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- Kasseroller et al. (2003): Efficacy and tolerability of proteolytic enzymes as an anti-inflammatory agent in lymphoedema after axillary dissection due to mammary cancer + (Mean tension of the ill arm after 45 days: Enzyme-arm = 0.4; Placebo-arm = 0.5 Both arms show a similar decrease of tension in the ill arm, but but the decrease was a little bit greater in the enzyme-arm (p=NI).)