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- Dale et al. (2001): Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects + (78.3% of the enzyme arm showed no skin rea … 78.3% of the enzyme arm showed no skin reactions or faint erythema. </br>40.0% of the control-arm showed moderate to bright erythema or patchy moist desquamation. 15% of the control-arm showed confluent moist desquamation and pitting oedema. 5% of the enyzme-arm showed the same symptoms. 1 patient (control-arm) showed frank skinulceration.(control-arm) showed frank skinulceration.)