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List of results

Argyriou et al. (2006): A randomized controlled trial evaluating the efficacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: final results + (Cisplatin-based chemotherapy)
Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial + (Cisplatin-based chemotherapy (few patients with carboplatin or oxaliplatin))
Pace et al. (2010): Vitamin E neuroprotection for cisplatin neuropathy + (Cisplatin-based chemotherapy, cisplatin was administered in combination regimens on the basis of the specific tumor site)
Pace et al. (2003): Neuroprotective Effect of Vitamin E Supplementation in Patient Treated With Cisplatin Chemotherapy + (Cisplatin-based chemotherapy; Cisplatin w … Cisplatin-based chemotherapy;Cisplatin was administered in combination regimens based on the specific tumor site as follows: Lung and urethral cancer:cisplatin 75 mg/m² on day 1 and gemcitabine 1,000 mg/m² on day 1 and day 8 every 3 weeks; ovarian cancer: cisplatin 75 mg/m² and endoxan 600 mg/m² on day 1 every 3 weeks; head and neck cancer: cisplatin 100 mg/m² on day 1 and fluorouracil 1,000 mg/m² on day 1 to 4 every 3 to 4 weeks; ethmoidal cancer: cisplatin 25 mg/m² and etoposide 80 mg/m² on day 1 to 3 every 3 weeks; gastric cancer: PELF regimen (cisplatin 40 mg/m² and epirubicin 30 mg/m² on days 1 and 5 plus fluorouracil 300 mg/m² and folinic acid 100 mg/m² on days 1 to 4 every 3 weeks); testicular cancer: PEB regimen (cisplatin 20 mg/m² and etoposide 100 mg/m² on days 1 to 5 plus bleomycin 30 mg on days 2, 9, and 16 every 3 weeks) 30 mg on days 2, 9, and 16 every 3 weeks))
Mahmoodnia et al. (2017): Ameliorative effect of lycopene effect on cisplatin-induced nephropathy in patients + (Cisplatin-chemotherapy)
Villani et al. (2016): Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial + (Cisplatin-chemotherapy)
Asfour et al. (2006): Effect of high-dose sodium selenite therapy on polymorphonuclear leukocyte apoptosis in non-Hodgkin's lymphoma patients + (Combination chemotherapy composed of cyclo … Combination chemotherapy composed of cyclophosphamide doxorubicin, oncovine, and prednisone (CHOP), treatment consisted of sisted of 750 mg/m2 on first day of the treatment cycle intravenously (IV) cyclophosphamide, 50 mg/m2 IV doxorubicin, 1.4 mg/m2 IV vincristine, and 100 mg po days 1 to 5 prednisone; chemotherapy cycles were repeated every 28 daystherapy cycles were repeated every 28 days)
Mantovani et al. (2010): Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia + (Concomitant antineoplastic palliative chemotherapy in 77.1-81.8% of patients per arm, NI on percentage of patients receiving hormone therapy)
Puri et al. (2010): Lycopene in treatment of high-grade gliomas: A pilot study + (Concurrent chemotherapy with paclitaxel at a dose of 60 mg/m2i/v weekly)
Ng et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial + (Continuous infusion of 2400 mg/m … Continuous infusion of 2400 mg/m2 of 5-fluorouracil (5-FU) over 46 to 48 hours, a bolus of 400 mg/m2 of 5-FU, 400 mg/m2 of leucovorin, and 85 mg/m2 of oxaliplatin (mFOLFOX6) plus 5 mg/kg of bevacizumab administered intravenously every 14 days per institutional standard of care (1 cycle=14 days), bevacizumab was allowed to be omitted during the first cycle and started with cycle 2 at the investigator’s discretione omitted during the first cycle and started with cycle 2 at the investigator’s discretion)
Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial + (Continuous infusion of 2400 mg/m … Continuous infusion of 2400 mg/m2 of 5-fluorouracil (5-FU) over 46 to 48 hours, a bolus of 400 mg/m2 of 5-FU, 400 mg/m2 of leucovorin, and 85 mg/m2 of oxaliplatin (mFOLFOX6) plus 5 mg/kg of bevacizumab administered intravenously every 14 days per institutional standard of care (1 cycle=14 days), bevacizumab was allowed to be omitted during the first cycle and started with cycle 2 at the investigator’s discretione omitted during the first cycle and started with cycle 2 at the investigator’s discretion)
Martin et al. (2002): Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial + (Curative surgery per arm for: 23 carcinom … Curative surgery per arm for:23 carcinomas of the rectosigmoid(enzyme arm: 9; placebo arm: 14)17 endometrial carcinoma (enzyme arm: 8; placebo arm: 9) 14 uterine cervix cancer (enzyme arm: 11; placebo arm: 3), 1 carcinoma of the vulva (enzyme arm: 0; placebo arm: 1)1 prostate cancer (enzyme arm: 0; placebo arm: 1)e cancer (enzyme arm: 0; placebo arm: 1))
Newling et al. (1995): Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group + (Cystoscopy and resection/fulguration of all recurrences were performed every 3 months during the first year and every 6 months thereafter.)
Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis + (Daily fraction was 180 cGy to 200 cGy in f … Daily fraction was 180 cGy to 200 cGy in five weekly fractions,total dose prescribed was 7,000 cGy;No significant difference in the radiation dose, fraction, and duration was identified between intervention and placebo arm; all patients received concomitant chemotherapy with 5-fluorouracil and cis-platinumerapy with 5-fluorouracil and cis-platinum)
Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer + (Docetaxel was supplied commercially. Patients received, on a 28-day cycle, 35 mg/m2 docetaxel i.v. on days 1, 8, and 15 over 1 hour)
Ota et al. (2014): The effect of pyridoxine for prevention of hand-foot-syndrome in colorectal cancer patients with adjuvant chemotherapy using capecitabine: A randomized study + (Eight 3-week cycles of 2,500 mg/m2 of capecitabine per day in two divided doses for 14 days, followed by a 7-day rest period)
Jeon et al. (2016): Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial + (Elective laparoscopic colectomy)
Hejazi et al. (2013): A pilot clinical trial of radioprotective effects of curcumin supplementation in patients with prostate cancer + (External beam radiotherapy (EBRT), in combination with hormone ablation)
Hejazi et al. (2016): Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study + (External beam radiotherapy (EBRT), in combination with hormone ablation)
Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation + (External beam radiotherapy: LINAC or Cobal … External beam radiotherapy: LINAC or Cobalt-10, total mean radiation dose (SD): 62.3 (9.13), radiotherapy duration (wks) (SD): 7.38 (1.28);daily fractions of 180– 200 cGy lasting from 5 to 9 weeks, for a total dose of 45-70 Gy, the radiation fields were the same for all patients, and the tongue was always includedtients, and the tongue was always included)
Muecke et al. (2010): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology + (External radiotherapy was delivered with a … External radiotherapy was delivered with a 6- to 18-MV linear accelerator. Five fractions per week were planned. Treatment was given with a three- to four-field box technique. Radiotherapy was given as three-dimensional conformal radiotherapy. Computed tomography–based treatment planning was performed in all cases. The clinical target volume encompassed the primary tumor region and the pelvic regional lymph nodes. High-dose rate brachytherapy of the vagina was considered optional in accordance with German evidence-based guidelines. Brachytherapy was delivered by iridium 192 afterloading.was delivered by iridium 192 afterloading.)
Muecke et al. (2013): Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology-a subgroup analysis of a multicenter, phase III trial + (External radiotherapy was delivered with a … External radiotherapy was delivered with a 6- to 18-MV linear accelerator. Five fractions per week were planned. Treatment was given with a three- to four-field box technique. Radiotherapy was given as three-dimensional conformal radiotherapy. Computed tomography–based treatment planning was performed in all cases. The clinical target volume encompassed the primary tumor region and the pelvic regional lymph nodes. High-dose rate brachytherapy of the vagina was considered optional in accordance with German evidence-based guidelines. Brachytherapy was delivered by iridium 192 afterloading.was delivered by iridium 192 afterloading.)
