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- Gujral et al. (2001): Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers + (Enzyme-arm: no evaluation N=3, complete/go … Enzyme-arm: no evaluation N=3, complete/good response in N=32/16, moderate response N=1, poor/no response/progress N=1 </br></br>Control-arm: no evaluation N=4, complete/good response N=23/15, moderate response N=5, poor/no response/progress N=0, </br></br>but arm difference is not statistically significant (p=0.23) is not statistically significant (p=0.23))