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- Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (Radiotherapy consisted of 30 daily session … Radiotherapy consisted of 30 daily sessions lasting six weeks (total dose = 5,040 cGys in the supraclavicular fossa and lymphatic drainages and reaching 7,040 cGys in the tumor).</br>Platinum-based chemotherapy consisted of three cycles of cisplatin (100 mg/m2) every 21 days during the chemoradiotherapy.very 21 days during the chemoradiotherapy.)