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- Mahmoodnia et al. (2017): Ameliorative effect of lycopene effect on cisplatin-induced nephropathy in patients + (Renal toxicity: glomerular filtration rate cc/min (start of the study, day 7 of chemotherapy, day 21 of chemotherapy))
- Mahmoodnia et al. (2017): Ameliorative effect of lycopene effect on cisplatin-induced nephropathy in patients + (Renal toxicity: serum creatinine mg/dL (start of the study, day 7 of chemotherapy, day 21 of chemotherapy))
- Mahmoodnia et al. (2017): Ameliorative effect of lycopene effect on cisplatin-induced nephropathy in patients + (Renal toxicity: urea mg/dL (start of the study, day 7 of chemotherapy, day 21 of chemotherapy))
- Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) + (Reproductive hormone concentrations for estrone, estradiol, testosterone (free and total) and sex-hormone binding globulin)
- Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial + (Requirements for supportive medication due to acute toxicities evaluated on T1 = day 3 of radiation to T6 = day 35 of radiation)
- Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy + (Response rate (i.e. no emetic events, no emergency medication) over all 3 cycles for overall, acute (up to 24h after chemotherapy), and delayed (24-120h after chemotherapy) phase)
- Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy + (Response rate (i.e. no emetic events, no emergency medication) for first cycle of chemotherapy (day 1-5 of chemotherapy) for overall, acute (up to 24h after chemotherapy), and delayed (24-120h after chemotherapy) phase)
- Ehrenpreis et al. (2005): A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial of Retinol Palmitate (Vitamin A) for Symptomatic Chronic Radiation Proctopathy + (Response rate = at least two fewer chronic radiation-induced proctopathy symptoms (diarrhea, urge to defecate, rectal pain, tenesmus, rectal bleeding, fecal incontinence))
- Puri et al. (2010): Lycopene in treatment of high-grade gliomas: A pilot study + (Response rate: complete response (CR), partial response (PR), progressive desease (PD), stable desease (SD))
- Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients + (Results of CT scans in terms of the presence of metastasis at different times)
- Howells et al. (2011): Phase I randomised double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases - safety, pharmacokinetics and pharmacodynamics + (Resveratrol pharmacokinetics in blood (1) and concentration in liver tissue (2): (1) Patients’ plasma was analysed by HPLC-MS/MS for resveratrol. (2) Resveratrol was quantified in tumor and normal adjacent hepatic tissues.)
- Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial + (Salivary absorbed dose during the first 24 h after 131I ingestion, calculated from the 131I activity administered, saliva retention time and salivary gland mass (determined by CT))
- Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial + (Salivary absorbed sose, calculated from the 131I activity administered, saliva retention time and salivary gland mass (determined by CT))
- Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial + (Salivary activity)
- Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial + (Salivary cumulated activities in first 24h after 131I ingestion divided by total cumulated activities)
- Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy + (Satisfaction with sexual function with semi-structured interview)
- Upadhyaya et al. (2017): Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differential thyroid cancer: A randomized-controlled trial + (Scintigraphic parameters: Uptake fraction (UF); Uptake index (UI), Excretion fraction (EF), Excretion ratio (ER)))
- Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor + (Score range = 0 (no pain) to 10 (intolerab … Score range = 0 (no pain) to 10 (intolerable severe pain)</br></br>No pain: 0–1 points for no pain or little pain or pain hard to feel; </br></br>Mild: 2–3 points for tolerable pain that did not affect sleep; </br></br>Moderate: 3–6 points for pain that altered normal daily activities and sleep; </br></br>Severe: ≥7 points for intolerable pain, patients took ibuprofen sustained release capsule or return for a visitined release capsule or return for a visit)
- Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study + (Scoring of vomitting)
- Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population? + (Secondary complaints according to self-report)
- Grimison et al. (2020): Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial + (Self-developed measurement instrument: structured checklist of cannabinoid-specific adverse events)
- Grimison et al. (2020): Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial + (Self-reported "complete response" ("no vom … Self-reported "complete response" ("no vomiting", "no clinically significant nausea", defined as nausea <2 on a 10-point scale, and "no use of emergency medication") during the acute (0-24 h), delayed (24-120 h) and general phase (0-120 h) of chemotherapy with diary day -1 to 6 of each cycle)therapy with diary day -1 to 6 of each cycle))
- Kottschade et al. (2011): The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase 3 clinical trial + (Sensory Neuropathie)
