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- Margalit et al. (2012): Beta-carotene Antioxidant Use During Radiation Therapy and Prostate Cancer Outcome in the Physicians’ Health Study + (Radiation type per group: - intervention: 129x external beam radiation, 39x brachytherapy, 21x both, 2x unknown or missing - placebo: 133x external beam radiation, 40x brachytherapy, 16x both, 3x unknown or missing)
- Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial + (Radioiodine therapy (131I))
- Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life + (Radiotherapy consisted of 30 daily session … Radiotherapy consisted of 30 daily sessions lasting six weeks (total dose = 5,040 cGys in the supraclavicular fossa and lymphatic drainages and reaching 7,040 cGys in the tumor).</br>Platinum-based chemotherapy consisted of three cycles of cisplatin (100 mg/m2) every 21 days during the chemoradiotherapy.very 21 days during the chemoradiotherapy.)
- Moslemi et al. (2014): Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled clinical trial + (Radiotherapy doses (cGy) Range: 4000-7000; concurrent chemoradiotherapy: n=32)
- Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial + (Radiotherapy only: intervention arm = 13 … Radiotherapy only: </br></br>intervention arm = 13; placebo arm = 10</br></br>Radiotherapy postoperative: </br></br>intervention arm = 7; placebo arm = 2</br></br>Radiochemotherapy: </br></br>intervention arm = 7; placebo arm = 15</br></br>Radiochemotherapy postoperative: </br></br>intervention arm = 1, placebo arm = 1e: intervention arm = 1, placebo arm = 1)
- Mix et al. (2015): Randomized phase II trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck + (Radiotherapy: 70 Gy at 2 Gy per fraction in 35 daily treatments, 5 days a week for 7 weeks, chemotherapy: Cisplatin dosed at 100 mg/m² intravenously over 3h in 1000mL saline on days 1, 22, and 43 of radiotherapy)
- Watanabe et al. (2010): Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer + (Radiotherapy: n=10, Radiochemotherapy: n=21)
- Toma et al. (2003): β-carotene supplementation in patients radically treated for stage I-II head and neck cancer: Results of a randomized trial + (Randomization within 1 month after assessment of complete response to treatment)
- Uysal et al. (2016): Effects of foot massage applied in two different methods on symptom control in colorectal cancer patients: Randomised control trial + (Receiving chemoradiationtherapy during postoperative and preoperative periods)
- Antunac et al. (2018): Vitamin D Supplementation and Survival in Metastatic Colorectal Cancer + (Regimen: FOLFIRI, Oxaliplatinum based or 5 FU-based)
- Howells et al. (2011): Phase I randomised double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases - safety, pharmacokinetics and pharmacodynamics + (Resection of liver metastases)
- Yap et al. (2017): Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: a randomized clinical trial + (Single-agent capecitabine chemotherapy)
- Özdelikara et al. (2017): The effect of reflexology on the quality of life with breast cancer patients + (Standard antiemetic doses)
- Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients + (Standard fractionated RT (~1.8–2.4 Gy per session) for four to seven weeks with or without boost for a total radiation dose of ≥ 42 Gy Prior (n(%)): * Lumpectomy 27 (90%) * Mastectomy 3 (10%) * Chemotherapy before radiation 13 (43.3%))
- Henning et al. (2015): Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy + (Study setting is prior to surgery.)
- Kessels et al. (2017): Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma A Randomized Clinical Trial + (Study setting is prior to surgery.)
- Walsh et al. (2010): Use of alpha,25-dihydroxyvitamin D3 treatment to stimulate immune infiltration into head and neck squamous cell carcinoma + (Surgical excision)
- Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study + (Systemic chemotherapy)
- Keshavarzi et al. (2019): The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer + (Tamoxifen)
- Barton et al. (1998): Prospective evaluation of vitamin E for hot flashes in breast cancer survivors + (Tamoxifen use in 59% (intervention arm) and 60% (placebo arm))
- Kottschade et al. (2011): The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase 3 clinical trial + (Taxan (58%), Cisplatin (4%), Carboplatin (1%), Oxaliplatin (26%), Combination (11%))
- Hershman et al. (2013): Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy + (Taxan-based chemotherapy; paclitaxel 80 mg … Taxan-based chemotherapy; paclitaxel 80 mg/m<sup>2</sup> once per week for 12 cycles, paclitaxel 175 mg/m<sup>2</sup> once every 2 weeks for four cycles, paclitaxel 175 mg/m<sup>2</sup> once every 2 weeks for six cycles, docetaxel 75 mg/m<sup>2</sup> once every 3 weeks for four cycles, or docetaxel 75 mg/m<sup>2</sup> once every 3 weeks for six cycles weeks for four cycles, or docetaxel 75 mg/m<sup>2</sup> once every 3 weeks for six cycles)
