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List of results

Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial + (At entry 88% of patients in the placebo and 92% of patients in the L-Carnitine group received chemotherapy.)
Raoufinejad et al. (2019): Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial + (Autologous peripheral blood hematopoietic stem cell transplantation)
Stendell-Hollis et al. (2010): Green tea improves metabolic biomarkers, not weight or body composition: a pilot study in overweight breast cancer survivors + (Breast cancer survivors; completed primary … Breast cancer survivors; completed primary treatment(s) for invasive, early stage breast cancer at least 12 months prior and no more than 10 years prior; received chemotherapy (neo-adjuvant or adjuvant with any medically-prescribed agent/regime) for treatmentlly-prescribed agent/regime) for treatment)
Ribeiro et al. (2017): Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer + (CAPOX (capecitabine + oxaliplatin) schedule; capecitabine; 5-fluorouracil and folinic acid)
Uthaipaisanwong et al. (2020): Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study + (Carboplatin-paclitaxel chemotherapy Types of chemotherapy, n (%) neoadjuvant: 4 (8.5), adjuvant: 43 (91.5))
Hoopfer et al. (2015): Three-arm randomized phase III trial: Quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy + (Chemotherapy before radiotherapy per arm … Chemotherapy before radiotherapy per armPowder arm: No = 47 (59.5%); Yes = 32 (40.5%)Aloe arm: No = 31 (38.3%); Yes = 50 (61.7%)Placebo arm: No = 36 (46.8%); Yes = 41 (53.3%)Surgery per arm: Powder arm: Mastectomy = 32 (40.5%); Segmental resection = 47 (59.5%)Aloe arm: Mastectomy = 34 (42%); Segmental resection = 47 (58%)Placebo arm: Mastectomy = 23 (29.9%); Segmental resection = 54 (70.1%) (29.9%); Segmental resection = 54 (70.1%))
Wyatt et al. (2017): A Randomized Clinical Trial of Caregiver-Delivered Reflexology for Symptom Management During Breast Cancer Treatment + (Chemotherapy or specific cancer therapy: 210 patients, hormone therapy only: 46 patients.)
Strasser et al. (2006): Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled (…) + (Chemotherapy patients (received chemotherapy in the 4 weeks before baseline and who intended to continue chemotherapy during the study), per arm: THC = 52% Cannabis extract = 47% Placebo = 52%)
Heggie et al. (2002): A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue + (Chemotherapy per arm (n): Aloe vera arm: yes = 24; no = 83 Placebo arm: yes = 24; no = 77)
Braga et al. (2015): Effect of Zinc Supplementation on Serological Response to Vaccination Against Streptococcus Pneumoniae in Patients Undergoing Chemotherapy for Colorectal Cancer + (Chemotherapy regimen: CAPOX (capecitabine + oxaliplatin), Capecitabine or 5-fluorouracil + folinic acid)
Ansari et al. (2016): Efficacy of Ginger in Control of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients Receiving Doxorubicin- Based Chemotherapy + (Chemotherapy regimens (n intervention vs. … Chemotherapy regimens (n intervention vs. placebo arm):- AC, i.e. doxorubicin60 mg/m2 +cyclophosphamid 600 mg/m2 (41 vs. 44)- CAF, i.e. cyclophosphamide 500mg/m2 + doxorubicin 50mg/ m2 + 5-Fluorouracil 500mg/m2 (19 vs. 18)- TAC, i.e. docetaxel 75mg/m2 + doxorubicin 50mg/m2 + cyclophosphamide 500mg/m2 (15 vs. 13)up> + doxorubicin 50mg/m2 + cyclophosphamide 500mg/m2 (15 vs. 13))
Arbabi-kalati et al. (2012): Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: A double-blind randomized clinical trial + (Chemotherapy treatment by a regimen including cyclophosphamide, doxorubicin, dacarbazine, gemcitabine, methotrexate, and 5-fluorouracil)
Arslan et al. (2015): Oral Intake of Ginger for Chemotherapy-Induced Nausea and Vomiting Among Women With Breast Cancer + (Chemotherapy with adjuvant anthracycline (chemotherapy protocols: anthracycline, cyclophosphamide, doxorubicin, and 5-ﬂuorouracil), no significant differences between arms in chemotherapy characteristics (p > 0.05))
Braik et al. (2014): Randomized trial of vitamin B6 for preventing hand-foot syndrome from capecitabine chemotherapy + (Chemotherapy with capecitabine Capecitabine alone (n = 43) Capecitabine + oxaliplatin (n = 24) Capecitabine + lapatinib (n = 5) Capecitabine + trastuzumab (n = 3) Capecitabine + cetuximab (n = 2))
Olsen et al. (2001): The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy + (Chemotherapy: Aloe arm: Yes = 28%, No = 72% Control arm: Yes = 26%, No = 74% Cumulative dose was dichotomized into ≤2,700 cGy or >2,700 cGy.)
