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List of results

• Marucci et al. (2017): Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer  + (Treatment intent: Definitive = 86 Postoperative = 18 Induction chemotherapy: Yes = 96 No = 8)
• Dörr et al. (2007): Efficacy of Wobe-Mugos E for Reduction of Oral Mucositis after Radiotherapy  + (Tumors were mainly located at tonsils (20. … Tumors were mainly located at tonsils (20.5%), floor of the mouth (15.7%), or tongue (margin:15.7%, base:12.0%, body:8.4%)</br></br>Patients received surgery prior to radiotherapy in n (%): </br></br>both arms together: 59 (85.5%)</br></br>enzyme-arm: 33 (91.7%)</br></br>placebo-arm: 26 (78.8%)</br></br>Radiotherapy protocols comprised conventional fractionation with 1.8–2.0 Gy/fraction, 5× per week to total doses of 60–66 Gy per 6–7 weeks, or hyperfractionation with 2 × 1.2 Gy per day, 5× per week to a total dose of 72 Gy per 6–7 weeks.ek to a total dose of 72 Gy per 6–7 weeks.)
• Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer  + (Types of radiotherapy per arm: - intervention: 9x radiotherapy, 16x concurrent chemoradiotherapy - placebo: 6x radiotherapy, 14x concurrent chemoradiotherapy N for adjuvant/definitive setting per arm: - intervention: 15/10 - placebo:9/11)
• Beer et al. (2007): Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators  + (Weekly docetaxel 36 mg/m² intravenously and dexamethasone (4 mg orally 12 hours before, 1 hour before, and 12 hours after docetaxel administration))

• Frankling et al. (2021): ‘Palliative-D’ - Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial  + (With no intention to cure)

• Mondal et al. (2014): Comparative study among glutamine, acetyl-L-carnitine, vitamin-E and methylcobalamine for treatment of paclitaxel-induced peripheral neuropathy  + (With paclitaxel as first or second line treatment)
• Cohen et al. (2018): Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial  + (n = 11 (24%) patients received concurrent chemotherapy)
• Freedland et al. (2020): A Randomized Controlled Trial of a 6-month low carbohydrate intervention on disease progression in men with recurrent prostate cancer: Carbohydrate and Prostate Study 2 (CAPS2)  + (n = 45 Surgery, n (%): 36 (80) Radiation, n (%): 9 (20))