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List of results

• Yap et al. (2017): Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: a randomized clinical trial  + (Baseline Start of the 2nd, 4th, 5th, 8th cycle + end of study)

• Barton et al. (2013): The use of Ginkgo biloba for the prevention of chemotherapy-related cognitive dysfunction in women receiving adjuvant treatment for breast cancer, N00C9  + (Baseline (before first or second cycle of … Baseline (before first or second cycle of chemotherapy), during chemotherapy, at the first visit postchemotherapy (generally 1 month after chemotherapy and commensurate with the completion of the study agent), and at 6, 12, 18, and 24 months after chemotherapy. Potential side effects were evaluated at each data point.effects were evaluated at each data point.)
• Salehi et al. (2015): Effect of Vitamin E on Oxaliplatin-induced Peripheral neuropathy Prevention: A Randomized Controlled Trial  + (Baseline (prior to chemotherapy), prior to every chemotherapy cycle and after 6. chemotherapy cycle)
• Ferreira et al. (2004): Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: A double-blind randomized trial  + (Baseline + 7 weeks of radiotherapy Median follow-Up in months: 12 (range: 2–24))
• Kottschade et al. (2011): The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase 3 clinical trial  + (Baseline, before each chemotherapy, 1 month and 6 months post-chemotherapy)
• Okabayashi et al. (2020): L-Carnitine Improves Postoperative Liver Function in Hepatectomized Patients  + (Baseline: 2 weeks before surgery T1: After surgery)
• Stratton et al. (2010): Oral Selenium Supplementation Has No Effect on Prostate- Specific Antigen Velocity in Men Undergoing Active Surveillance for Localized Prostate Cancer  + (Baseline; then every 3 months for 5 years)
• Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer  + (Before randomization: T1: 1 week after the last intervention; T2: 6 weeks after the last intervention)
• Dardano et al. (2012): The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with Iodine-131  + (Blood samples were drawn just before and at various intervals after ¹³¹I therapy (at baseline and at 7, 17, 28, and 90 days).)
• Goossens et al. (2016): Phase III randomised chemoprevention study with selenium on the recurrence of non-invasive urothelial carcinoma. The SELEnium and BLAdder cancer Trial  + (Described unclear)
• Moslemi et al. (2014): Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial  + (During treatment until 2 weeks after treatment, weekly)
• Nasser et al. (2017): Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients  + (Each week of treatment (T1-T5) Follow-Up: 2 weeks after treatment end)
• Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators  + (Every 4 weeks)
• Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis  + (Follow-up period of 5 years (followed up on once a month during the first year of study and then every 3 months thereafter))
• Newling et al. (1995): Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group  + (Follow-up: every 3 months in the first year, thereafter every 6 months)
• Sangthawan et al. (2015): Effects of zinc sulfate supplementation on cell-mediated immune response in head and neck cancer patients treated with radiation therapy  + (Follow-ups: at the first month after completion of radiation therapy, every 3 month to 2 year, every 6 month to 5 year, annually thereafter)
• Rao et al. (2014): The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study  + (Mucositis was assessed before the start of the radiation treatment and at weekly intervals)
• Muecke et al. (2014): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology: follow-up analysis of the survival data 6 years after cessation of randomization  + (NA)
• Muecke et al. (2013): Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology-a subgroup analysis of a multicenter, phase III trial  + (NA)
• Afonseca et al. (2013): Vitamin E for prevention of oxaliplatin-induced peripheral neuropathy: A pilot randomized clinical trial  + (NI)
• Walsh et al. (2010): Use of alpha,25-dihydroxyvitamin D3 treatment to stimulate immune infiltration into head and neck squamous cell carcinoma  + (NI)
• Dias et al. (2015): The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study  + (NI)
• Yekta et al. (2012): Ginger as a miracle against chemotherapy-induced vomiting  + (NI)
• Sontakke et al. (2003): Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study  + (NI)
• Ansari et al. (2016): Efficacy of Ginger in Control of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients Receiving Doxorubicin- Based Chemotherapy  + (NI)
• Sanaati et al. (2016): Effect of Ginger and Chamomile on Nausea and Vomiting Caused by Chemotherapy in Iranian Women with Breast Cancer  + (NI)
• Salihah et al. (2016): The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting  + (NI)
• Raei et al. (2013): Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients  + (NI)
• Özdelikara et al. (2017): The Effect of Reflexology on Chemotherapy-induced Nausea, Vomiting, and Fatigue in Breast Cancer Patients  + (NI)
• Özdelikara et al. (2017): The effect of reflexology on the quality of life with breast cancer patients  + (NI)
• Stephenson et al. (2000): The Effects of Foot Reflexology on Anxiety and Pain in Patients With Breast and Lung Cancer.  + (NI)
• Stephenson et al. (2017): Partner-delivered reflexology: Effects on cancer pain and anxiety.  + (NI)
• Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial  + (NI)
• Laali et al. (2020): Effect of Selenium on Incidence and Severity of Mucositis during Radiotherapy in Patients with Head and Neck Cancer  + (Oral mucositis T0: Baseline Follow up: weekly for 7 weeks Selenium level T0: Baseline T1: End of radiation)
• Howells et al. (2011): Phase I randomised double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases - safety, pharmacokinetics and pharmacodynamics  + (Patients ingested the formulation pre-oper … Patients ingested the formulation pre-operatively daily for a minimum of 10 and a maximum of 21 days, dependent upon surgical scheduling. Plasma samples for PK assessment were obtained on days 1 and 2, and on the day of surgical resection. Plasma for PD assessment was obtained pre-dose, immediately prior to, and during surgery. Diseased and normal adjacent hepatic tissue was resected 6-7 h after the last dose.ue was resected 6-7 h after the last dose.)
• Büntzel et al. (2010): Selenium Substitution During Radiotherapy of Solid Tumours - Laboratory Data from Two Observation Studies in Gynaecological and Head and Neck Cancer Patients  + (Selenium concentration measured at baseline, after 4 weeks, after the end of radiotherapy and 6 weeks after the end of radiotherapy Overall duration: 7 weeks of radiotherapy)
• Büntzel et al. (2010): Limited effects of selenium in the prevention of radiation-associated toxicities - results of a randomized study in head neck cancer patients  + (Selenium concentration measured at baseline, after 4 weeks, after the end of Radiotherapy and 6 weeks after the end of Radiotherapy Outcome assessed at baseline and then once a week and 6 weeks after Radiotherapy)
• Karp et al. (2012): Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597  + (Study period: October 6, 2000 - November 5, 2009)
• Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer  + (T0 = Baseline T1 = after 6 month)
• Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment  + (T0 = Baseline T1 = week 1; T2: week 2; T3: week 3; T4: week 4)
• Campos et al. (2011): Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy  + (T0 = Baseline T1 = Day 21 (after phase 1) T2 = Day 49 (after phase 2))
• Upadhyaya et al. (2017): Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differential thyroid cancer: A randomized-controlled trial  + (T0: -4h radioiodine therapy T1: after 6 months)
• Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population?  + (T0: 1st intervention T1: 2nd intervention T2: 3rd intervention T3: 4th intervention)