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List of results

Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer + (No difference between treatment arms in the rate of PSA response, no difference in the median time to PSA response)
Frankling et al. (2021): ‘Palliative-D’ - Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial + (No difference in survival time between the two treatment arms at any timepoint, after 4 weeks (p=0.36), 8 weeks (p=0.09) or 12 weeks (p=0.08))
Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (No differences between arms after 5 weeks (no p-value))
Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (No differences between arms after 5 weeks (no p-value).)
Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (No differences between arms after 5 weeks (no p-value).)
Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (No differences between arms after 5 weeks (no p-value).)
Koyama et al. (2017): Intravenous Carnitine Administration in Addition to Parenteral Nutrition With Lipid Emulsion May Decrease the Inflammatory Reaction in Postoperative Surgical Patients + (No differences between the arms for complications (in both arms n=2 each; p=0.715) or type of complication (p>0.05))
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (No differences for sleepiness (p=0.3166), anxiety (p=0.9163) and xerostomia (p=0.8341))
Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…) + (No differences for weight or weight loss after 6 weeks (no statistical values))
Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial + (No grade 4 was identified in both arms. … No grade 4 was identified in both arms. The mean time between the start of radiation and onset of early signs of mucositis was 15.6 days in theAloe arm and 15.8 days in the placebo arm, but the difference was not statistically significant (p = 0.97).The mean duration between beginning of radiation and maximum mucositis grade occurrence was 23.3 days in the Aloe arm and 23.5 days in the placebo arm, but the difference was not statistically significant (p = 0.98).There was no significant difference between the arms in terms of mucositis grade changes over time (p = 0.09).ositis grade changes over time (p = 0.09).)
Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial + (No information)
Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + (No objective tumor regression was achieved … No objective tumor regression was achieved in the control arm. In contrast, 2/24 (8%) patients of the aloe arm had partial response. Stable disease was obtained in 12/24 (50%) patients of the aloe arm and in only 7/26 (27%) patients of the control arm. There were significantly fewer patients with non-progressive disease in the aloe arm (14/24) compared to control arm (7/26), p<0.05. 7/24 (42%) patients of the aloe arm and 19/26 (73%) patients of the control arm had progressive disease.s of the control arm had progressive disease.)
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (No sign. difference between arms (p=NI))
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (No sign. difference between arms (p=NI))
Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain + (No significance calculated as primary endpoint showed no effects (to control for alpha error). Only unadjusted values: advantage for intervention arm over placebo arm for sleep disturbance)
Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain + (No significance calculated as primary endpoint showed no effects (to control for alpha error).)
Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain + (No significance calculated as primary endpoint showed no effects (to control for alpha error).)
Marx et al. (2017): The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial + (No significant associations (p>0.05))
Frankling et al. (2021): ‘Palliative-D’ - Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial + (No significant difference)
Frankling et al. (2021): ‘Palliative-D’ - Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial + (No significant difference)
Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies + (No significant difference after 5 weeks * … No significant difference after 5 weeks* Sativex arm = 7.2% vs. placebo arm = 9.5% (median difference = −1.84%; CI: −6.19%, 1.50%; p=0.274, not significant)Subgroup analysis with US population * shows effects for Sativex arm (p=0.03), especially for patients under 65 years of ageecially for patients under 65 years of age)
Bossi et al. (2017): A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high-dose cisplatin + (No significant difference between arms. A … No significant difference between arms. At cycle 1: worsening of the BFI score was smaller with ginger than placebo (treatment difference -0.23, 95% CI: -0.97 to 0.51). At cycle 2: the situation was different: worsening with ginger was slightly higher than with placebo (treatment difference 0.09, 95% CI –0.71 to 0.89). During both cycles, differences in BFI scores were negligible.differences in BFI scores were negligible.)
Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia + (No significant difference between patients who did develop aromatase inhibitor-induced arthralgia and those patients who did not develop aromatase inhibitor-induced arthralgia)
Heggie et al. (2002): A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue + (No significant difference between the arms at each assessed time point (p = 0.15-0.94); this was also the case with the duration of the reaction.)
Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck + (No significant difference for the 7 weeks of intervention)
Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study + (No significant difference ginger vs. placebo: 10.6% vs. 8.5% (p=0.78) on day 1 of chemotherapy No significant group differences (p>0.05) on day 2-5 of chemotherapy)
Marx et al. (2017): The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial + (No significant difference in all cycles (p>0.05))
Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain + (No significant difference in median improv … No significant difference in median improvement for ITT after 5 weeks:* Intervention 10.7% vs. placebo 4.5%; treatment difference = 3.41%, 95% CI: 0.00% - 8.16%; p=0.0854; Significant difference for per protocol analysis after 5 weeks: * Intervention 15.5% vs. placebo 6.3%; treatment difference = 5.49%, 95% CI: 0.00% - 11.11%; p=0.0378 = 5.49%, 95% CI: 0.00% - 11.11%; p=0.0378)
Braga et al. (2015): Effect of Zinc Supplementation on Serological Response to Vaccination Against Streptococcus Pneumoniae in Patients Undergoing Chemotherapy for Colorectal Cancer + (No significant difference in the rate of seroconversion against vaccine antigens according to selected antigens (PS1, PS5, PS6, PS9, PS14, PS18))

Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (No significant differences)
Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (No significant differences)
Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial + (No significant differences)
Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial + (No significant differences)
Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial + (No significant differences)
Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial + (No significant differences)
Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial + (No significant differences)
Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial + (No significant differences)

Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients + (No significant differences (nausea, vomiting, depression, shortness of breath, memory, appetite, diarrhea, urination, skin, sleep, fatigue, activity, mood, work, relationships, walking, quality of life))
Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study + (No significant differences before therapy, in the last week: significant difference of serum zinc levels between the two arm: intervention arm: 20.5 (39.9) vs. placebo arm: -1.5 (39.1), p = 0.02)
Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (No significant differences between THC:CBD arm/THC arm and placebo arm)
Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (No significant differences between THC:CBD arm/THC arm and placebo arm.)
Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer + (No significant differences between all three arms at T1 (18 weeks post surgery) and T2 (24 weeks post surgery))
Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer + (No significant differences between all thr … No significant differences between all three arms at T1 (18 weeks post surgery). Significant better values for intervention 1 than Intervention 2 in the total scale as well as in the subscale “functional well-beeing” at T2 (24 weeks post surgery) (total scale: intervention 1: 118.60 [114.93,112.26], intervention 3: 111.70 [108.10,115.30]; p=0.03, “functional wellbeing”: intervention 1: 23.17 [22.01,24.33], intervention 3: 21.04 [19.90,22.17]; p=0.03). No significant differences between the other arms.ficant differences between the other arms.)
Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer + (No significant differences between all three arms at T1 (18 weeks post surgery) and T2 (24 weeks post surgery).)
Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain + (No significant differences between arms after 3 weeks and 5 weeks (p=0.6410; p=0.4217).)
Inglis et al. (2020): Effects of High-Dose Vitamin D Supplementation on Phase Angle and Physical Function in Patients with Prostate Cancer on ADT + (No significant differences between arms at any time point)
Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer + (No significant differences between arms.)
Ota et al. (2014): The effect of pyridoxine for prevention of hand-foot-syndrome in colorectal cancer patients with adjuvant chemotherapy using capecitabine: A randomized study + (No significant differences between interve … No significant differences between intervention group and control group Number (%):Hematologic side effects:Leukopenia: intervention: 10 (33.3), control: 10 (33.3), not significant Thrombocytopenia: intervention: 4 (13.3), control: 4 (13.3), not significant Hyperbilirubinemia: intervention: 4 (13.3), control: 2 (6.7), not significant AST/ALT elevation: intervention: 4 (13.3), control: 6 (20), not significant Grade 3 onlyHematologic side effects:Intervention: n = 1 (thrombocytopenia), control: n = 1 (leukopenia)Non-hematologic side effects: Nausea: intervention: 10 (33.3), control: 5 (13.3%), not significant Stomatitis: intervention: 4 (13.3), control: 4 (13.3), not significant Diarrhea: intervention: 2 (6.7), control: 2 (6.7), not significant Peripheral neuropathy: intervention: 1 (3.3%), control: 1 (3.3%), not significant(3.3%), control: 1 (3.3%), not significant)
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (No significant differences between the arms, majority of patients did not report episodes of vomiting (mean incidence = 0.5))
Rastelli et al. (2011): Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial + (No significant differences between the arms)
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (No significant differences between the arms.)
Ribeiro et al. (2017): Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer + (No significant differences between the groups over the 4 cycles)
Ribeiro et al. (2017): Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer + (No significant differences between the groups over the 4 cycles)
Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (No significant differences between the treatment arms (from day 0 until day 21); no p-value reported)
Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial + (No significant differences in VAS scores; No significant differences in doses of analgesic medication consumption)
Khodabakhshi et al. (2019): Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study + (No significant differences in body weight, BMI, fat (%) between intervention arm compared to comparison arm (p>0.05, p>0.05, p>0.05) after 9 weeks)
Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…) + (No significant differences in frequencies … No significant differences in frequencies between arms for common adverse events, e.g. nausea/vomiting, fatigue, pain, anemia, dizziness, dyspnea, diarrhea, obstipation, vertigo (all p's ≥ .42) No differences for CannTox scales dizziness, feeling good, feeling high, hallucinations, palpitations, panic attacks, feeling active or unsteady walkingSee Arms/Side effects for detailed descriptionArms/Side effects for detailed description)
Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (No significant differences in median durat … No significant differences in median duration of PSA progression-free survival;median duration of tumor progression-free survival and median duration of clinical progression-free survival could not be reliably assessed due to the lack of regularly scheduled tumor imaging lack of regularly scheduled tumor imaging)