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List of results

Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer + (NI)
Wyatt et al. (2012): Health-Related Quality-of-Life Outcomes: A Reflexology Trial With Patients With Advanced-Stage Breast Cancer + (NI)
Mansouri et al. (2016): The Effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial + (NI)
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients + (NI)
Lin et al. (2010): Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: subgroup analysis of a double-blind, randomized study + (Nasopharyngeal Cancer: daily fractionation … Nasopharyngeal Cancer: daily fractionations of 180 cGy to 200 cGy in 5 weekly fractions; total dose: 7000 cGyOral Cancer: 7000 cGy was given to patients without surgery and 6000 cGy was prescribed as adjuvant treatment if they received an operation,unilateral irradiation was performed for cancers arising from retromolar, unilateral gum, lip, or single focus of buccal mucosa; whereas bilateral irradiation was done for tumors arising from mouth floor or multiple foci of buccal mucosath floor or multiple foci of buccal mucosa)
Mazdak et al. (2012): Vitamin E reduces superficial bladder cancer recurrence: A randomized controlled Trial + (No intravesical chemotherapy)
Johnson et al. (2010): Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain + (No therapy in the last 2 weeks)
Su et al. (2004): Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms + (Of the 58 patients, 41% underwent primary surgical resection with adjuvant radiotherapy, and 59% received definitive radiotherapy; 41% of patients also received concurrent chemotherapy. Chemotherapy per arm: Aloe arm: 36% Placebo arm: 47%)
Rao et al. (2014): The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study + (Only radiation therapy, radiation therapy + chemotherapy or radiation therapy + chemotherapy + surgery)
Koyama et al. (2017): Intravenous Carnitine Administration in Addition to Parenteral Nutrition With Lipid Emulsion May Decrease the Inflammatory Reaction in Postoperative Surgical Patients + (Open or Laparoscopic surgery for gastric or colorectal cancer + Peripheral postoperative parenteral nutrition (PPN): glucose, amino acid, lipid emulsion)
Akiba et al. (2018): Vitamin D Supplementation and Survival of Patients with Non–small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial + (Oral or injection chemotherapy was administered to the patients according to the stage, except in stage IA and tumor size less than 2 cm)
Vitale et al. (2020): ZeOxaNMulti Trial: A Randomized, Double-Blinded, Placebo-Controlled Trial of Oral PMA-Zeolite to Prevent Chemotherapy-Induced Side Effects, in Particular, Peripheral Neuropathy + (Oxaliplatin, 1. or 2. line)
Afonseca et al. (2013): Vitamin E for prevention of oxaliplatin-induced peripheral neuropathy: A pilot randomized clinical trial + (Oxaliplatin-based chemotherapy + calcium and magnesium supplements before and after oxaliplatin infusions)
Salehi et al. (2015): Effect of Vitamin E on Oxaliplatin-induced Peripheral neuropathy Prevention: A Randomized Controlled Trial + (Oxiplatin-based chemotherapy (oxaliplatin … Oxiplatin-based chemotherapy (oxaliplatin + 5‑fluorouracil + leucovorin (FOLFOX4); oxaliplatin: 85 mg/m 2 intravenous (IV) on day 1, 5‑fluorouracil: 400 mg/m 2 IV bolus, followed by 600 mg/m 2 IV continuous infusion for 22 h on days 1 and 2, leucovorin: 200 mg/m 2 IV on days 1 and 2 as a 2‑h infusion before 5‑fluorouracil)2 as a 2‑h infusion before 5‑fluorouracil))
Argyriou et al. (2006): Preventing Paclitaxel-Induced Peripheral neuropathy: A Phase 2 Trial of Vitamin E Supplementation + (Paclitaxel-based chemotherapy)
Panahi et al. (2012): Effect of Ginger on Acute and Delayed Chemotherapy-Induced Nausea and Vomiting: A Pilot, Randomized, Open-Label Clinical Trial + (Patients experiencing their first trial of chemotherapy (Docetaxel, Epirubicin, Cyclophosphamid))
Zick et al. (2008): Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting + (Patients must have had at least one previous round of chemotherapy.)
