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- Kasseroller et al. (2003): Efficacy and tolerability of proteolytic enzymes as an anti-inflammatory agent in lymphoedema after axillary dissection due to mammary cancer + (Mean volume of the upper ill arm at day 45 … Mean volume of the upper ill arm at day 45:</br></br>Enzyme-arm = 4mm;</br>Placebo-arm = 3.4mm</br></br>Both arms show similiar developement of skin thickness after 45 days. Similar development in the lower arm, hand and third finger. There is a slight advantage for the enzyme-arm for upper ill arm and lower arm; (p=NI).m for upper ill arm and lower arm; (p=NI).)