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List of results

Vinzenz et al. (1992): Die Therapie der radiogenen Mukositis mit Enzymen + (Patients underwent preoperative radiotherapy)
Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients + (Patients who underwent cytoreductive surgery followed by platinum-based adjuvant chemotherapy)
Wrbka et al. (1987): Unterstützung der Chemotherapie inoperabler Karzinome durch proteolytische Fermente + (Patients with untreated inoperable bronchopulmonary carcinomas of various entities; 4 out of 51 patients had previously undergone surgery or radiotherapy for carcinoma in another organ)
Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms + (Patients, for whom no other effective stan … Patients, for whom no other effective standard therapy was available, because of lack of response to previous chemotherapies or a poor clinical status precluding chemotherapy.Previous chemotherapy (patients were eligible after at least 1 month from the last chemotherapy course):Aloe arm: 20/24Control arm: 21/26rse): Aloe arm: 20/24 Control arm: 21/26)
Jatoi et al. (2002): Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study + (Planned concurrent chemotherapy, %, per ar … Planned concurrent chemotherapy, %, per arm* None: Megestrol Acetate = 30; Dronabinol = 30; Megestrol Acetate + Dronabinol= 30* With cisplatinum: Megestrol Acetate = 15; Dronabinol = 14; Megestrol Acetate + Dronabinol = 14* Without cisplatinum: Megestrol Acetate= 55; Dronabinol = 56; Megestrol Acetate + Dronabinol = 56Planned concurrent radiation, %* Yes: Megestrol Acetate = 21; Dronabinol = 20; Megestrol Acetate + Dronabinol = 20* No: Megestrol Acetate = 79; Dronabinol = 80; Megestrol Acetate + Dronabinol = 80 = 80; Megestrol Acetate + Dronabinol = 80)
Halyard et al. (2007): Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4) + (Planned radiation dose ≥6,000 vs. ≤6,000 cGy; n=71 with concomitant chemotherapy anticipated)
Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy + (Post-Surgery: bilateral nerve-sparing radical retropubic prostatectomy)
Fallahi et al. (2013): Does vitamin E protect salivary glands from I-131 radiation damage in patients with thyroid cancer? + (Postsurgical ablation therapy with 3700–5550MBq 131I)
Urashima et al. (2019): Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers The AMATERASU Randomized Clinical Trial + (Preoperative and postoperative chemotherap … Preoperative and postoperative chemotherapy was administered to patients with stage II and III esophageal cancer; postoperative chemotherapy was administered to patients with stage II and III gastric cancer and all patients with stage III colorectal cancer;Local radiation or molecular-targeting therapy was combined with chemotherapy for selected patients with relapsetherapy for selected patients with relapse)
Sun et al. (2016): A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy + (Previous Satraplatin or Vincristine chemotherapy, but not recently or at the time of the study)
Puataweepong et. al (2009): The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: a double-blind placebo-controlled study + (Previous surgery Aloe arm: 4 (13%) Placebo arm: 12 (38%) Chemotherapy Aloe arm: yes = 17 (57%); no = 13 (43%) Placebo arm: yes = 18 (58%); no = 13 (42%))
Jyothirmayi et al. (1996): Efficacy of Vitamin A in the Prevention of Locoregional Recurrence and Second Primaries in Head and Neck Cancer + (Previous treatment per group: - intervention: 44x radiotherapy, 3x surgery, 3x radiotherapy + surgery - placebo: 47x radiotherapy, 5x surgery, 4x radiotherapy + surgery)
Sangthawan et al. (2013): A randomized double-blind, placebo-controlled trial of zinc sulfate supplementation for alleviation of radiation-induced oral mucositis and pharyngitis in head and neck cancer patients + (Radiation therapy alone or as postoperative radiation therapy, all patients were treated with Cobalt-60 or 6 MV photon machine, daily fractionation was 1.8 to 2 Gy, a total dose of 50 to 70 Gy over 5 to 7 weeks was administered)
Nasser et al. (2017): Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients + (Radiation therapy to the involved breast w … Radiation therapy to the involved breast was delivered by two tangential fields, delivered as a single fraction per day, 5 days a week;radiation dose was either 42.72 Gy in 16 fractions or 50 Gy in 25 fractions, when indicated, a boost was provided to the tumor bed, to a total dose of 10 Gy administered in 5 fractions of 2 Gy eachy administered in 5 fractions of 2 Gy each)
Togni et al. (2015): Clinical evaluation of safety and efficacy of Boswellia-based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: a randomized placebo controlled trial + (Radiation therapy with 2 tangential fields with a photonbeam energy of 6 Mv 50 Gy, 5 doses weekly about 5 weeks)
Stauder et al. (1991): Strahlentherapeutische Nebenwirkungen bei Abdominalkrebspatienten und deren Reduktion durch hydrolytische Enzyme + (Radiation treatment of patients with inoperable abdominal cancer or postoperative radiotherapy of abdominal cancer due to lymph node involvement.)
