Property:Dosage and regime
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C
Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer +
NI +
Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer +
Oral green tea extract with 800mg EGCG twice daily for 6 month +
Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer +
Oral green tea extract with 400mg EGCG twice daily for 6 month +
Cruciani et al. (2009): L-Carnitine Supplementation in Patients with Advanced Cancer and Carnitine Deficiency: A Double-Blind, Placebo-Controlled Study +
0.5 g/day for 2 days, then 1 g/day for 2 days, and then 2 g (2x1g) daily for 10 days in 10 ml syrup = 14 days + 14 days after unblinding +
Cruciani et al. (2009): L-Carnitine Supplementation in Patients with Advanced Cancer and Carnitine Deficiency: A Double-Blind, Placebo-Controlled Study +
14 days, then L-Carnitine 2g (2x 1g) daily for 14 days +
Cruciani et al. (2012): L-Carnitine Supplementation for the Management of Fatigue in Patients With Cancer: An Eastern Cooperative Oncology Group Phase III, Randomized, Double-Blind, Placebo-Controlled Trial +
2g (2x 1g) daily oral
Duration: 8 weeks +
Cruciani et al. (2012): L-Carnitine Supplementation for the Management of Fatigue in Patients With Cancer: An Eastern Cooperative Oncology Group Phase III, Randomized, Double-Blind, Placebo-Controlled Trial +
L-carnitine was a standardized commercial preparation of 10 g of levocarnitine inert salt in 100-mL solution
2g (2x 1g) daily oral
Duration: 8 weeks +
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial +
Placebo tablets
* once a day before radiotherapy in the first week
* twice a day in the second week
* third week until end of radiotherapy: adjusted by radiation oncologist up to maximal 4 tablets +
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial +
0.5 mg nabilone tablets (from Valeant Canada)
* once a day before radiotherapy in the first week
* twice a day in the second week
* third week until end of radiotherapy: adjusted by radiation oncologist up to maximal 4 tablets +
D
Da Costa et al. (2009): Effectiveness of Guarana (Paullinia cupana) for Postradiation Fatigue and Depression Results of a Pilot Double-Blind Randomized Study +
Daily for 14 days
Cross-over: 14 days of placebo +
Da Costa et al. (2009): Effectiveness of Guarana (Paullinia cupana) for Postradiation Fatigue and Depression Results of a Pilot Double-Blind Randomized Study +
Daily for 14 days
Cross-over: 75 mg of guayana extract daily for 14 days +
Dale et al. (2001): Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects +
Daily 4x3 tablets of WOBE-MUGOS E (10mg papain, 40mg trypsin, 40mg chymotrypsin), starting 8(+/-1) days before the first radiotherapy session over a period of 69(+/-15) days.
+ all patients received 50-60 Gy of external beam radiation in 20-30 fractions for 35(+/-6) days , followed by intra-cavitary brachytherapy at a dose of 20–30 Gy using a BARC applicator. +
Dale et al. (2001): Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects +
Control arm patients did not receive any additional treatment
+ all patients received 50-60 Gy of external beam radiation in 20-30 fractions for 35(+/-1) days, followed by intra-cavitary rachytherapy at a dose of 20–30 Gy using a BARC applicator. +
Dardano et al. (2012): The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with Iodine-131 +
120mg/daily
Duration: 3 days prior to radioiodine treatment until 30 days after
+ Radioiodine therapy (Iodine -131 therapy): after 30 days without levothyroxine, all patients received a dose of 3.7 GBq (100mCi) +
Dardano et al. (2012): The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with Iodine-131 +
120mg/daily
Duration: 3 days prior to radioiodine treatment until 30 days after
+ Radioiodine therapy (Iodine -131 therapy): after 30 days without levothyroxine, all patients received a dose of 3.7 GBq (100mCi) +
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study +
37.5 mg by mouth, 2x/day
Starting after 1 week of chemotherapy, for 3 weeks
Depending on the improvement or stabilization of the BFI scores: randomized assignment to either the continuation of PC-18 at the same dose +
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study +
37.5 mg by mouth, 2x/day
Starting after 1 week of chemotherapy, for 3 weeks
Depending on the improvement or stabilization of the BFI scores: randomized assignment to a placebo for another 3 weeks +
Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis +
oral, 2x Placebo + 1000 U daily Vitamin E (2x 500 U)
Start: +7 (± 4) years post-RTX
Duration: 6 months +
Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis +
oral, 800 mg daily Pentoxifyllin (2x 400 mg) + 1000 U daily Vitamin E (2x 500 U)
Start: +7 (± 4) years post-RTX
Duration: 6 months +
Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis +
oral, 800 mg daily Pentoxifyllin (2x 400 mg) + 2x placebo
Start: +7 (± 4) years post-RTX
Duration: 6 months +