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- Campos et al. (2011): Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy + (No difference between the arms. Significa … No difference between the arms. </br>Significantly better sleep within the guarana arm compared to baseline.</br>Better sleep quality after the use of guarana only in the day 49 comparison and in guarana-placebo arm of the intragroup analysis</br>Intergroup comparison of guarana and placebo: </br>Day 21: p = .19</br>Day 49: p .05nd placebo: Day 21: p = .19 Day 49: p .05)