Margalit et al. (2012): Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study + (Radiation type per group: - intervention: 129x external beam radiation, 39x brachytherapy, 21x both, 2x unknown or missing - placebo: 133x external beam radiation, 40x brachytherapy, 16x both, 3x unknown or missing)
Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial + (Radioiodine therapy (131I))
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (Radiotherapy consisted of 30 daily session … Radiotherapy consisted of 30 daily sessions lasting six weeks (total dose = 5,040 cGys in the supraclavicular fossa and lymphatic drainages and reaching 7,040 cGys in the tumor).Platinum-based chemotherapy consisted of three cycles of cisplatin (100 mg/m2) every 21 days during the chemoradiotherapy.very 21 days during the chemoradiotherapy.)
Moslemi et al. (2014): Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial + (Radiotherapy doses (cGy) Range: 4000-7000; concurrent chemoradiotherapy: n=32)
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (Radiotherapy only: intervention arm = 13 … Radiotherapy only: intervention arm = 13; placebo arm = 10Radiotherapy postoperative: intervention arm = 7; placebo arm = 2Radiochemotherapy: intervention arm = 7; placebo arm = 15Radiochemotherapy postoperative: intervention arm = 1, placebo arm = 1e: intervention arm = 1, placebo arm = 1)
Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck + (Radiotherapy: 70 Gy at 2 Gy per fraction in 35 daily treatments, 5 days a week for 7 weeks, chemotherapy: Cisplatin dosed at 100 mg/m² intravenously over 3h in 1000mL saline on days 1, 22, and 43 of radiotherapy)
Watanabe et al. (2010): Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer + (Radiotherapy: n=10, Radiochemotherapy: n=21)
Toma et al. (2003): β-carotene supplementation in patients radically treated for stage I-II head and neck cancer: Results of a randomized trial + (Randomization within 1 month after assessment of complete response to treatment)
Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial + (Receiving chemoradiationtherapy during postoperative and preoperative periods)

Antunac et al. (2018): Vitamin D Supplementation and Survival in Metastatic Colorectal Cancer + (Regimen: FOLFIRI, Oxaliplatinum based or 5 FU-based)

Howells et al. (2011): Phase I randomised double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases - safety, pharmacokinetics and pharmacodynamics + (Resection of liver metastases)
Yap et al. (2017): Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: a randomized clinical trial + (Single-agent capecitabine chemotherapy)
Özdelikara et al. (2017): The effect of reflexology on the quality of life with breast cancer patients + (Standard antiemetic doses)
Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients + (Standard fractionated RT (~1.8–2.4 Gy per session) for four to seven weeks with or without boost for a total radiation dose of ≥ 42 Gy Prior (n(%)): * Lumpectomy 27 (90%) * Mastectomy 3 (10%) * Chemotherapy before radiation 13 (43.3%))
Henning et al. (2015): Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy + (Study setting is prior to surgery.)
Kessels et al. (2017): Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma A Randomized Clinical Trial + (Study setting is prior to surgery.)
