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List of results

• Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis  + (Daily fraction was 180 cGy to 200 cGy in f … Daily fraction was 180 cGy to 200 cGy in five weekly fractions,</br>total dose prescribed was 7,000 cGy;</br></br>No significant difference in the radiation dose, fraction, and duration was identified between intervention and placebo arm; all patients received concomitant chemotherapy with 5-fluorouracil and cis-platinumerapy with 5-fluorouracil and cis-platinum)
• Attia et al. (2008): Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer  + (Docetaxel was supplied commercially. Patients received, on a 28-day cycle, 35 mg/m² docetaxel i.v. on days 1, 8, and 15 over 1 hour)
• Ota et al. (2014): The effect of pyridoxine for prevention of hand-foot-syndrome in colorectal cancer patients with adjuvant chemotherapy using capecitabine: A randomized study  + (Eight 3-week cycles of 2,500 mg/m2 of capecitabine per day in two divided doses for 14 days, followed by a 7-day rest period)
• Jeon et al. (2016): Effect of intravenous high dose Vitamin C on postoperative pain and morphine use after laparoscopic colectomy: A randomized controlled trial  + (Elective laparoscopic colectomy)
• Hejazi et al. (2013): A pilot clinical trial of radioprotective effects of curcumin supplementation in patients with prostate cancer  + (External beam radiotherapy (EBRT), in combination with hormone ablation)
• Hejazi et al. (2016): Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study  + (External beam radiotherapy (EBRT), in combination with hormone ablation)
• Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation  + (External beam radiotherapy: LINAC or Cobal … External beam radiotherapy: LINAC or Cobalt-10, total mean radiation dose (SD): 62.3 (9.13), radiotherapy duration (wks) (SD): 7.38 (1.28);</br>daily fractions of 180– 200 cGy lasting from 5 to 9 weeks, for a total dose of 45-70 Gy, the radiation fields were the same for all patients, and the tongue was always includedtients, and the tongue was always included)
• Muecke et al. (2010): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology  + (External radiotherapy was delivered with a … External radiotherapy was delivered with a 6- to 18-MV linear accelerator. </br>Five fractions per week were planned. Treatment was given with a three- to four-field box technique. Radiotherapy was given as three-dimensional conformal radiotherapy. Computed tomography–based treatment planning was performed in all cases. The clinical target volume encompassed the primary tumor region and the pelvic regional lymph nodes. High-dose rate brachytherapy of the vagina was considered optional in accordance with German evidence-based guidelines. Brachytherapy was delivered by iridium 192 afterloading.was delivered by iridium 192 afterloading.)
• Muecke et al. (2013): Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology-a subgroup analysis of a multicenter, phase III trial  + (External radiotherapy was delivered with a … External radiotherapy was delivered with a 6- to 18-MV linear accelerator. Five fractions per week were planned. Treatment was given with a three- to four-field box technique. Radiotherapy was given as three-dimensional conformal radiotherapy. Computed tomography–based treatment planning was performed in all cases. The clinical target volume encompassed the primary tumor region and the pelvic regional lymph nodes. High-dose rate brachytherapy of the vagina was considered optional in accordance with German evidence-based guidelines. Brachytherapy was delivered by iridium 192 afterloading.was delivered by iridium 192 afterloading.)
• Özdelikara et al. (2017): The Effect of Reflexology on Chemotherapy-induced Nausea, Vomiting, and Fatigue in Breast Cancer Patients  + (First chemotherapy cycle between April 2011 and October 2013)
• Thamlikitkul et al. (2017): Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study  + (First cycle of AC chemotherapy)
• Jacot et al. (2016): Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study  + (Fluorouracil 500 mg/m<sup>2</sup& … Fluorouracil 500 mg/m² , epirubicin 100 mg/m² and cyclophosphamide 500 mg/m² (FEC) i.v. on day 1 every 21 days for three cycles, followed by docetaxel 100 mg/m2 i.v. on day 1 every 21 days for three cycles;</br>Docetaxel - 2 cyclophosphamide, methotrexate, 5-fluorouracile;</br>Trastuzumabes; Docetaxel - 2 cyclophosphamide, methotrexate, 5-fluorouracile; Trastuzumab)
• Bossi et al. (2017): A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high-dose cisplatin  + (HEC with cisplatin (single dose >50 mg/m2 every 21 or 28 day)
• Shooriabi et al. (2016): The effect of ginger extract on radiotherapy-oriented salivation in patients with xerostomia: A double-blind controlled study  + (Head and neck radiotherapy)
