Property:Results after intervention
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Dale et al. (2001): Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects +
There were signifcantly (p<0.001) fewer urogenial symptoms (evaluted as maximum extent) in the enzyme-arm: enzyme-arm = 0.93 (0.52); placebo-arm = 1.38 (0.56). The treatment effect was observed from 1 week after start of radiation therapy until the last follow-up visit 5 month after intervention. +
Dardano et al. (2012): The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with Iodine-131 +
Significantly lower increase in Micronuclei in the Ginkgo arm (day 7: Mean=11.5, SD=2.4; day 90: Mean=2.9, SD=1.4) compared to placebo (day 7: Mean=17.1, SD=2.3; day 90: Mean=9.0, SD=1.3), p<0.01 +
Dardano et al. (2012): The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with Iodine-131 +
Significantly lower increase in "clastogenic" factors in the Ginkgo arm (day 7: Mean=5.0, SD=2.9; day 90: Mean=1.9, SD=0.9) compared to placebo (day 7: Mean=10.5, SD=2.1; day 90: Mean=5.5, SD=1.2), p<0.05 +
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study +
1 Patient: depression
1 Patient: dizziness +
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study +
No significant difference between the arms.
Comparison between the Placebo and Intervention Arm: After Day 42: p = .75 +
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study +
No significant difference between the arms.
Comparison between the Placebo and Intervention Arm: After Day 42: p = .81 +
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study +
No significant difference between the arms.
Comparison between the Placebo and Intervention Arm: After Day 42: HADS A: p = .75, HADS D: p = .94 +
Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis +
After 6 month, reduction in % (SD) in each case:
Pentoxyfillin + vitamin E: 39.1 (12.1), pentoxyfillin + placebo: 32.4 (20.8), vitamin E + placebo: 37.1 (15.5); placebos: 32.9 (18.5) +
Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis +
NA +
Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis +
After 6 month, reduction in % (SD) in each case:
Pentoxyfillin + vitamin E: 73.0 (7.2), pentoxyfillin + placebo: 48.6 (35.9), vitamin E + placebo: 52.8 (29.4); placebos: 50.8 (23.9) +
Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis +
NA +
Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis +
After 6 month, reduction in % (SD) in each case:
Pentoxyfillin + vitamin E: 60.2 (10.7), pentoxyfillin + placebo: 39.1 (37.4), vitamin E + placebo: 40.0 (32.0); placebos: 42.6 (17.4)
ANOVA: ns., trend of a signif. interaction with vitamin E +
Dias et al. (2015): The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study +
Overall:
Significantly lower DPOAEs in placebo arm compared to ginkgo arm at a frequency of 8KHz, p=0.03
Significantly lower SNRs in placebo arm compared to Ginkgo arm at a frequency of 8KHz, p=0.04 +
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life +
No significant difference between the 2 arms; no further information given +
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life +
No significant differences in disease-free survival between the placebo and guarana arm (p=0.363, only graphically displayed). +
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life +
No significant differences in overall survival between the placebo and guarana arm (p=0.498, only graphically displayed). +
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life +
No significant differences were observed between the placebo and guarana arms. +
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life +
FACT-HN35:
After first round of chemoradiotherapy: significant improvement in guarana group for domains pain (p = 0.0133), social eating (p = 0.0227), swallowing (p = 0.0254), coughing (p = 0.0107), and weight loss (p = 0.012)
After the fourth round of chemoradiotherapy: significantly worse in domain weight loss (p = 0.0074) and greater use of a nasogastric tube (p = 0.051), in addition to increased use of analgesics (p = 0.0253) in guarana group
FACT Questionnaire:
Comparison between intervention and placebo arm: trend toward worsening in the overall domain: p = .0054, significant worsening in the functional: p = .018 and symptoms domain: p = .0042 after the second cycle of chemotherapy; no significant differences, in any QOL domains, either for the guarana or placebo group, when the first measures were compared to the last assessments of each domain for each particular group
EORTC-QOL C30:
No improvement in symptoms in the three domains (functional, overall, and symptoms) in the guarana group compared to the placebo group
No further information or statistical values given, domain specific results of the EORTC questionnaire only displayed in a graphic +
Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population? +
Significant and clinically relevant improvement over time in both arms (reflexology: M= -0.70 [95% CI: -1.16, -0.24]; aromatherapy massage: M= -1.16 [95% CI: -1.15, -0.80]), but no sig. arm differences (M= 0.45 [95% CI: -0.12, 1.03]; p=NI). +
Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population? +
No significant difference between the arms (p= 0.408) +