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- Hoopfer et al. (2015): Three-arm randomized phase III trial: Quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy + (The univariate analysis according to treat … The univariate analysis according to treatment arm at 1 week after radiation showed placebo cream had an increased CSSP effect of 0.61 (p=0.0845) greater than that for powder. Also, aloe cream had an increased CSSP effect of 0.80 greater than that for powder (p=0.0283).0 greater than that for powder (p=0.0283).)