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- Van Zandwijk et al. (2000): EUROSCAN, a Randomized Trial of Vitamin A and N-Acetylcysteine in Patients With Head and Neck Cancer or Lung Cancer + (Typical: mucocutaneous side effects (dryne … Typical: mucocutaneous side effects (dryness, desquamation, itching, bleeding, hair loss)</br></br>Severe side effects (grade 3/4)</br>- Gastrointestinal: 32 </br>- Skin: 50 </br>- Malaise: 5 </br>- Temporary increase in liver enzymes: 2</br>- Hypercholesterolemia: 2</br>- Bone pain: 2</br>- Other: 15lesterolemia: 2 - Bone pain: 2 - Other: 15)