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- Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial + (NI)
- Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial + (NI)
- Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (NI)
- Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (NI)
- Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (NI)
- Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (NI)
- Mondal et al. (2014): Comparative study among glutamine, acetyl-L-carnitine, vitamin-E and methylcobalamine for treatment of paclitaxel-induced peripheral neuropathy + (NI)
- Mondal et al. (2014): Comparative study among glutamine, acetyl-L-carnitine, vitamin-E and methylcobalamine for treatment of paclitaxel-induced peripheral neuropathy + (NI)
- Mondal et al. (2014): Comparative study among glutamine, acetyl-L-carnitine, vitamin-E and methylcobalamine for treatment of paclitaxel-induced peripheral neuropathy + (NI)
- Mondal et al. (2014): Comparative study among glutamine, acetyl-L-carnitine, vitamin-E and methylcobalamine for treatment of paclitaxel-induced peripheral neuropathy + (NI)
- Cohen et al. (2018): Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial + (NI Weight loss unclear)
- Cohen et al. (2018): Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial + (NI Weight loss unclear)
- Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients + (Nausea and vomiting: n=14; Weight loss: n=1; Peripheral neuropathy: n=5; Bone Marrow depression: n=2; Any other hematologic, renal and digestive complication: n=21)
- Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients + (Nausea and vomiting: n=8; Weight loss: n= … Nausea and vomiting: n=8; </br>Weight loss: n=1; </br>Peripheral neuropathy: n=3; </br>Bone Marrow depression: n=2; </br>Transient Cortical Blindness: n=1; </br>Any other hematologic, renal and digestive complication: n=10</br></br>No side effects were reported regarding the ginger intervention.eported regarding the ginger intervention.)
- Sangthawan et al. (2013): A randomized double-blind, placebo-controlled trial of zinc sulfate supplementation for alleviation of radiation-induced oral mucositis and pharyngitis in head and neck cancer patients + (Nausea, vomiting)
- Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial + (No adverse events attributed to vitamin D3)
- Hodgson et al. (2012): Reflexology versus Swedish Massage to Reduce Physiologic Stress and Pain and Improve Mood in Nursing Home Residents with Cancer: A Pilot Trial. + (No adverse events were observed.)
- Hodgson et al. (2012): Reflexology versus Swedish Massage to Reduce Physiologic Stress and Pain and Improve Mood in Nursing Home Residents with Cancer: A Pilot Trial. + (No adverse events were observed.)
- Sahebnasagh et al. (2017): Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial + (No adverse events were reported by the patients)
- Puataweepong et. al (2009): The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: a double-blind placebo-controlled study + (No adverse events were reported by the patients.)
- Sahebnasagh et al. (2017): Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial + (No adverse events were reported by the patients.)
- Dardano et al. (2012): The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with Iodine-131 + (No clinically relevant side effects.)
- Dardano et al. (2012): The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with Iodine-131 + (No clinically relevant side effects.)
- Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (No differences for sleepiness (p=0.32), anxiety (p=0.92) and xerostomia (p=0.83))
- Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (No differences for sleepiness (p=0.32), anxiety (p=0.92) and xerostomia (p=0.83))
- Ansari et al. (2016): Efficacy of Ginger in Control of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients Receiving Doxorubicin- Based Chemotherapy + (No ginger related side effects were reported.)
- Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia + (No grade 4 or grade 5 adverse events, n=1 renal stones, 4 grade 3 events (deemed to be unrelated to the study drugs))
- Niravath et al. (2019): Randomized controlled trial of high‐dose versus standard‐dose vitamin D3 for prevention of aromatase inhibitor‐induced arthralgia + (No grade 4 or grade 5 adverse events, n=1 hypercalcemia, 8 grade 3 events (deemed to be unrelated to the study drugs))
- Cruciani et al. (2012): L-Carnitine Supplementation for the Management of Fatigue in Patients With Cancer: An Eastern Cooperative Oncology Group Phase III, Randomized, Double-Blind, Placebo-Controlled Trial + (No group differences between side effect g … No group differences between side effect grade 5 (Fisher's exact p=0.64)</br></br>One death possibly caused by treatment (arm unclear). </br></br>Otherwise possibly/probably/definitely treatment related:</br>Hemoglobin: 10x, Fatigue: 2x, Itching: 1x, Rash: 1x, Constipation: 1x, Diarrhea: 1x, Dizziness: 4x, Vomiting: 1x, Infection reason unknown: 1x, Genitourinary tract: 1x, Abdominal pain: 1x, Dyspnea: 2x</br></br>By “treatment associated”, probably chemo-/radiotherapy meant. However, description not clear.apy meant. However, description not clear.)
