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- Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (Intervention-associated events in n=106 (6 … Intervention-associated events in n=106 (60%): drowsiness, dizziness, nausea, confusion, vomiting, hypotension, hypercalcemia, increased gamma GT</br></br></br>Most side effects were mild/moderate; no statistical comparisons given; one case of syncope probably related to THC; other events not associated with interventioner events not associated with intervention)