Lissoni et al. (2009): A Randomized Study of Chemotherapy versus Biochemotherapy with Chemotherapy plus Aloe arborescens in Patients with Metastatic Cancer + (Chemotherapy: Non-small cell lung cancer … Chemotherapy: Non-small cell lung cancer: Chemotherapy consisted of cisplatin (CDDP) plus etoposide (VP16) or weekly vinorelbine (VNR)Small cell lung cancer: Chemotherapy consisted of cisplatin (CDDP) plus etoposide (VP16)Colorectal cancer: low-dose oxaliplatin (OXA) plus 5-fluorouracil (5-FU)Gastric cancer: weekly 5-fluorouracil Pancreatic adenocarcinoma: weekly gemcitabine (GEM)c adenocarcinoma: weekly gemcitabine (GEM))
Stephenson et al. (2017): Partner-delivered reflexology: Effects on cancer pain and anxiety. + (Chemptherapy/Radiation therapy/OP (at least 6 weeks before or after surgery))
Dias et al. (2015): The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study + (Cisplatin)
Fahimi et al. (2011): Evaluating the Effect of Zingiber Officinalis on Nausea and Vomiting in Patients Receiving Cisplatin Based Regimens + (Cisplatin chemotherapy regimens, n (%) * … Cisplatin chemotherapy regimens, n (%) * Cisplatin + Etoposide 7 (19%)* Cisplatin + Gemcitabine 7 (19%)* Cisplatin + Docetaxel 11 (31%)* Cisplatin + Vinorelbine 4 (11%)* Cisplatin + Cyclophosphamide + Doxorubicin 4 (11%)* Cisplatin + Paclitaxel + Doxorubicin 1 (3%)* Cisplatin + 5-FU + Docetaxel 1 (3%)* Cisplatin + Pemetrexed 1 (3%)el 1 (3%) * Cisplatin + Pemetrexed 1 (3%))

Argyriou et al. (2006): A randomized controlled trial evaluating the efficacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: final results + (Cisplatin-based chemotherapy)

Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial + (Cisplatin-based chemotherapy (few patients with carboplatin or oxaliplatin))
Pace et al. (2010): Vitamin E neuroprotection for cisplatin neuropathy + (Cisplatin-based chemotherapy, cisplatin was administered in combination regimens on the basis of the specific tumor site)
Pace et al. (2003): Neuroprotective Effect of Vitamin E Supplementation in Patient Treated With Cisplatin Chemotherapy + (Cisplatin-based chemotherapy; Cisplatin w … Cisplatin-based chemotherapy;Cisplatin was administered in combination regimens based on the specific tumor site as follows: Lung and urethral cancer:cisplatin 75 mg/m² on day 1 and gemcitabine 1,000 mg/m² on day 1 and day 8 every 3 weeks; ovarian cancer: cisplatin 75 mg/m² and endoxan 600 mg/m² on day 1 every 3 weeks; head and neck cancer: cisplatin 100 mg/m² on day 1 and fluorouracil 1,000 mg/m² on day 1 to 4 every 3 to 4 weeks; ethmoidal cancer: cisplatin 25 mg/m² and etoposide 80 mg/m² on day 1 to 3 every 3 weeks; gastric cancer: PELF regimen (cisplatin 40 mg/m² and epirubicin 30 mg/m² on days 1 and 5 plus fluorouracil 300 mg/m² and folinic acid 100 mg/m² on days 1 to 4 every 3 weeks); testicular cancer: PEB regimen (cisplatin 20 mg/m² and etoposide 100 mg/m² on days 1 to 5 plus bleomycin 30 mg on days 2, 9, and 16 every 3 weeks) 30 mg on days 2, 9, and 16 every 3 weeks))
