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- Mayne et al. (2001): Randomized Trial of Supplemental beta-Carotene to Prevent Second Head and Neck Cancer + (- Survival curves generated (Kaplan and Me … - Survival curves generated (Kaplan and Meier)</br>- Log-rank test used to compare survival distributions between the two groups</br>- Cox proportional hazards models used to calculate the RR (relative risk) of having an end point in the b-carotene group relative to those taking placebo, adjusted for other covariatesing placebo, adjusted for other covariates)