Property:Specifications on cancer therapies
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Kessels et al. (2017): Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma A Randomized Clinical Trial +
Study setting is prior to surgery. +
Khan et al. (2017): Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial +
NI +
Khodabakhshi et al. (2019): Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study +
NI +
Kirste et al. (2011): Boswellia serrata Acts on Cerebral Edema in Patients Irradiated for Brain Tumors. A Prospective, Randomized, Placebo-Controlled, Double-Blind Pilot Trial +
Irradiation of the entire brain or at least 60 % with a dose of 30-60 Gray fractionated over 5 x 1.8-3.0 Gray/week +
Konmun et al. (2017): A phase II randomized double-blind placebo-controlled study of 6-gingerol as an anti-emetic in solid tumor patients receiving moderately to highly emetogenic chemotherapy +
Moderately to highly emetogenic chemotherapy: 93% highly emetogenic, of which 68% anthracycline-based and 21% platinum-based +
Kottschade et al. (2011): The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase 3 clinical trial +
Taxan (58%), Cisplatin (4%), Carboplatin (1%), Oxaliplatin (26%), Combination (11%) +
Koyama et al. (2017): Intravenous Carnitine Administration in Addition to Parenteral Nutrition With Lipid Emulsion May Decrease the Inflammatory Reaction in Postoperative Surgical Patients +
Open or Laparoscopic surgery for gastric or colorectal cancer
+ Peripheral postoperative parenteral nutrition (PPN): glucose, amino acid, lipid emulsion +
Kraft et al. (2012): L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial +
At entry 88% of patients in the placebo and 92% of patients in the L-Carnitine group received chemotherapy. +
L
Laali et al. (2020): Effect of Selenium on Incidence and Severity of Mucositis during Radiotherapy in Patients with Head and Neck Cancer +
* Radiation therapy: 5 fractions per week at 60-70 Gy cumulative doses over 6 weeks to 7 weeks
* Chemotherapy: 18 (48.6%) patients from the selenium and 16 (47.1%) from the placebo arm with cisplatin (30-50mg/m2 weekly, during radiation)
* Grade of neutropenia and renal failure was evaluated based on the NCI CTCAE
* Creatinine level increase of > 0.3 mg/dL or 1.5–2.0 mg/dL above baselinewas considered as renal failure and a neutrophil count decrease to 1000–500 mm3 was considered as grade 3 of this toxicity
* After 7 weeks no differencences in the incidence of other adverse effects related to chemoradiation such as neutropenia and renal failure in the selenium arm and the placebo arm
+
Li et al. (2018): Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial +
Cisplatin-based chemotherapy (few patients with carboplatin or oxaliplatin) +
Lian et al. (2014): Comparing the Effectiveness of Green Tea versus Topical Metronidazole Powder in Malodorous Control of Fungating Malignant Wounds in a Controlled Randomised Study +
The location of the fungating malignant wounds were:
breast (n=24), neck (n=2), groin (n=2), spine (n=1); anus (n=1) +
Lichtmann et al. (2018): Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain +
NI +
Lin et al. (2006): Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study +
Intervention arm: Dose of radiotherapy (cGy): 6,824 (463.5),
Placebo arm: Dose of radiotherapy (cGy): 6,651 (1,056.3);
Intervention arm: Duration of radiotherapy: 56 (8.7),
Placebo arm: Duration of radiotherapy: 54 (11.8);
Intervention arm: concurrent chemotherapy: 20 (41)
Placebo arm: concurrent chemotherapy: 20 (42) +
Lin et al. (2008): Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study +
Intervention arm: Dose of radiotherapy (cGy): 6,824 (463.5), Placebo arm: Dose of radiotherapy (cGy): 6,651 (1,056.3);
Intervention arm: Duration of radiotherapy: 56 (8.7), Placebo arm: Duration of radiotherapy: 54 (11.8);
Intervention arm: concurrent chemotherapy: 20 (41), Placebo arm: concurrent chemotherapy: 20 (42) +
Lin et al. (2009): Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis +
Daily fraction was 180 cGy to 200 cGy in five weekly fractions,
total dose prescribed was 7,000 cGy;
No significant difference in the radiation dose, fraction, and duration was identified between intervention and placebo arm; all patients received concomitant chemotherapy with 5-fluorouracil and cis-platinum +
Lin et al. (2010): Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: subgroup analysis of a double-blind, randomized study +
Nasopharyngeal Cancer: daily fractionations of 180 cGy to 200 cGy in 5 weekly fractions; total dose: 7000 cGy
Oral Cancer: 7000 cGy was given to patients without surgery and 6000 cGy was prescribed as adjuvant treatment if they received an operation,
unilateral irradiation was performed for cancers arising from retromolar, unilateral gum, lip, or single focus of buccal mucosa; whereas bilateral irradiation was done for tumors arising from mouth floor or multiple foci of buccal mucosa +
Lissoni et al. (1998): Biotherapy with the Pineal Immunomodulating Hormone Melatonin versus Melatonin plus Aloe vera in Untreatable Advanced Solid Neoplasms +
Patients, for whom no other effective standard therapy was available, because of lack of response to previous chemotherapies or a poor clinical status precluding chemotherapy.
Previous chemotherapy
(patients were eligible after at least 1 month from the last chemotherapy course):
Aloe arm: 20/24
Control arm: 21/26 +
Lissoni et al. (2009): A Randomized Study of Chemotherapy versus Biochemotherapy with Chemotherapy plus Aloe arborescens in Patients with Metastatic Cancer +
Chemotherapy:
Non-small cell lung cancer: Chemotherapy consisted of cisplatin (CDDP) plus etoposide (VP16) or weekly vinorelbine (VNR)
Small cell lung cancer: Chemotherapy consisted of cisplatin (CDDP) plus etoposide (VP16)
Colorectal cancer: low-dose oxaliplatin (OXA) plus 5-fluorouracil (5-FU)
Gastric cancer: weekly 5-fluorouracil
Pancreatic adenocarcinoma: weekly gemcitabine (GEM) +
Liu et al. (2010): Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial +
Radioiodine therapy (131I) +
Lua et al. (2015): Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer +
In all patients:
High (>90%) emetic risk
* 5-Flouracil + epirubicin + cyclophosphamide (FEC): 45% (SD 75.0)
* Docetaxel + doxorubicin and cyclophosphamide (TAC): 7% (SD 11.7)
Low (10—30%) emetic risk
* Docetaxel: 8% (SD 13.3) +