- Hershman et al. (2018): Two-Year Trends of Taxane-Induced Neuropathy in Women Enrolled in a Randomized Trial of Acetyl-L Carnitine + (Taxan-based chemotherapy; paclitaxel 80 mg … Taxan-based chemotherapy; paclitaxel 80 mg/m<sup>2</sup> once per week for 12 cycles, paclitaxel 175 mg/m<sup>2</sup> once every 2 weeks for four cycles, paclitaxel 175 mg/m<sup>2</sup> once every 2 weeks for six cycles, docetaxel 75 mg/m<sup>2</sup> once every 3 weeks for four cycles, or docetaxel 75 mg/m<sup>2</sup> once every 3 weeks for six cycles weeks for four cycles, or docetaxel 75 mg/m<sup>2</sup> once every 3 weeks for six cycles)
- Shamsaei et al. (2017): The Vitamin E Preventive Effect on Taxol-Induced Neuropathy Among Patients With Breast Cancer: A Randomized Clinical Trial + (Taxol-based chemotherapy)
- Jahangard-Rafsanjani et al. (2013): The efficacy of selenium in prevention of oral mucositis in patients undergoing hematopoietic SCT: a randomized clinical trial + (The high-dose chemotherapy included busulf … The high-dose chemotherapy included busulfan 4 mg/kg p.o. in divided doses daily for 4 days (total dose 16 mg/kg) followed by cyclophsophamide 60 mg/kg once daily i.v. for 2 days (total dose 120 mg/kg) + peripheral blood hematopoietic stem cells 1 day after completion of chemotherapylls 1 day after completion of chemotherapy)
- Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study + (The location of the fungating malignant wounds were: breast (n=24), neck (n=2), groin (n=2), spine (n=1); anus (n=1))
- Hajimohammadebrahim-Ketabforoush et al. (2019): Effect of Vitamin D Supplementation on Postcraniotomy Pain After Brain Tumor Surgery: A Randomized Clinical Trial + (The patients undergoing general anesthesia … The patients undergoing general anesthesia were induced with thiopental sodium 5e7 mg/kg, fentanyl 5 mg/kg, midazolam 0.02 mg/kg, lidocaine 1 mg/kg, atracurium 0.5 mg/kg, endotracheal intubation, and maintained with propofol 50e150 mg/kg/min in a 3 L/min oxygen/air mixture. Eventually, the patient’s awakening was induced with neostigmine and atropine to an extent of 0.07 mg/kg and 0.02 mg/kg, respectively.f 0.07 mg/kg and 0.02 mg/kg, respectively.)
- Cruciani et al. (2009): L-Carnitine Supplementation in Patients with Advanced Cancer and Carnitine Deficiency: A Double-Blind, Placebo-Controlled Study + (The protocol was amended during the course of the study, and patients receiving chemotherapy or radiation therapy were allowed under the modified protocol.)
- Sahebnasagh et al. (2017): Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial + (The radiation dose was 50-70Gy (1.8-2Gy 5x per day))
- Ehrenpreis et al. (2005): A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial of Retinol Palmitate (Vitamin A) for Symptomatic Chronic Radiation Proctopathy + (Time since radiation therapy ''mean (range)'': 4.35 years (0.67-19))
- Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer + (Treatment intent: Definitive = 86 Postoperative = 18 Induction chemotherapy: Yes = 96 No = 8)
- Dörr et al. (2007): Efficacy of Wobe-Mugos E for Reduction of Oral Mucositis after Radiotherapy + (Tumors were mainly located at tonsils (20. … Tumors were mainly located at tonsils (20.5%), floor of the mouth (15.7%), or tongue (margin:15.7%, base:12.0%, body:8.4%)</br></br>Patients received surgery prior to radiotherapy in n (%): </br></br>both arms together: 59 (85.5%)</br></br>enzyme-arm: 33 (91.7%)</br></br>placebo-arm: 26 (78.8%)</br></br>Radiotherapy protocols comprised conventional fractionation with 1.8–2.0 Gy/fraction, 5× per week to total doses of 60–66 Gy per 6–7 weeks, or hyperfractionation with 2 × 1.2 Gy per day, 5× per week to a total dose of 72 Gy per 6–7 weeks.ek to a total dose of 72 Gy per 6–7 weeks.)
- Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer + (Types of radiotherapy per arm: - intervention: 9x radiotherapy, 16x concurrent chemoradiotherapy - placebo: 6x radiotherapy, 14x concurrent chemoradiotherapy N for adjuvant/definitive setting per arm: - intervention: 15/10 - placebo:9/11)
- Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators + (Weekly docetaxel 36 mg/m<sup>2</sup> intravenously and dexamethasone (4 mg orally 12 hours before, 1 hour before, and 12 hours after docetaxel administration))
- Frankling et al. (2021): ‘Palliative-D’ - Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial + (With no intention to cure)
- Mondal et al. (2014): Comparative study among glutamine, acetyl-L-carnitine, vitamin-E and methylcobalamine for treatment of paclitaxel-induced peripheral neuropathy + (With paclitaxel as first or second line treatment)
- Cohen et al. (2018): Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial + (n = 11 (24%) patients received concurrent chemotherapy)
- Freedland et al. (2020): A Randomized Controlled Trial of a 6-month low carbohydrate intervention on disease progression in men with recurrent prostate cancer: Carbohydrate and Prostate Study 2 (CAPS2) + (n = 45 Surgery, n (%): 36 (80) Radiation, n (%): 9 (20))