Property:Specifications on cancer therapies
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B
Brown et al. (2019): Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial +
Continuous infusion of 2400 mg/m<sup>2</sup> of 5-fluorouracil (5-FU) over 46 to 48 hours, a bolus of 400 mg/m<sup>2</sup> of 5-FU, 400 mg/m<sup>2</sup> of leucovorin, and 85 mg/m<sup>2</sup> of oxaliplatin (mFOLFOX6) plus 5 mg/kg of bevacizumab administered intravenously every 14 days per institutional standard of care (1 cycle=14 days),
bevacizumab was allowed to be omitted during the first cycle and started with cycle 2 at the investigator’s discretion +
Büntzel et al. (2010): Limited effects of selenium in the prevention of radiation-associated toxicities - results of a randomized study in head neck cancer patients +
NI +
Büntzel et al. (2010): Selenium Substitution During Radiotherapy of Solid Tumours - Laboratory Data from Two Observation Studies in Gynaecological and Head and Neck Cancer Patients +
NI +
C
Campos et al. (2011): Guarana (Paullinia cupana) Improves Fatigue in Breast Cancer Patients Undergoing Systemic Chemotherapy +
NI +
Cavallini et al. (2005): Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy +
Post-Surgery: bilateral nerve-sparing radical retropubic prostatectomy +
Chan et al. (2011): Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer +
NA +
Chung et al. (2016): Randomized Trial of Vitamin C/E Complex for Prevention of Radiation- Induced Xerostomia in Patients with Head and Neck Cancer +
Types of radiotherapy per arm:
- intervention: 9x radiotherapy, 16x concurrent chemoradiotherapy
- placebo: 6x radiotherapy, 14x concurrent chemoradiotherapy
N for adjuvant/definitive setting per arm:
- intervention: 15/10
- placebo:9/11 +
Cohen et al. (2018): Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial +
n = 11 (24%) patients received concurrent chemotherapy +
Crew et al. (2012): Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer +
Minimum of 6 months since completion of breast surgery, adjuvant chemotherapy (including trastuzumab), and radiation therapy
Breast cancer treatments: n(%)
Chemotherapy: Poly E arm 29(97); Placebo arm 10(100)
Trastuzumab: Poly E arm 5(17); Placebo arm 2(20)
Radiation therapy: Poly E arm 23(77); Placebo arm 8(80) +
Cruciani et al. (2009): L-Carnitine Supplementation in Patients with Advanced Cancer and Carnitine Deficiency: A Double-Blind, Placebo-Controlled Study +
The protocol was amended during the course of the study, and patients receiving chemotherapy or radiation therapy were allowed under the modified protocol. +
Cruciani et al. (2012): L-Carnitine Supplementation for the Management of Fatigue in Patients With Cancer: An Eastern Cooperative Oncology Group Phase III, Randomized, Double-Blind, Placebo-Controlled Trial +
NI +
Côté et al. (2016): Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial +
Radiotherapy only:
intervention arm = 13; placebo arm = 10
Radiotherapy postoperative:
intervention arm = 7; placebo arm = 2
Radiochemotherapy:
intervention arm = 7; placebo arm = 15
Radiochemotherapy postoperative:
intervention arm = 1, placebo arm = 1 +
D
Da Costa et al. (2009): Effectiveness of Guarana (Paullinia cupana) for Postradiation Fatigue and Depression Results of a Pilot Double-Blind Randomized Study +
NI +
Dale et al. (2001): Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects +
All patients received 50-60 Gy of external beam radiation in 20-30 fractions over a period of 5 weeks, followed by intra-cavitary brachytherapy at a dose of 20–30 Gy using a BARC applicator. +
Dardano et al. (2012): The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with Iodine-131 +
<sup>131</sup>I treatment +
Del Giglio (2013): Purified Dry Extract of Paullinia cupana (Guarana) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study +
Systemic chemotherapy +
Delanian et al. (2003): Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis +
NA +
Dias et al. (2015): The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study +
Cisplatin +
Dos Santos Martins (2016): Placebo-Controlled, Double-Blind, Randomized Study of a Dry Guarana Extract in Patients with Head and Neck Tumors Undergoing Chemoradiotherapy: Effects on Fatigue and Quality of Life +
Radiotherapy consisted of 30 daily sessions lasting six weeks (total dose = 5,040 cGys in the supraclavicular fossa and lymphatic drainages and reaching 7,040 cGys in the tumor).
Platinum-based chemotherapy consisted of three cycles of cisplatin (100 mg/m2) every 21 days during the chemoradiotherapy. +