Mahmoodnia et al. (2017): Ameliorative effect of lycopene effect on cisplatin-induced nephropathy in patients + (Cisplatin-chemotherapy)
Villani et al. (2016): Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial + (Cisplatin-chemotherapy)
Asfour et al. (2006): Effect of high-dose sodium selenite therapy on polymorphonuclear leukocyte apoptosis in non-Hodgkin's lymphoma patients + (Combination chemotherapy composed of cyclo … Combination chemotherapy composed of cyclophosphamide doxorubicin, oncovine, and prednisone (CHOP), treatment consisted of sisted of 750 mg/m2 on first day of the treatment cycle intravenously (IV) cyclophosphamide, 50 mg/m2 IV doxorubicin, 1.4 mg/m2 IV vincristine, and 100 mg po days 1 to 5 prednisone; chemotherapy cycles were repeated every 28 daystherapy cycles were repeated every 28 days)
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (Concomitant antineoplastic palliative chemotherapy in 77.1-81.8% of patients per arm, NI on percentage of patients receiving hormone therapy)
Puri et al. (2010): Lycopene in treatment of high-grade gliomas: A pilot study + (Concurrent chemotherapy with paclitaxel at a dose of 60 mg/m2i/v weekly)
Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial + (Continuous infusion of 2400 mg/m … Continuous infusion of 2400 mg/m2 of 5-fluorouracil (5-FU) over 46 to 48 hours, a bolus of 400 mg/m2 of 5-FU, 400 mg/m2 of leucovorin, and 85 mg/m2 of oxaliplatin (mFOLFOX6) plus 5 mg/kg of bevacizumab administered intravenously every 14 days per institutional standard of care (1 cycle=14 days), bevacizumab was allowed to be omitted during the first cycle and started with cycle 2 at the investigator’s discretione omitted during the first cycle and started with cycle 2 at the investigator’s discretion)
Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial + (Continuous infusion of 2400 mg/m … Continuous infusion of 2400 mg/m2 of 5-fluorouracil (5-FU) over 46 to 48 hours, a bolus of 400 mg/m2 of 5-FU, 400 mg/m2 of leucovorin, and 85 mg/m2 of oxaliplatin (mFOLFOX6) plus 5 mg/kg of bevacizumab administered intravenously every 14 days per institutional standard of care (1 cycle=14 days), bevacizumab was allowed to be omitted during the first cycle and started with cycle 2 at the investigator’s discretione omitted during the first cycle and started with cycle 2 at the investigator’s discretion)
Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial + (Curative surgery per arm for: 23 carcinom … Curative surgery per arm for:23 carcinomas of the rectosigmoid(enzyme arm: 9; placebo arm: 14)17 endometrial carcinoma (enzyme arm: 8; placebo arm: 9) 14 uterine cervix cancer (enzyme arm: 11; placebo arm: 3), 1 carcinoma of the vulva (enzyme arm: 0; placebo arm: 1)1 prostate cancer (enzyme arm: 0; placebo arm: 1)e cancer (enzyme arm: 0; placebo arm: 1))
Newling et al. (1995): Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group + (Cystoscopy and resection/fulguration of all recurrences were performed every 3 months during the first year and every 6 months thereafter.)
Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (Daily fraction was 180 cGy to 200 cGy in f … Daily fraction was 180 cGy to 200 cGy in five weekly fractions,total dose prescribed was 7,000 cGy;No significant difference in the radiation dose, fraction, and duration was identified between intervention and placebo arm; all patients received concomitant chemotherapy with 5-fluorouracil and cis-platinumerapy with 5-fluorouracil and cis-platinum)
Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer + (Docetaxel was supplied commercially. Patients received, on a 28-day cycle, 35 mg/m2 docetaxel i.v. on days 1, 8, and 15 over 1 hour)
Ota et al. (2014): The effect of pyridoxine for prevention of hand-foot-syndrome in colorectal cancer patients with adjuvant chemotherapy using capecitabine: A randomized study + (Eight 3-week cycles of 2,500 mg/m2 of capecitabine per day in two divided doses for 14 days, followed by a 7-day rest period)
Jeon et al. (2016): Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial + (Elective laparoscopic colectomy)
Hejazi et al. (2013): A pilot clinical trial of radioprotective effects of curcumin supplementation in patients with prostate cancer + (External beam radiotherapy (EBRT), in combination with hormone ablation)
Hejazi et al. (2016): Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study + (External beam radiotherapy (EBRT), in combination with hormone ablation)
Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation + (External beam radiotherapy: LINAC or Cobal … External beam radiotherapy: LINAC or Cobalt-10, total mean radiation dose (SD): 62.3 (9.13), radiotherapy duration (wks) (SD): 7.38 (1.28);daily fractions of 180– 200 cGy lasting from 5 to 9 weeks, for a total dose of 45-70 Gy, the radiation fields were the same for all patients, and the tongue was always includedtients, and the tongue was always included)
Muecke et al. (2010): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology + (External radiotherapy was delivered with a … External radiotherapy was delivered with a 6- to 18-MV linear accelerator. Five fractions per week were planned. Treatment was given with a three- to four-field box technique. Radiotherapy was given as three-dimensional conformal radiotherapy. Computed tomography–based treatment planning was performed in all cases. The clinical target volume encompassed the primary tumor region and the pelvic regional lymph nodes. High-dose rate brachytherapy of the vagina was considered optional in accordance with German evidence-based guidelines. Brachytherapy was delivered by iridium 192 afterloading.was delivered by iridium 192 afterloading.)
Muecke et al. (2013): Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology-a subgroup analysis of a multicenter, phase III trial + (External radiotherapy was delivered with a … External radiotherapy was delivered with a 6- to 18-MV linear accelerator. Five fractions per week were planned. Treatment was given with a three- to four-field box technique. Radiotherapy was given as three-dimensional conformal radiotherapy. Computed tomography–based treatment planning was performed in all cases. The clinical target volume encompassed the primary tumor region and the pelvic regional lymph nodes. High-dose rate brachytherapy of the vagina was considered optional in accordance with German evidence-based guidelines. Brachytherapy was delivered by iridium 192 afterloading.was delivered by iridium 192 afterloading.)
Özdelikara et al. (2017): The Effect of Reflexology on Chemotherapy-induced Nausea, Vomiting, and Fatigue in Breast Cancer Patients + (First chemotherapy cycle between April 2011 and October 2013)
Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study + (First cycle of AC chemotherapy)
Jacot et al. (2016): Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study + (Fluorouracil 500 mg/m2</sup& … Fluorouracil 500 mg/m2 , epirubicin 100 mg/m2 and cyclophosphamide 500 mg/m2 (FEC) i.v. on day 1 every 21 days for three cycles, followed by docetaxel 100 mg/m2 i.v. on day 1 every 21 days for three cycles;Docetaxel - 2 cyclophosphamide, methotrexate, 5-fluorouracile;Trastuzumabes; Docetaxel - 2 cyclophosphamide, methotrexate, 5-fluorouracile; Trastuzumab)
Bossi et al. (2017): A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high-dose cisplatin + (HEC with cisplatin (single dose >50 mg/m2 every 21 or 28 day)