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- Gujral et al. (2001): Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers + (Pain, fever, weakness, vomiting, itching, … Pain, fever, weakness, vomiting, itching, swelling, haemoptysis; no difference between the arms (p=kA)</br></br>Radiation therapy gaps: </br>3 gaps because of social/technical problems; in 2 patients in the control-arm, radiation had to be temporarily discontinued due to severe radiation therapy-related reactionssevere radiation therapy-related reactions)