization until detection of recurrence)
• Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study  + (Rating the odour on a scale of 0 to 10 (0= “no smell” and 10= “the worst smell that one can imagine”) by the patient and the same nurse independently upon removal of old dressing)
• Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients  + (Redness of skin)
• Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients  + (Reducing acute nausea severity on day 1 of chemotherapy)
• Koyama et al. (2017): Intravenous Carnitine Administration in Addition to Parenteral Nutrition With Lipid Emulsion May Decrease the Inflammatory Reaction in Postoperative Surgical Patients  + (Reduction of complication rates: infectious, mechanical, overall after surgery)
• Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study  + (Reduction of the nausea score)
• Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial  + (Relapse-free survival = elapsed time from the date of randomization (ie, time from starting the study medication to the earliest date of cancer relapse or death due to any cause))
• Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer  + (Relaxation Scale (Baseline, 18 weeks pot surgery; 24 weeks post surgery))
• Mahmoodnia et al. (2017): Ameliorative effect of lycopene effect on cisplatin-induced nephropathy in patients  + (Renal toxicity: glomerular filtration rate cc/min (start of the study, day 7 of chemotherapy, day 21 of chemotherapy))
• Mahmoodnia et al. (2017): Ameliorative effect of lycopene effect on cisplatin-induced nephropathy in patients  + (Renal toxicity: serum creatinine mg/dL (start of the study, day 7 of chemotherapy, day 21 of chemotherapy))
• Mahmoodnia et al. (2017): Ameliorative effect of lycopene effect on cisplatin-induced nephropathy in patients  + (Renal toxicity: urea mg/dL (start of the study, day 7 of chemotherapy, day 21 of chemotherapy))
• Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS)  + (Reproductive hormone concentrations for estrone, estradiol, testosterone (free and total) and sex-hormone binding globulin)
• Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial  + (Requirements for supportive medication due to acute toxicities evaluated on T1 = day 3 of radiation to T6 = day 35 of radiation)
• Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy  + (Response rate (i.e. no emetic events, no emergency medication) over all 3 cycles for overall, acute (up to 24h after chemotherapy), and delayed (24-120h after chemotherapy) phase)
• Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy  + (Response rate (i.e. no emetic events, no emergency medication) for first cycle of chemotherapy (day 1-5 of chemotherapy) for overall, acute (up to 24h after chemotherapy), and delayed (24-120h after chemotherapy) phase)
• Ehrenpreis et al. (2005): A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial of Retinol Palmitate (Vitamin A) for Symptomatic Chronic Radiation Proctopathy  + (Response rate = at least two fewer chronic radiation-induced proctopathy symptoms (diarrhea, urge to defecate, rectal pain, tenesmus, rectal bleeding, fecal incontinence))
• Puri et al. (2010): Lycopene in treatment of high-grade gliomas: A pilot study  + (Response rate: complete response (CR), partial response (PR), progressive desease (PD), stable desease (SD))
• Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients  + (Results of CT scans in terms of the presence of metastasis at different times)
• Howells et al. (2011): Phase I randomised double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases - safety, pharmacokinetics and pharmacodynamics  + (Resveratrol pharmacokinetics in blood (1) and concentration in liver tissue (2): (1) Patients’ plasma was analysed by HPLC-MS/MS for resveratrol. (2) Resveratrol was quantified in tumor and normal adjacent hepatic tissues.)
• Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial  + (Salivary absorbed dose during the first 24 h after 131I ingestion, calculated from the 131I activity administered, saliva retention time and salivary gland mass (determined by CT))
• Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial  + (Salivary absorbed sose, calculated from the 131I activity administered, saliva retention time and salivary gland mass (determined by CT))
• Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial  + (Salivary activity)
• Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial  + (Salivary cumulated activities in first 24h after 131I ingestion divided by total cumulated activities)

• Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy  + (Satisfaction with sexual function with semi-structured interview)

• Upadhyaya et al. (2017): Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differential thyroid cancer: A randomized-controlled trial  + (Scintigraphic parameters: Uptake fraction (UF); Uptake index (UI), Excretion fraction (EF), Excretion ratio (ER)))
• Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor  + (Score range = 0 (no pain) to 10 (intolerab … Score range = 0 (no pain) to 10 (intolerable severe pain)</br></br>No pain: 0–1 points for no pain or little pain or pain hard to feel; </br></br>Mild: 2–3 points for tolerable pain that did not affect sleep; </br></br>Moderate: 3–6 points for pain that altered normal daily activities and sleep; </br></br>Severe: ≥7 points for intolerable pain, patients took ibuprofen sustained release capsule or return for a visitined release capsule or return for a visit)
• Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study  + (Scoring of vomitting)
• Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population?  + (Secondary complaints according to self-report)
• Grimison et al. (2020): Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial  + (Self-developed measurement instrument: structured checklist of cannabinoid-specific adverse events)
• Grimison et al. (2020): Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial  + (Self-reported "complete response" ("no vom … Self-reported "complete response" ("no vomiting", "no clinically significant nausea", defined as nausea <2 on a 10-point scale, and "no use of emergency medication") during the acute (0-24 h), delayed (24-120 h) and general phase (0-120 h) of chemotherapy with diary day -1 to 6 of each cycle)therapy with diary day -1 to 6 of each cycle))
• Kottschade et al. (2011): The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase 3 clinical trial  + (Sensory Neuropathie)
• Bairati et al. (2006): Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients  + (Separately for cause of death: any cause, initial cancer, second primary cancer, any cancer, noncancer causes Median follow-up: - intervention arm: 6.4 years - placebo arm: 6.6 years)
• Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS)  + (Serum 25(OH)D)
• Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer  + (Serum PSA)
• Büntzel et al. (2010): Selenium Substitution During Radiotherapy of Solid Tumours - Laboratory Data from Two Observation Studies in Gynaecological and Head and Neck Cancer Patients  + (Serum concentration and whole blood concentration)
• Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial  + (Serum creatinine level and blood urea nitrogen test for renal function assessment and aspartate aminotransferase and alanine transaminase for liver function assessment, recorded daily)
• Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis  + (Serum transferrin level)
• Jyothirmayi et al. (1996): Efficacy of Vitamin A in the Prevention of Locoregional Recurrence and Second Primaries in Head and Neck Cancer  + (Serum vitamin A level)
• Sangthawan et al. (2015): Effects of zinc sulfate supplementation on cell-mediated immune response in head and neck cancer patients treated with radiation therapy  + (Serum zinc level)
• Henning et al. (2015): Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy  + (Serum-PSA-Level evaluated by high performance liquid chromatography and ELISA analysis)
• Panahi et al. (2012): Effect of Ginger on Acute and Delayed Chemotherapy-Induced Nausea and Vomiting: A Pilot, Randomized, Open-Label Clinical Trial  + (Severity (Rhodes Index Scores) of Nausea, Vomiting, and Retching)
• Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study  + (Severity of nausea at T1 (acute) and T2 (delayed) (0-10, 0 = none, 10 = strongest possible nausea) Nausea was defined a disorder characterized by a queasy sensation and/or the urge to vomit)
• Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer  + (Severity of nausea, incidence of vomiting ( day 1 of chemotherapy to day 5 of chemotherapy))
• Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients  + (Severity of radiodermatitis (skin measurements weekly after the 5th radiationtherapy session))
• Moslemi et al. (2014): Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial  + (Severity, duration and commencement of radiotherapy induced mucositis)
• Emami et al. (2014): Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of green tea in preventing acute gastrointestinal complications due to radiotherapy  + (Severity: FLIE mild = ≤6; moderate = 7-12; … Severity: FLIE</br>mild = ≤6;</br>moderate = 7-12;</br>severe = 13-15</br></br>Frequency: Diary entries</br>All participants recorded daily in a diary (number, consistency of stools, occurrence of symptoms such as nausea, vomiting and gastrointestinal cramps) from day 1 of the 2nd week to the end of the 5th weekof the 2nd week to the end of the 5th week)
• Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment  + (Short forms of the PROMIS: Scale for physical functioning (study weeks 3, 5, 11))
• Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study  + (Side effects)
• Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy  + (Side effects (continuous until 30 days after last intervention))