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- Dale et al. (2001): Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects + (There was a statistically significant (p&l … There was a statistically significant (p<0.001) improvement in favour of the enyzme-arm: enzyme arm = 0.97 (0.82); placebo-arm = 1.68 (0.87). The treatment effect was observed from 1 week after start of radiation therapy until the last follow-up visit 5 month after intervention.t follow-up visit 5 month after intervention.)