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- Wrbka et al. (1987): Unterstützung der Chemotherapie inoperabler Karzinome durch proteolytische Fermente + (Treatment with Wobe Mugos E: Tolerance of … Treatment with Wobe Mugos E: </br>Tolerance of microclysms (67 patients in the evaluation): 87.3% of patients with good tolerance, 4 patients with sphincter weakness and limited ability to administer, 12.7% of patients with discontinuation due to gastrointestinal side effects</br></br>Tolerance of dragées (58 patients in the evaluation): 71.4% of patients with good tolerance, 28.6% of patients with discontinuation; in 27% of patients, intake could not be assessed due to unauthorised discontinuation or incorrect information</br></br>Tolerance of local intrapleural application (33 patients in the evaluation): 96.9% of patients with good tolerance, 3.1% of patients with discontinuationnce, 3.1% of patients with discontinuation)
- Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial + (Two patients (15.4%) in the aloe arm experienced nausea.)
- Van Zandwijk et al. (2000): EUROSCAN, a Randomized Trial of Vitamin A and N-Acetylcysteine in Patients With Head and Neck Cancer or Lung Cancer + (Typical: mucocutaneous side effects (dryne … Typical: mucocutaneous side effects (dryness, desquamation, itching, bleeding, hair loss)</br></br>Severe side effects (grade 3/4)</br>- Gastrointestinal: 32 </br>- Skin: 50 </br>- Malaise: 5 </br>- Temporary increase in liver enzymes: 2</br>- Hypercholesterolemia: 2</br>- Bone pain: 2</br>- Other: 15lesterolemia: 2 - Bone pain: 2 - Other: 15)
- Van Zandwijk et al. (2000): EUROSCAN, a Randomized Trial of Vitamin A and N-Acetylcysteine in Patients With Head and Neck Cancer or Lung Cancer + (Typical: mucocutaneous side effects (dryne … Typical: mucocutaneous side effects (dryness, desquamation, itching, bleeding, hair loss), symptoms of the digestive tract (especially dyspepsia)</br></br>Severe side effects (grade 3/4)</br>- Gastrointestinal: 47</br>- Skin: 43</br>- Malaise: 1</br>- Temporary increase in liver enzymes: 3</br>- Hypercholesterolemia 3</br>- Bone pain 2</br>- Other: 8cholesterolemia 3 - Bone pain 2 - Other: 8)
- Van Zandwijk et al. (2000): EUROSCAN, a Randomized Trial of Vitamin A and N-Acetylcysteine in Patients With Head and Neck Cancer or Lung Cancer + (Typical: symptoms of the digestive tract (especially dyspepsia) Severe side effects (grade 3/4) - Gastrointestinal: 44 - Skin: 11 - Malaise: 2 - Temporary increase in liver enzymes: 1 - Other: 3)
- Karp et al. (2012): Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597 + (Unclear association, but in long-term follow-up: n=26 in intervention arm had a diabetes diagnosis)
- Karp et al. (2012): Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597 + (Unclear association, but in long-term follow-up: n=12 in placebo arm had a diabetes diagnosis)
- Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer + (Very mild dizziness or light-headedness on day-5 of aromatherapy treatment n= 1)
- Salihah et al. (2016): The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting + (Very mild dizziness or light-headedness on day-5 of aromatherapy treatment n= 1)
- Nasser et al. (2017): Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients + (Vitamin D was well tolerated by patients with no localized or systemic allergic reactions.)
- Nasser et al. (2017): Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients + (Vitamin D was well tolerated by patients with no localized or systemic allergic reactions.)
- Sangthawan et al. (2015): Effects of zinc sulfate supplementation on cell-mediated immune response in head and neck cancer patients treated with radiation therapy + (Vomiting)
- Sangthawan et al. (2015): Effects of zinc sulfate supplementation on cell-mediated immune response in head and neck cancer patients treated with radiation therapy + (Vomiting)
- Freedland et al. (2020): A Randomized Controlled Trial of a 6-month low carbohydrate intervention on disease progression in men with recurrent prostate cancer: Carbohydrate and Prostate Study 2 (CAPS2) + (Weight loss; moderate nausea; diarrhea, constipation, headache, fatigue, feeling of weakness (asthenia))
- Jyothirmayi et al. (1996): Efficacy of Vitamin A in the Prevention of Locoregional Recurrence and Second Primaries in Head and Neck Cancer + (dryness of the tongue (n=2), not a drop-out reason)
- Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial + (itching, burning and epidermal changes: 49,2 %)
- Jacot et al. (2016): Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study + (n=1 hypercalciuria)
- Jacot et al. (2016): Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study + (n=1 hypercalciuria)
- Frankling et al. (2021): ‘Palliative-D’ - Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial + (n=1 renal failure, n=2 mild hypercalcemia, n=1 gastrointestinal symptoms (mild diarrhea, nausea and abdominal pain), n=1 shortness of breath)
- Frankling et al. (2021): ‘Palliative-D’ - Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial + (n=2 mild hypercalcemia, n=2 gastrointestinal symptoms (mild diarrhea, nausea and abdominal pain), n=1 elevated creatine level)
- Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial + (n=3 fractures (1.3%), n=2 urinary stones (0.9%); no patients developed hypercalcemia during the follow-up period)
- Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial + (n=5 fractures (3.4%); no patients developed hypercalcemia during the follow-up period)