Property:Specifications on cancer therapies
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Rastelli et al. (2011): Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial +
Anastrozole +
Ribeiro et al. (2017): Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer +
CAPOX (capecitabine + oxaliplatin) schedule; capecitabine; 5-fluorouracil and folinic acid +
Ripamonti et al. (1998): A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation +
External beam radiotherapy: LINAC or Cobalt-10, total mean radiation dose (SD): 62.3 (9.13), radiotherapy duration (wks) (SD): 7.38 (1.28);
daily fractions of 180– 200 cGy lasting from 5 to 9 weeks, for a total dose of 45-70 Gy, the radiation fields were the same for all patients, and the tongue was always included +
Rostock et al. (2013): Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture +
Mean times from the last chemotherapy, last surgery, or last radiotherapy were comparable between groups (all 𝑃 values >0.25) +
Ryan et al. (2011): Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients +
NI +
Ryan et al. (2013): Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients +
Standard fractionated RT (~1.8–2.4 Gy per session) for four to seven weeks with or without boost for a total radiation dose of ≥ 42 Gy
Prior (n(%)):
* Lumpectomy 27 (90%)
* Mastectomy 3 (10%)
* Chemotherapy before radiation 13 (43.3%) +
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Sahebjamee et al. (2015): Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial +
Mean value (range) Radiation dose
Aloe arm: 65.54 (50-70) Gy
Placebo arm : 66.15 (54 - 70) Gy
Previous chemotherapy per arm:
Aloe arm: yes = 9 (69.2%); no = 4 (30.8%)
Placebo arm: yes = 12 (92.3%); no = 1 (7.7%)
Histology:
SCC:
Aloe arm = 11 (84.6%); Placebo arm = 12 (92.3%)
Mucoepidermoid carcinoma:
Aloe arm = 1 (7.7%); Placebo arm = 0
Osteosarcoma:
Aloe arm = 1 (7.7%); Placebo arm = 1 (7.7%) +
Sahebnasagh et al. (2017): Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial +
The radiation dose was 50-70Gy (1.8-2Gy 5x per day) +
Salehi et al. (2015): Effect of Vitamin E on Oxaliplatin-induced Peripheral neuropathy Prevention: A Randomized Controlled Trial +
Oxiplatin-based chemotherapy (oxaliplatin + 5‑fluorouracil + leucovorin (FOLFOX4); oxaliplatin: 85 mg/m 2 intravenous (IV) on day 1, 5‑fluorouracil: 400 mg/m 2 IV bolus, followed by 600 mg/m 2 IV continuous infusion for 22 h on days 1 and 2, leucovorin: 200 mg/m 2 IV on days 1 and 2 as a 2‑h infusion before 5‑fluorouracil) +
Salihah et al. (2016): The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting +
In all patients:
High (>90%) emetic risk
* 5-Flouracil + epirubicin + cyclophosphamide (FEC): 45% (SD 75.0)
* Docetaxel + doxorubicin and cyclophosphamide (TAC): 7% (SD 11.7)
Low (10—30%) emetic risk
* Docetaxel: 8% (SD 13.3) +
Sanaati et al. (2016): Effect of Ginger and Chamomile on Nausea and Vomiting Caused by Chemotherapy in Iranian Women with Breast Cancer +
NI +
Sangthawan et al. (2013): A randomized double-blind, placebo-controlled trial of zinc sulfate supplementation for alleviation of radiation-induced oral mucositis and pharyngitis in head and neck cancer patients +
Radiation therapy alone or as postoperative radiation therapy,
all patients were treated with Cobalt-60 or 6 MV photon machine,
daily fractionation was 1.8 to 2 Gy, a total dose of 50 to 70 Gy over 5 to 7 weeks was administered +
Sangthawan et al. (2015): Effects of zinc sulfate supplementation on cell-mediated immune response in head and neck cancer patients treated with radiation therapy +
All patients treated with Cobalt 60 or 6 MV photon treatment machines, the daily fractionation was 2 Gy in 5 weekly fractions +
Scher et al. (2011): Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer +
Intervention arm: 36 mg/m<sup>2</sup> docetaxel for 30-minute infusion on days 2, 9, and 16; and 8-mg oral dexamethasone about 12 hours, 3 hours, and 1 hour before docetaxel; nine doses of dexamethasone per 28-day, continued for up to 30 weeks or until unacceptable docetaxel toxicity or clinical disease progression
Control arm: 1-hour infusion of docetaxel at 75 mg/m<sup>2</sup> body-surface area on day 2; and 8-mg oral dexamethasone about 12 hours, 3 hours, and 1 hour before docetaxel infusion; three doses per 21-day cycle, continued for up to 30 weeks or until unacceptable docetaxel toxicity or clinical disease progression +
Shamsaei et al. (2017): The Vitamin E Preventive Effect on Taxol-Induced Neuropathy Among Patients With Breast Cancer: A Randomized Clinical Trial +
Taxol-based chemotherapy +
Shapiro et al. (2016): Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) +
NI +
Sharp et al. (2009): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer +
? +
Sharp et al. (2010): A randomised, controlled trial of the psychological effects of reflexology in early breast cancer +
NI +
Shokri et al. (2017): Comparison of the Complications of Platinum-Based Adjuvant Chemotherapy With and Without Ginger in a Pilot Study on Ovarian Cancer Patients +
Patients who underwent cytoreductive surgery followed by platinum-based adjuvant chemotherapy +