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- Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + (Patients, for whom no other effective stan … Patients, for whom no other effective standard therapy was available, because of lack of response to previous chemotherapies or a poor clinical status precluding chemotherapy.</br></br></br>Previous chemotherapy </br></br>(patients were eligible after at least 1 month from the last chemotherapy course):</br></br>Aloe arm: 20/24</br></br>Control arm: 21/26rse): Aloe arm: 20/24 Control arm: 21/26)