Özdelikara et al. (2017): The Effect of Reflexology on Chemotherapy-induced Nausea, Vomiting, and Fatigue in Breast Cancer Patients + (First chemotherapy cycle between April 2011 and October 2013)
Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study + (First cycle of AC chemotherapy)
Jacot et al. (2016): Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study + (Fluorouracil 500 mg/m2</sup& … Fluorouracil 500 mg/m2 , epirubicin 100 mg/m2 and cyclophosphamide 500 mg/m2 (FEC) i.v. on day 1 every 21 days for three cycles, followed by docetaxel 100 mg/m2 i.v. on day 1 every 21 days for three cycles;Docetaxel - 2 cyclophosphamide, methotrexate, 5-fluorouracile;Trastuzumabes; Docetaxel - 2 cyclophosphamide, methotrexate, 5-fluorouracile; Trastuzumab)

Bossi et al. (2017): A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high-dose cisplatin + (HEC with cisplatin (single dose >50 mg/m2 every 21 or 28 day)

Shooriabi et al. (2016): The effect of ginger extract on radiotherapy-oriented salivation in patients with xerostomia: A double-blind controlled study + (Head and neck radiotherapy)
Okabayashi et al. (2020): L-Carnitine Improves Postoperative Liver Function in Hepatectomized Patients + (Hepatectomy (n=30 bisegmentectomy or extended hepatectomy, n=69 segmentectomy, and n=109 subsegmentectomy))
Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer + (In all patients: High (>90%) emetic risk * 5-Flouracil + epirubicin + cyclophosphamide (FEC): 45% (SD 75.0) * Docetaxel + doxorubicin and cyclophosphamide (TAC): 7% (SD 11.7) Low (10—30%) emetic risk * Docetaxel: 8% (SD 13.3))
Salihah et al. (2016): The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting + (In all patients: High (>90%) emetic risk * 5-Flouracil + epirubicin + cyclophosphamide (FEC): 45% (SD 75.0) * Docetaxel + doxorubicin and cyclophosphamide (TAC): 7% (SD 11.7) Low (10—30%) emetic risk * Docetaxel: 8% (SD 13.3))
Montazeri et al. (2013): Eﬀect of Herbal Therapy to Intensity Chemotherapy-Induced Nausea and Vomiting in Cancer Patients + (In: ≥2 cycles of cisplatin chemotherapy Chemoregime: 50-100 mg cisplatin +/- others)
Raei et al. (2013): Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients + (In: ≥2 cycles of cisplatin chemotherapy Chemoregime: 50-100 mg Cisplatin +/- andere Antiemetika: Granisetron 3 mg + Dexamethazon 8mg)
Scher et al. (2011): Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer + (Intervention arm: 36 mg/m2</ … Intervention arm: 36 mg/m2 docetaxel for 30-minute infusion on days 2, 9, and 16; and 8-mg oral dexamethasone about 12 hours, 3 hours, and 1 hour before docetaxel; nine doses of dexamethasone per 28-day, continued for up to 30 weeks or until unacceptable docetaxel toxicity or clinical disease progressionControl arm: 1-hour infusion of docetaxel at 75 mg/m2 body-surface area on day 2; and 8-mg oral dexamethasone about 12 hours, 3 hours, and 1 hour before docetaxel infusion; three doses per 21-day cycle, continued for up to 30 weeks or until unacceptable docetaxel toxicity or clinical disease progressionil unacceptable docetaxel toxicity or clinical disease progression)
Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study + (Intervention arm: Dose of radiotherapy (cG … Intervention arm: Dose of radiotherapy (cGy): 6,824 (463.5), Placebo arm: Dose of radiotherapy (cGy): 6,651 (1,056.3);Intervention arm: Duration of radiotherapy: 56 (8.7), Placebo arm: Duration of radiotherapy: 54 (11.8);Intervention arm: concurrent chemotherapy: 20 (41), Placebo arm: concurrent chemotherapy: 20 (42)cebo arm: concurrent chemotherapy: 20 (42))
Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study + (Intervention arm: Dose of radiotherapy (cG … Intervention arm: Dose of radiotherapy (cGy): 6,824 (463.5),Placebo arm: Dose of radiotherapy (cGy): 6,651 (1,056.3);Intervention arm: Duration of radiotherapy: 56 (8.7),Placebo arm: Duration of radiotherapy: 54 (11.8);Intervention arm: concurrent chemotherapy: 20 (41)Placebo arm: concurrent chemotherapy: 20 (42)cebo arm: concurrent chemotherapy: 20 (42))
Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial + (Irradiation of the entire brain or at least 60 % with a dose of 30-60 Gray fractionated over 5 x 1.8-3.0 Gray/week)
Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer. + (Major abdominal surgery for mainly hepatocellular cancer and gastric cancer in the 24 hours)
Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture + (Mean times from the last chemotherapy, last surgery, or last radiotherapy were comparable between groups (all 𝑃 values >0.25))
Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial + (Mean value (range) Radiation dose Aloe ar … Mean value (range) Radiation doseAloe arm: 65.54 (50-70) GyPlacebo arm : 66.15 (54 - 70) GyPrevious chemotherapy per arm: Aloe arm: yes = 9 (69.2%); no = 4 (30.8%)Placebo arm: yes = 12 (92.3%); no = 1 (7.7%)Histology: SCC: Aloe arm = 11 (84.6%); Placebo arm = 12 (92.3%)Mucoepidermoid carcinoma: Aloe arm = 1 (7.7%); Placebo arm = 0 Osteosarcoma: Aloe arm = 1 (7.7%); Placebo arm = 1 (7.7%)loe arm = 1 (7.7%); Placebo arm = 1 (7.7%))
Gorgu et al. (2013): The effect of zinc sulphate in the prevention of radiation induced oral mucositis in patents with head and neck cancer + (Median radiation dose in all the patients was 6440 cGy (range: 4600‐7000 cGy); intervention arm: 6625 cGy (range: 6000‐7000 cGy) vs. control arm: 6316 cGy (range: 4600‐7000 cGy); n=20 with concurrent chemotherapy; n=24 with surgery before radiotherapy)
Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer + (Minimum of 6 months since completion of br … Minimum of 6 months since completion of breast surgery, adjuvant chemotherapy (including trastuzumab), and radiation therapyBreast cancer treatments: n(%)Chemotherapy: Poly E arm 29(97); Placebo arm 10(100)Trastuzumab: Poly E arm 5(17); Placebo arm 2(20)Radiation therapy: Poly E arm 23(77); Placebo arm 8(80)rapy: Poly E arm 23(77); Placebo arm 8(80))
Grimison et al. (2020): Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial + (Moderate-to-high emetogenic intravenous chemotherapy Chemotherapy regimen, n(%): Doxorubicin + cyclophosphamide = 20 (26) FOLFOX ± biological = 13 (17) Cisplatin based = 12 (15) FOLFIRINOX = 6 (8) Other = 27 (35))
Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy + (Moderately to highly emetogenic chemotherapy: 93% highly emetogenic, of which 68% anthracycline-based and 21% platinum-based)
Stratton et al. (2010): Oral Selenium Supplementation Has No Effect on Prostate- Specific Antigen Velocity in Men Undergoing Active Surveillance for Localized Prostate Cancer + (NA)
Goossens et al. (2016): Phase III randomised chemoprevention study with selenium on the recurrence of non-invasive urothelial carcinoma. The SELEnium and BLAdder cancer Trial + (NA)
Karp et al. (2012): Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597 + (NA)
Paur et al. (2017): Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA + (NA)
Muecke et al. (2014): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology: follow-up analysis of the survival data 6 years after cessation of randomization + (NA)
Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer + (NA)
Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial + (NA)
Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis + (NA)