Nguyen et al. (2012): Randomized, Double-Blind, Placebo-Controlled Trial of Polyphenon E in Prostate Cancer Patients before Prostatectomy: Evaluation of Potential Chemopreventive Activities + (Patients received no other therapy for their prostate cancer; no history of chemotherapy and/or radiation for any malignancy in the previous 5 years)
Emami et al. (2014): Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of green tea in preventing acute gastrointestinal complications due to radiotherapy + (Patients receiving standardized abdomen an … Patients receiving standardized abdomen and pelvic irradiation 5000 cGy (1000 cGy weekly)Cancer treatments: per arm n(%)Radiotherapy + chemotherapy: green tea arm 8(38.1); Placebo arm 7(33.3)Radiotherapy + surgery: green tea arm 16(76.2); Placebo arm 16(76.2)een tea arm 16(76.2); Placebo arm 16(76.2))
Vinzenz et al. (1992): Die Therapie der radiogenen Mukositis mit Enzymen + (Patients underwent preoperative radiotherapy)
Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients + (Patients who underwent cytoreductive surgery followed by platinum-based adjuvant chemotherapy)
Wrbka et al. (1987): Unterstützung der Chemotherapie inoperabler Karzinome durch proteolytische Fermente + (Patients with untreated inoperable bronchopulmonary carcinomas of various entities; 4 out of 51 patients had previously undergone surgery or radiotherapy for carcinoma in another organ)
Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + (Patients, for whom no other effective stan … Patients, for whom no other effective standard therapy was available, because of lack of response to previous chemotherapies or a poor clinical status precluding chemotherapy.Previous chemotherapy (patients were eligible after at least 1 month from the last chemotherapy course):Aloe arm: 20/24Control arm: 21/26rse): Aloe arm: 20/24 Control arm: 21/26)
Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study + (Planned concurrent chemotherapy, %, per ar … Planned concurrent chemotherapy, %, per arm* None: Megestrol Acetate = 30; Dronabinol = 30; Megestrol Acetate + Dronabinol= 30* With cisplatinum: Megestrol Acetate = 15; Dronabinol = 14; Megestrol Acetate + Dronabinol = 14* Without cisplatinum: Megestrol Acetate= 55; Dronabinol = 56; Megestrol Acetate + Dronabinol = 56Planned concurrent radiation, %* Yes: Megestrol Acetate = 21; Dronabinol = 20; Megestrol Acetate + Dronabinol = 20* No: Megestrol Acetate = 79; Dronabinol = 80; Megestrol Acetate + Dronabinol = 80 = 80; Megestrol Acetate + Dronabinol = 80)
Halyard et al. (2007): Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4) + (Planned radiation dose ≥6,000 vs. ≤6,000 cGy; n=71 with concomitant chemotherapy anticipated)

Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy + (Post-Surgery: bilateral nerve-sparing radical retropubic prostatectomy)

Fallahi et al. (2013): Does vitamin E protect salivary glands from I-131 radiation damage in patients with thyroid cancer? + (Postsurgical ablation therapy with 3700–5550MBq 131I)
Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial + (Preoperative and postoperative chemotherap … Preoperative and postoperative chemotherapy was administered to patients with stage II and III esophageal cancer; postoperative chemotherapy was administered to patients with stage II and III gastric cancer and all patients with stage III colorectal cancer;Local radiation or molecular-targeting therapy was combined with chemotherapy for selected patients with relapsetherapy for selected patients with relapse)
Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy + (Previous Satraplatin or Vincristine chemotherapy, but not recently or at the time of the study)
Puataweepong et. al (2009): The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: a double-blind placebo-controlled study + (Previous surgery Aloe arm: 4 (13%) Placebo arm: 12 (38%) Chemotherapy Aloe arm: yes = 17 (57%); no = 13 (43%) Placebo arm: yes = 18 (58%); no = 13 (42%))
Jyothirmayi et al. (1996): Efficacy of Vitamin A in the Prevention of Locoregional Recurrence and Second Primaries in Head and Neck Cancer + (Previous treatment per group: - intervention: 44x radiotherapy, 3x surgery, 3x radiotherapy + surgery - placebo: 47x radiotherapy, 5x surgery, 4x radiotherapy + surgery)
Sangthawan et al. (2013): A randomized double-blind, placebo-controlled trial of zinc sulfate supplementation for alleviation of radiation-induced oral mucositis and pharyngitis in head and neck cancer patients + (Radiation therapy alone or as postoperative radiation therapy, all patients were treated with Cobalt-60 or 6 MV photon machine, daily fractionation was 1.8 to 2 Gy, a total dose of 50 to 70 Gy over 5 to 7 weeks was administered)
Nasser et al. (2017): Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients + (Radiation therapy to the involved breast w … Radiation therapy to the involved breast was delivered by two tangential fields, delivered as a single fraction per day, 5 days a week;radiation dose was either 42.72 Gy in 16 fractions or 50 Gy in 25 fractions, when indicated, a boost was provided to the tumor bed, to a total dose of 10 Gy administered in 5 fractions of 2 Gy eachy administered in 5 fractions of 2 Gy each)
Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial + (Radiation therapy with 2 tangential fields with a photonbeam energy of 6 Mv 50 Gy, 5 doses weekly about 5 weeks)
Stauder et al. (1991): Strahlentherapeutische Nebenwirkungen bei Abdominalkrebspatienten und deren Reduktion durch hydrolytische Enzyme + (Radiation treatment of patients with inoperable abdominal cancer or postoperative radiotherapy of abdominal cancer due to lymph node involvement.)