• Okabayashi et al. (2020): L-Carnitine Improves Postoperative Liver Function in Hepatectomized Patients  + (Hepatectomy (n=30 bisegmentectomy or extended hepatectomy, n=69 segmentectomy, and n=109 subsegmentectomy))
• Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer  + (In all patients: High (>90%) emetic risk * 5-Flouracil + epirubicin + cyclophosphamide (FEC): 45% (SD 75.0) * Docetaxel + doxorubicin and cyclophosphamide (TAC): 7% (SD 11.7) Low (10—30%) emetic risk * Docetaxel: 8% (SD 13.3))
• Salihah et al. (2016): The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting  + (In all patients: High (>90%) emetic risk * 5-Flouracil + epirubicin + cyclophosphamide (FEC): 45% (SD 75.0) * Docetaxel + doxorubicin and cyclophosphamide (TAC): 7% (SD 11.7) Low (10—30%) emetic risk * Docetaxel: 8% (SD 13.3))
• Montazeri et al. (2013): Effect of Herbal Therapy to Intensity Chemotherapy-Induced Nausea and Vomiting in Cancer Patients  + (In: ≥2 cycles of cisplatin chemotherapy Chemoregime: 50-100 mg cisplatin +/- others)
• Raei et al. (2013): Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients  + (In: ≥2 cycles of cisplatin chemotherapy Chemoregime: 50-100 mg Cisplatin +/- andere Antiemetika: Granisetron 3 mg + Dexamethazon 8mg)
• Scher et al. (2011): Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer  + (Intervention arm: 36 mg/m<sup>2</ … Intervention arm: 36 mg/m² docetaxel for 30-minute infusion on days 2, 9, and 16; and 8-mg oral dexamethasone about 12 hours, 3 hours, and 1 hour before docetaxel; nine doses of dexamethasone per 28-day, continued for up to 30 weeks or until unacceptable docetaxel toxicity or clinical disease progression</br>Control arm: 1-hour infusion of docetaxel at 75 mg/m² body-surface area on day 2; and 8-mg oral dexamethasone about 12 hours, 3 hours, and 1 hour before docetaxel infusion; three doses per 21-day cycle, continued for up to 30 weeks or until unacceptable docetaxel toxicity or clinical disease progressionil unacceptable docetaxel toxicity or clinical disease progression)
• Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study  + (Intervention arm: Dose of radiotherapy (cG … Intervention arm: Dose of radiotherapy (cGy): 6,824 (463.5), Placebo arm: Dose of radiotherapy (cGy): 6,651 (1,056.3);</br></br>Intervention arm: Duration of radiotherapy: 56 (8.7), Placebo arm: Duration of radiotherapy: 54 (11.8);</br></br>Intervention arm: concurrent chemotherapy: 20 (41), Placebo arm: concurrent chemotherapy: 20 (42)cebo arm: concurrent chemotherapy: 20 (42))
• Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study  + (Intervention arm: Dose of radiotherapy (cG … Intervention arm: Dose of radiotherapy (cGy): 6,824 (463.5),</br>Placebo arm: Dose of radiotherapy (cGy): 6,651 (1,056.3);</br></br>Intervention arm: Duration of radiotherapy: 56 (8.7),</br>Placebo arm: Duration of radiotherapy: 54 (11.8);</br></br>Intervention arm: concurrent chemotherapy: 20 (41)</br>Placebo arm: concurrent chemotherapy: 20 (42)cebo arm: concurrent chemotherapy: 20 (42))
• Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial  + (Irradiation of the entire brain or at least 60 % with a dose of 30-60 Gray fractionated over 5 x 1.8-3.0 Gray/week)
• Tsay et al. (2008): Effects of Reflexotherapy on Acute Postoperative Pain and Anxiety Among Patients With Digestive Cancer.  + (Major abdominal surgery for mainly hepatocellular cancer and gastric cancer in the 24 hours)
• Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture  + (Mean times from the last chemotherapy, last surgery, or last radiotherapy were comparable between groups (all 𝑃 values >0.25))
• Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial  + (Mean value (range) Radiation dose Aloe ar … Mean value (range) Radiation dose</br></br>Aloe arm: 65.54 (50-70) Gy</br></br>Placebo arm : 66.15 (54 - 70) Gy</br></br></br>Previous chemotherapy per arm: </br></br>Aloe arm: yes = 9 (69.2%); no = 4 (30.8%)</br></br>Placebo arm: yes = 12 (92.3%); no = 1 (7.7%)</br></br></br>Histology: </br></br>SCC: </br></br>Aloe arm = 11 (84.6%); Placebo arm = 12 (92.3%)</br></br>Mucoepidermoid carcinoma: </br></br>Aloe arm = 1 (7.7%); Placebo arm = 0</br> </br>Osteosarcoma: </br></br>Aloe arm = 1 (7.7%); Placebo arm = 1 (7.7%)loe arm = 1 (7.7%); Placebo arm = 1 (7.7%))
• Gorgu et al. (2013): The effect of zinc sulphate in the prevention of radiation induced oral mucositis in patents with head and neck cancer  + (Median radiation dose in all the patients was 6440 cGy (range: 4600‐7000 cGy); intervention arm: 6625 cGy (range: 6000‐7000 cGy) vs. control arm: 6316 cGy (range: 4600‐7000 cGy); n=20 with concurrent chemotherapy; n=24 with surgery before radiotherapy)
• Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer  + (Minimum of 6 months since completion of br … Minimum of 6 months since completion of breast surgery, adjuvant chemotherapy (including trastuzumab), and radiation therapy</br></br>Breast cancer treatments: n(%)</br>Chemotherapy: Poly E arm 29(97); Placebo arm 10(100)</br>Trastuzumab: Poly E arm 5(17); Placebo arm 2(20)</br>Radiation therapy: Poly E arm 23(77); Placebo arm 8(80)rapy: Poly E arm 23(77); Placebo arm 8(80))
• Grimison et al. (2020): Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial  + (Moderate-to-high emetogenic intravenous chemotherapy Chemotherapy regimen, n(%): Doxorubicin + cyclophosphamide = 20 (26) FOLFOX ± biological = 13 (17) Cisplatin based = 12 (15) FOLFIRINOX = 6 (8) Other = 27 (35))
• Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy  + (Moderately to highly emetogenic chemotherapy: 93% highly emetogenic, of which 68% anthracycline-based and 21% platinum-based)

• Bairati et al. (2005): A Randomized Trial of Antioxidant Vitamins to Prevent Second Primary Cancers in Head and Neck Cancer Patients  + (NA)
• Bairati et al. (2005): Randomized Trial of Antioxidant Vitamins to Prevent Acute Adverse Effects of Radiation Therapy in Head and Neck Cancer Patients  + (NA)
• Bairati et al. (2006): Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients  + (NA)
• Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer  + (NA)
• Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis  + (NA)
• Goossens et al. (2016): Phase III randomised chemoprevention study with selenium on the recurrence of non-invasive urothelial carcinoma. The SELEnium and BLAdder cancer Trial  + (NA)
• Karp et al. (2012): Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597  + (NA)
• Muecke et al. (2014): Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology: follow-up analysis of the survival data 6 years after cessation of randomization  + (NA)
• Paur et al. (2017): Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA  + (NA)
• Portenoy et al. (2012): Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial  + (NA)
• Stratton et al. (2010): Oral Selenium Supplementation Has No Effect on Prostate- Specific Antigen Velocity in Men Undergoing Active Surveillance for Localized Prostate Cancer  + (NA)

• Khodabakhshi et al. (2019): Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study  + (NI)
• Mayne et al. (2001): Randomized Trial of Supplemental beta-Carotene to Prevent Second Head and Neck Cancer  + (NI)
• Büntzel et al. (2010): Selenium Substitution During Radiotherapy of Solid Tumours - Laboratory Data from Two Observation Studies in Gynaecological and Head and Neck Cancer Patients  + (NI)
• Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain  + (NI)
• Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial  + (NI)
• Azizi et al. (2015): Efficacy of Topical and Systemic Vitamin E in Preventing Chemotherapy-induced Oral Mucositis  + (NI)
• Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS)  + (NI)
• Fallon et al. (2017) I: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies  + (NI)
• Fallon et al. (2017) II: Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies  + (NI)
• Mansourian et al. (2015): The effect of "curcuma Longa" topical gel on radiation -induced oral mucositis in patients with head and neck cancer  + (NI)
• Cruciani et al. (2012): L-Carnitine Supplementation for the Management of Fatigue in Patients With Cancer: An Eastern Cooperative Oncology Group Phase III, Randomized, Double-Blind, Placebo-Controlled Trial  + (NI)
• Da Costa et al. (2009): Effectiveness of Guarana (Paullinia cupana) for Postradiation Fatigue and Depression Results of a Pilot Double-Blind Randomized Study  + (NI)
• Tan et al. (2018): Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor  + (NI)
• Büntzel et al. (2010): Limited effects of selenium in the prevention of radiation-associated toxicities - results of a randomized study in head neck cancer patients  + (NI)
• Campos et al. (2011): Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy  + (NI)
• Yekta et al. (2012): Ginger as a miracle against chemotherapy-induced vomiting  + (NI)
• Sontakke et al. (2003): Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study  + (NI)
• Marx et al. (2017): The Effect of a Standardized Ginger Extract on Chemotherapy-Induced Nausea-Related Quality of Life in Patients Undergoing Moderately or Highly Emetogenic Chemotherapy: A Double Blind, Randomized, Placebo Controlled Trial  + (NI)
• Sanaati et al. (2016): Effect of Ginger and Chamomile on Nausea and Vomiting Caused by Chemotherapy in Iranian Women with Breast Cancer  + (NI)
• Dyer et al. (2013): Is reflexology as effective as aromatherapy massage for symptom relief in an adult outpatient oncology population?  + (NI)