- Cruciani et al. (2012): L-Carnitine Supplementation for the Management of Fatigue in Patients With Cancer: An Eastern Cooperative Oncology Group Phase III, Randomized, Double-Blind, Placebo-Controlled Trial + (No group differences between side effect g … No group differences between side effect grade 5 (Fisher's exact p=0.64)</br></br>One death possibly caused by treatment (arm unclear). </br></br>Otherwise possibly/probably/definitely treatment related:</br>Hemoglobin: 9x, Platelets: 2x, Death due to disease progression: 2x, Anorexia: 1x, Diarrhea: 4x, Dizziness: 4x, Vomiting: 2x, Abdominal pain: 2x, Atrial fibrillation: 1x, Stench: 1x, Extrapyramidal symptoms: 1x</br></br>By “treatment associated”, probably chemo-/radiotherapy meant. However, description not clear.apy meant. However, description not clear.)
- Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (No increase in toxicity was seen with the addition of DN-101 to docetaxel)
- Dörr et al. (2007): Efficacy of Wobe-Mugos E for Reduction of Oral Mucositis after Radiotherapy + (No interaction or side effect differences between arms: Skin erythema (p=0.15); dryness (p=0.33); moist skin peeling (p=0.57); pain on swallowing (p=0.96), degree of swallowing discomfort (p=0.53), analgesics needed (p=0.28))
- Dörr et al. (2007): Efficacy of Wobe-Mugos E for Reduction of Oral Mucositis after Radiotherapy + (No interaction or side effect differences between arms: Skin erythema (p=0.15); dryness (p=0.33); moist skin peeling (p=0.57); pain on swallowing (p=0.96), degree of swallowing discomfort (p=0.53), analgesics needed (p=0.28))
- Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study + (No patient reported any side-effect and there was no adverse event regardless of the odour score)
- Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study + (No patient reported any side-effect and there was no adverse event regardless of the odour score)
- Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms + (No patients reported adverse effects, and none withdrew from the study because of side effects.)
- Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms + (No patients reported adverse effects, and none withdrew from the study because of side effects.)
- Ertekin et al. (2004): Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study + (No serious side effects)
- Johansson et al. (2021): Vitamin D Supplementation and Disease-Free Survival in Stage II Melanoma: A Randomized Placebo Controlled Trial + (No severe adverse events: 7% grade 1–2 adverse events, no grade 3–4 events)
- Johansson et al. (2021): Vitamin D Supplementation and Disease-Free Survival in Stage II Melanoma: A Randomized Placebo Controlled Trial + (No severe adverse events: 7% grade 1–2 adverse events, no grade 3–4 events, neither of the events were linked to 25OHD serum levels)
- Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study + (No side effects)
- Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study + (No side effects)
- Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (No side effects)
- Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (No side effects)
- Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (No side effects)
- Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (No side effects)
- Lin et al. (2010): Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: subgroup analysis of a double-blind, randomized study + (No side effects)
- Lin et al. (2010): Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: subgroup analysis of a double-blind, randomized study + (No side effects)
- Moslemi et al. (2014): Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial + (No side effects)
- Najafizade et al. (2013): Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: A randomized placebo-controlled trial + (No side effects)
- Najafizade et al. (2013): Preventive effects of zinc sulfate on taste alterations in patients under irradiation for head and neck cancers: A randomized placebo-controlled trial + (No side effects)