Margalit et al. (2012): Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study + (Radiation type per group: - intervention: 129x external beam radiation, 39x brachytherapy, 21x both, 2x unknown or missing - placebo: 133x external beam radiation, 40x brachytherapy, 16x both, 3x unknown or missing)
Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial + (Radioiodine therapy (131I))
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (Radiotherapy consisted of 30 daily session … Radiotherapy consisted of 30 daily sessions lasting six weeks (total dose = 5,040 cGys in the supraclavicular fossa and lymphatic drainages and reaching 7,040 cGys in the tumor).Platinum-based chemotherapy consisted of three cycles of cisplatin (100 mg/m2) every 21 days during the chemoradiotherapy.very 21 days during the chemoradiotherapy.)
Moslemi et al. (2014): Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial + (Radiotherapy doses (cGy) Range: 4000-7000; concurrent chemoradiotherapy: n=32)
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (Radiotherapy only: intervention arm = 13 … Radiotherapy only: intervention arm = 13; placebo arm = 10Radiotherapy postoperative: intervention arm = 7; placebo arm = 2Radiochemotherapy: intervention arm = 7; placebo arm = 15Radiochemotherapy postoperative: intervention arm = 1, placebo arm = 1e: intervention arm = 1, placebo arm = 1)
Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck + (Radiotherapy: 70 Gy at 2 Gy per fraction in 35 daily treatments, 5 days a week for 7 weeks, chemotherapy: Cisplatin dosed at 100 mg/m² intravenously over 3h in 1000mL saline on days 1, 22, and 43 of radiotherapy)
Watanabe et al. (2010): Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer + (Radiotherapy: n=10, Radiochemotherapy: n=21)
Toma et al. (2003): β-carotene supplementation in patients radically treated for stage I-II head and neck cancer: Results of a randomized trial + (Randomization within 1 month after assessment of complete response to treatment)
Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial + (Receiving chemoradiationtherapy during postoperative and preoperative periods)
Antunac et al. (2018): Vitamin D Supplementation and Survival in Metastatic Colorectal Cancer + (Regimen: FOLFIRI, Oxaliplatinum based or 5 FU-based)
Howells et al. (2011): Phase I randomised double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases - safety, pharmacokinetics and pharmacodynamics + (Resection of liver metastases)
Yap et al. (2017): Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: a randomized clinical trial + (Single-agent capecitabine chemotherapy)
Özdelikara et al. (2017): The effect of reflexology on the quality of life with breast cancer patients + (Standard antiemetic doses)
Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients + (Standard fractionated RT (~1.8–2.4 Gy per session) for four to seven weeks with or without boost for a total radiation dose of ≥ 42 Gy Prior (n(%)): * Lumpectomy 27 (90%) * Mastectomy 3 (10%) * Chemotherapy before radiation 13 (43.3%))
Henning et al. (2015): Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy + (Study setting is prior to surgery.)
Kessels et al. (2017): Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma A Randomized Clinical Trial + (Study setting is prior to surgery.)