Walsh et al. (2010): Use of alpha,25-dihydroxyvitamin D3 treatment to stimulate immune infiltration into head and neck squamous cell carcinoma + (Surgical excision)
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study + (Systemic chemotherapy)
Keshavarzi et al. (2019): The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer + (Tamoxifen)
Barton et al. (1998): Prospective evaluation of vitamin E for hot flashes in breast cancer survivors + (Tamoxifen use in 59% (intervention arm) and 60% (placebo arm))
Kottschade et al. (2011): The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase 3 clinical trial + (Taxan (58%), Cisplatin (4%), Carboplatin (1%), Oxaliplatin (26%), Combination (11%))
Hershman et al. (2013): Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy + (Taxan-based chemotherapy; paclitaxel 80 mg … Taxan-based chemotherapy; paclitaxel 80 mg/m2 once per week for 12 cycles, paclitaxel 175 mg/m2 once every 2 weeks for four cycles, paclitaxel 175 mg/m2 once every 2 weeks for six cycles, docetaxel 75 mg/m2 once every 3 weeks for four cycles, or docetaxel 75 mg/m2 once every 3 weeks for six cycles weeks for four cycles, or docetaxel 75 mg/m2 once every 3 weeks for six cycles)
Hershman et al. (2018): Two-Year Trends of Taxane-Induced Neuropathy in Women Enrolled in a Randomized Trial of Acetyl-L Carnitine + (Taxan-based chemotherapy; paclitaxel 80 mg … Taxan-based chemotherapy; paclitaxel 80 mg/m2 once per week for 12 cycles, paclitaxel 175 mg/m2 once every 2 weeks for four cycles, paclitaxel 175 mg/m2 once every 2 weeks for six cycles, docetaxel 75 mg/m2 once every 3 weeks for four cycles, or docetaxel 75 mg/m2 once every 3 weeks for six cycles weeks for four cycles, or docetaxel 75 mg/m2 once every 3 weeks for six cycles)
Shamsaei et al. (2017): The Vitamin E Preventive Effect on Taxol-Induced Neuropathy Among Patients With Breast Cancer: A Randomized Clinical Trial + (Taxol-based chemotherapy)
Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial + (The high-dose chemotherapy included busulf … The high-dose chemotherapy included busulfan 4 mg/kg p.o. in divided doses daily for 4 days (total dose 16 mg/kg) followed by cyclophsophamide 60 mg/kg once daily i.v. for 2 days (total dose 120 mg/kg) + peripheral blood hematopoietic stem cells 1 day after completion of chemotherapylls 1 day after completion of chemotherapy)
Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study + (The location of the fungating malignant wounds were: breast (n=24), neck (n=2), groin (n=2), spine (n=1); anus (n=1))
Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial + (The patients undergoing general anesthesia … The patients undergoing general anesthesia were induced with thiopental sodium 5e7 mg/kg, fentanyl 5 mg/kg, midazolam 0.02 mg/kg, lidocaine 1 mg/kg, atracurium 0.5 mg/kg, endotracheal intubation, and maintained with propofol 50e150 mg/kg/min in a 3 L/min oxygen/air mixture. Eventually, the patient’s awakening was induced with neostigmine and atropine to an extent of 0.07 mg/kg and 0.02 mg/kg, respectively.f 0.07 mg/kg and 0.02 mg/kg, respectively.)
Cruciani et al. (2009): L-Carnitine Supplementation in Patients with Advanced Cancer and Carnitine Deficiency: A Double-Blind, Placebo-Controlled Study + (The protocol was amended during the course of the study, and patients receiving chemotherapy or radiation therapy were allowed under the modified protocol.)
Sahebnasagh et al. (2017): Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial + (The radiation dose was 50-70Gy (1.8-2Gy 5x per day))
Ehrenpreis et al. (2005): A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial of Retinol Palmitate (Vitamin A) for Symptomatic Chronic Radiation Proctopathy + (Time since radiation therapy ''mean (range)'': 4.35 years (0.67-19))
Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer + (Treatment intent: Definitive = 86 Postoperative = 18 Induction chemotherapy: Yes = 96 No = 8)
Dörr et al. (2007): Efficacy of Wobe-Mugos E for Reduction of Oral Mucositis after Radiotherapy + (Tumors were mainly located at tonsils (20. … Tumors were mainly located at tonsils (20.5%), floor of the mouth (15.7%), or tongue (margin:15.7%, base:12.0%, body:8.4%)Patients received surgery prior to radiotherapy in n (%): both arms together: 59 (85.5%)enzyme-arm: 33 (91.7%)placebo-arm: 26 (78.8%)Radiotherapy protocols comprised conventional fractionation with 1.8–2.0 Gy/fraction, 5× per week to total doses of 60–66 Gy per 6–7 weeks, or hyperfractionation with 2 × 1.2 Gy per day, 5× per week to a total dose of 72 Gy per 6–7 weeks.ek to a total dose of 72 Gy per 6–7 weeks.)
Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer + (Types of radiotherapy per arm: - intervention: 9x radiotherapy, 16x concurrent chemoradiotherapy - placebo: 6x radiotherapy, 14x concurrent chemoradiotherapy N for adjuvant/definitive setting per arm: - intervention: 15/10 - placebo:9/11)
Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (Weekly docetaxel 36 mg/m2 intravenously and dexamethasone (4 mg orally 12 hours before, 1 hour before, and 12 hours after docetaxel administration))
Frankling et al. (2021): ‘Palliative-D’ - Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial + (With no intention to cure)