- Bairati et al. (2006): Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients + (Separately for cause of death: any cause, initial cancer, second primary cancer, any cancer, noncancer causes Median follow-up: - intervention arm: 6.4 years - placebo arm: 6.6 years)
- Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) + (Serum 25(OH)D)
- Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer + (Serum PSA)
- Büntzel et al. (2010): Selenium Substitution During Radiotherapy of Solid Tumours - Laboratory Data from Two Observation Studies in Gynaecological and Head and Neck Cancer Patients + (Serum concentration and whole blood concentration)
- Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial + (Serum creatinine level and blood urea nitrogen test for renal function assessment and aspartate aminotransferase and alanine transaminase for liver function assessment, recorded daily)
- Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (Serum transferrin level)
- Jyothirmayi et al. (1996): Efficacy of Vitamin A in the Prevention of Locoregional Recurrence and Second Primaries in Head and Neck Cancer + (Serum vitamin A level)
- Sangthawan et al. (2015): Effects of zinc sulfate supplementation on cell-mediated immune response in head and neck cancer patients treated with radiation therapy + (Serum zinc level)
- Henning et al. (2015): Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy + (Serum-PSA-Level evaluated by high performance liquid chromatography and ELISA analysis)
- Panahi et al. (2012): Effect of Ginger on Acute and Delayed Chemotherapy-Induced Nausea and Vomiting: A Pilot, Randomized, Open-Label Clinical Trial + (Severity (Rhodes Index Scores) of Nausea, Vomiting, and Retching)
- Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study + (Severity of nausea at T1 (acute) and T2 (delayed) (0-10, 0 = none, 10 = strongest possible nausea) Nausea was defined a disorder characterized by a queasy sensation and/or the urge to vomit)
- Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer + (Severity of nausea, incidence of vomiting ( day 1 of chemotherapy to day 5 of chemotherapy))
- Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients + (Severity of radiodermatitis (skin measurements weekly after the 5th radiationtherapy session))
- Moslemi et al. (2014): Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial + (Severity, duration and commencement of radiotherapy induced mucositis)
- Emami et al. (2014): Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of green tea in preventing acute gastrointestinal complications due to radiotherapy + (Severity: FLIE mild = ≤6; moderate = 7-12; … Severity: FLIE</br>mild = ≤6;</br>moderate = 7-12;</br>severe = 13-15</br></br>Frequency: Diary entries</br>All participants recorded daily in a diary (number, consistency of stools, occurrence of symptoms such as nausea, vomiting and gastrointestinal cramps) from day 1 of the 2nd week to the end of the 5th weekof the 2nd week to the end of the 5th week)
- Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment + (Short forms of the PROMIS: Scale for physical functioning (study weeks 3, 5, 11))
- Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study + (Side effects)
- Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy + (Side effects (continuous until 30 days after last intervention))
- Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study + (Side effects included diarrhea, constipation, heartburn.)
- Nasser et al. (2017): Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients + (Skin toxicity)
- Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (Sleep quality)
- Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (Sleep quality and mood (no information on survey))
- Campos et al. (2011): Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy + (Specific questionnaires were used: FACIT- … Specific questionnaires were used: </br>FACIT-F that assesses self-reported QOL and fatigue with total score ranging from 0 to 160 </br>FACIT-ES that includes a subspace evaluating menopausal symptoms, among other components that are totaled to provide an overall score ranging from 0 to 180ide an overall score ranging from 0 to 180)
- Mayne et al. (2001): Randomized Trial of Supplemental beta-Carotene to Prevent Second Head and Neck Cancer + (Specific results for: a) age of death b) stratification with regard to smoking history (less than 25 pack/year vs. more than 25 pack/year c) stratification with regard to plasma beta-carotene)
- Kessels et al. (2017): Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma A Randomized Clinical Trial + (Specifically tumor clearance, i.e. the proportion of patients with complete histological tumor clearance after eight weeks (time point 3))
- Kessels et al. (2017): Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma A Randomized Clinical Trial + (Specifically tumor size, examination after three weeks (time point 1), six weeks (time point 2) and eight weeks (time point 3))
- Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain + (Specification NRS: Constipation NRS)
- Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (Specification NRS: constipation NRS)