Property:Dosage and regime
This is a property of type Text.
D
Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis +
oral, 4x Placebo
Start: +7 (± 4) years post-RTX
Duration: 6 months +
Dias et al. (2015): The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study +
Capsules, 120 mg 2x/day
Duration: throughout cisplatin therapy according to the respective protocol for the tumor (cumulative doses ranged from 50 to 300mg/m<sup>2</sup>). +
Dias et al. (2015): The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study +
Capsules, 120 mg 2x/day
Duration: throughout cisplatin therapy according to the respective protocol for the tumor (cumulative doses ranged from 50 to 300mg/m<sup>2</sup>). +
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life +
2 daily doses before meals,
During 6 weeks of chemotherapy +
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life +
2 daily doses before meals, 100 mg, , D160314, with 7.4% caffeine content, manufactured by PharmaNostra
During 6 weeks of chemotherapy +
Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population? +
4 sessions, no information regarding duration of therapy +
Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population? +
4 sessions for 1 h each, spread over an average of 10 weeks +
3x4 tablets of placebo daily, starting 3 days before the first radiotherapy dose until 5 days after the last dose of radiotherapy
The placebo tablets were looking identical and contained ludipress, corn starch, magnesium stearate, cellulose, mikri, silicic acid, Capol 600, saccharose, talcum, vanilline, calcium carbonate, titanium dioxide, soluble polyvinylpyrrolidone, white clay, Pek 6000, isopropanol, Eudragit L 12,5 P.
+ all participants: Radiotherapy protocols comprised conventional fractionation with 1.8–2.0 Gy/fraction, 5× per week to total doses of 60–66 Gy per 6–7 weeks, or hyperfractionation with 2 × 1.2 Gy per day, 5× per week to a total dose of 72 Gy per 6–7 weeks.
Hyperfractionation was applied in 11 (33%) patients in the placebo arm. +
3x4 tablets of WOBE-MUGOS E daily, starting 3 days before the first radiotherapy dose until 5 days after the last dose of radiotherapy.
The verum (Wobe-Mugos E) contained papain 100 mg, trypsin 40 mg, and chymotrypsin 40 mg.
+ all participants: Radiotherapy protocols comprised conventional fractionation with 1.8–2.0 Gy/fraction, 5× per week to total doses of 60–66 Gy per 6–7 weeks, or hyperfractionation with 2 × 1.2 Gy per day, 5× per week to a total dose of 72 Gy per 6–7 weeks.
Hyperfractionation was applied in 8 (22%) patients in the Wobe-Mugos E arm +
E
Ehrenpreis et al. (2005): A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial of Retinol Palmitate (Vitamin A) for Symptomatic Chronic Radiation Proctopathy +
10,000 IU orally 2 times a day +
Ehrenpreis et al. (2005): A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial of Retinol Palmitate (Vitamin A) for Symptomatic Chronic Radiation Proctopathy +
Placebo capsules orally 2 times a day +
Emami et al. (2014): Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of green tea in preventing acute gastrointestinal complications due to radiotherapy +
One green tea tablet (450 mg Camgreen) daily for 5 weeks during radiation +
Emami et al. (2014): Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of green tea in preventing acute gastrointestinal complications due to radiotherapy +
One placebo tablet daily for 5 weeks during radiation +
Ertekin et al. (2004): Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study +
Three times daily at 8-hour intervals, capsules containing 50 mg zinc (Zinco 220 capsule),
Duration was from first day of radiotherapy, during radiotherapy and for 6 weeks after treatment (including weekends and other times when interruption of radiotherapy was necessary) +
Ertekin et al. (2004): Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: a prospective, placebo-controlled, randomized study +
Three times daily at 8-hour intervals, empty capsules bought from the same medicine firm to be identical to the zinc sulfate capsules,
Duration was from first day of radiotherapy, during radiotherapy and for 6 weeks after treatment (including weekends and other times when interruption of radiotherapy was necessary) +
F
Fahimi et al. (2011): Evaluating the Effect of Zingiber Officinalis on Nausea and Vomiting in Patients Receiving Cisplatin Based Regimens +
Four capsules of powdered ginger (Zintoma®, Gol Daru) daily (each capsule contained 250 mg of ginger) +
Fahimi et al. (2011): Evaluating the Effect of Zingiber Officinalis on Nausea and Vomiting in Patients Receiving Cisplatin Based Regimens +
Four capsules of placebo (lactose) +
Fallahi et al. (2013): Does vitamin E protect salivary glands from I-131 radiation damage in patients with thyroid cancer? +
Oral, 800 IU per day
Start: Week -1 radioiodine therapy to 4 weeks after
Duration: 5 weeks +
Fallahi et al. (2013): Does vitamin E protect salivary glands from I-131 radiation damage in patients with thyroid cancer? +
Daily
Start: Week -1 radioiodine therapy to 4 weeks after
Duration: 5 weeks +
Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies +
Sativex® (Nabiximol, THC 27 mg/mL, CBD 25 mg/mL) via oral spray (self-applied by patient)
* week 1: dose finding; week 2-5: stable dose, max. 10 sprays
* first week mean number of sprays: 3.7, stabilized over 4 weeks (6.3 sprays per day) +