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- Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial + (Treatment interruptions (mean days) due to … Treatment interruptions (mean days) due to acute toxicity were 2.44 days in the enzyme arm and 1.46 days in the placebo arm. 52 out of 56 patients (92.8%) finished the entire radiation treatment as planned; 4 (7.2%) patients finished radiation prematurely (enzyme arm: 2; placebo arm: 2 patients). (enzyme arm: 2; placebo arm: 2 patients).)